Association of metabolic syndrome and its components with suicidal ideation and depression in adults: A nationally representative sample of the Korean population

Jeong Kyung Ko, Kyu Man Han, Cheolmin Shin, Seung Hoon Lee, Changsu Han, Yong Ku Kim, Ho-Kyoung Yoon, Young-Hoon Ko

Research output: Contribution to journalArticle

Abstract

Background: Few studies have evaluated the association of depressive symptoms and suicidal ideation with metabolic syndrome (MetS) and its components. This study examined the associations of MetS and its components with suicidal ideation and depression and determined the mediation effect of self-rated health (SRH) on these associations. Methods: This study was conducted using cross-sectional data on 9867 people (aged ≥ 19 years old) collected in 2014 and 2016 from a nationally representative sample of the Korean National Health and Nutrition Examination Survey. The associations of MetS with suicidal ideation and depression were estimated after adjusting for potential confounding factors using logistic regression analyses, and a mediation analysis by Hayes and Preacher was used to estimate the mediation pathway between such associations through SRH. Result: After adjusting for confounding factors, suicidal ideation was associated with MetS. Depressive symptoms and suicidal ideation were associated with two components of MetS: high triglyceride level and high fasting plasma glucose level. In the mediation analysis, we found a significant mediating effect of SRH on the association between high triglyceride level and suicidal ideation. Limitations: We cannot elucidate causal relationships because of the cross-sectional design. Conclusion: Our study provides the implication that a high triglyceride level and elevated fasting plasma glucose level may contribute suicidal risk and depressive symptoms in adults and that SRH may contribute to the development of suicidal ideation in adults via the apparent interaction with one of the components of MetS—high triglyceride level.

Original languageEnglish
Pages (from-to)319-326
Number of pages8
JournalJournal of Affective Disorders
Volume249
DOIs
Publication statusPublished - 2019 Apr 15

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Suicidal Ideation
Depression
Triglycerides
Population
Health
Fasting
Glucose
Nutrition Surveys
Logistic Models
Regression Analysis

Keywords

  • Depressive symptoms
  • Glucose
  • Metabolic syndrome
  • Patient Health Questionnaire-9
  • Suicidal ideation
  • Triglyceride

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

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title = "Association of metabolic syndrome and its components with suicidal ideation and depression in adults: A nationally representative sample of the Korean population",
abstract = "Background: Few studies have evaluated the association of depressive symptoms and suicidal ideation with metabolic syndrome (MetS) and its components. This study examined the associations of MetS and its components with suicidal ideation and depression and determined the mediation effect of self-rated health (SRH) on these associations. Methods: This study was conducted using cross-sectional data on 9867 people (aged ≥ 19 years old) collected in 2014 and 2016 from a nationally representative sample of the Korean National Health and Nutrition Examination Survey. The associations of MetS with suicidal ideation and depression were estimated after adjusting for potential confounding factors using logistic regression analyses, and a mediation analysis by Hayes and Preacher was used to estimate the mediation pathway between such associations through SRH. Result: After adjusting for confounding factors, suicidal ideation was associated with MetS. Depressive symptoms and suicidal ideation were associated with two components of MetS: high triglyceride level and high fasting plasma glucose level. In the mediation analysis, we found a significant mediating effect of SRH on the association between high triglyceride level and suicidal ideation. Limitations: We cannot elucidate causal relationships because of the cross-sectional design. Conclusion: Our study provides the implication that a high triglyceride level and elevated fasting plasma glucose level may contribute suicidal risk and depressive symptoms in adults and that SRH may contribute to the development of suicidal ideation in adults via the apparent interaction with one of the components of MetS—high triglyceride level.",
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author = "Ko, {Jeong Kyung} and Han, {Kyu Man} and Cheolmin Shin and Lee, {Seung Hoon} and Changsu Han and Kim, {Yong Ku} and Ho-Kyoung Yoon and Young-Hoon Ko",
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T1 - Association of metabolic syndrome and its components with suicidal ideation and depression in adults

T2 - A nationally representative sample of the Korean population

AU - Ko, Jeong Kyung

AU - Han, Kyu Man

AU - Shin, Cheolmin

AU - Lee, Seung Hoon

AU - Han, Changsu

AU - Kim, Yong Ku

AU - Yoon, Ho-Kyoung

AU - Ko, Young-Hoon

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Background: Few studies have evaluated the association of depressive symptoms and suicidal ideation with metabolic syndrome (MetS) and its components. This study examined the associations of MetS and its components with suicidal ideation and depression and determined the mediation effect of self-rated health (SRH) on these associations. Methods: This study was conducted using cross-sectional data on 9867 people (aged ≥ 19 years old) collected in 2014 and 2016 from a nationally representative sample of the Korean National Health and Nutrition Examination Survey. The associations of MetS with suicidal ideation and depression were estimated after adjusting for potential confounding factors using logistic regression analyses, and a mediation analysis by Hayes and Preacher was used to estimate the mediation pathway between such associations through SRH. Result: After adjusting for confounding factors, suicidal ideation was associated with MetS. Depressive symptoms and suicidal ideation were associated with two components of MetS: high triglyceride level and high fasting plasma glucose level. In the mediation analysis, we found a significant mediating effect of SRH on the association between high triglyceride level and suicidal ideation. Limitations: We cannot elucidate causal relationships because of the cross-sectional design. Conclusion: Our study provides the implication that a high triglyceride level and elevated fasting plasma glucose level may contribute suicidal risk and depressive symptoms in adults and that SRH may contribute to the development of suicidal ideation in adults via the apparent interaction with one of the components of MetS—high triglyceride level.

AB - Background: Few studies have evaluated the association of depressive symptoms and suicidal ideation with metabolic syndrome (MetS) and its components. This study examined the associations of MetS and its components with suicidal ideation and depression and determined the mediation effect of self-rated health (SRH) on these associations. Methods: This study was conducted using cross-sectional data on 9867 people (aged ≥ 19 years old) collected in 2014 and 2016 from a nationally representative sample of the Korean National Health and Nutrition Examination Survey. The associations of MetS with suicidal ideation and depression were estimated after adjusting for potential confounding factors using logistic regression analyses, and a mediation analysis by Hayes and Preacher was used to estimate the mediation pathway between such associations through SRH. Result: After adjusting for confounding factors, suicidal ideation was associated with MetS. Depressive symptoms and suicidal ideation were associated with two components of MetS: high triglyceride level and high fasting plasma glucose level. In the mediation analysis, we found a significant mediating effect of SRH on the association between high triglyceride level and suicidal ideation. Limitations: We cannot elucidate causal relationships because of the cross-sectional design. Conclusion: Our study provides the implication that a high triglyceride level and elevated fasting plasma glucose level may contribute suicidal risk and depressive symptoms in adults and that SRH may contribute to the development of suicidal ideation in adults via the apparent interaction with one of the components of MetS—high triglyceride level.

KW - Depressive symptoms

KW - Glucose

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KW - Suicidal ideation

KW - Triglyceride

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