Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis

Hye-Jin Yoo, Soon Young Hwang, Ho Cheol Hong, Hae Yoon Choi, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Dong Seop Choi, Sei-Hyun Baik, Kyung Mook Choi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: Despite recent interest in differential impact of body size phenotypes on cardiovascular outcomes and mortality, studies evaluating the association between body size phenotypes and indicators of atherosclerosis are limited. This study investigated the relationship of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis in Korean adults without cardiovascular disease. Methods: A total of 1012 participants (575 men and 437 women, mean age 50.8 years), who underwent a health examination between April 2012 and May 2013 were prospectively enrolled based on inclusion and exclusion criteria. Study subjects were classified according to body mass index (BMI) and the presence/absence of metabolic syndrome. Results: The prevalence of metabolically healthy normal weight (MHNW), MANW, MHO, and metabolically abnormal obese (MAO) were 54.84%, 6.42%, 22.83%, and 15.91%, respectively. Individuals with MANW had significantly higher brachial-ankle pulse wave velocity and maximal carotid intima-media thickness values than those with MHO, after adjusting for age and gender (P=0.026 and P=0.018, respectively). The odds ratio (OR) of arterial stiffness and carotid atherosclerosis in the MANW group were significantly higher than in the MHNW group in unadjusted models. Furthermore, multivariable models showed that increased OR of carotid atherosclerosis in the MANW group persisted even after adjusting for confounding factors (OR=2.98, 95% CI=[1.54, 5.73], P=0.011). Conclusions: Compared to MHNW or MHO subjects, Korean men and women with the MANW phenotype exhibited increased arterial stiffness and carotid atherosclerosis.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalAtherosclerosis
Volume234
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Vascular Stiffness
Carotid Artery Diseases
Weights and Measures
Odds Ratio
Body Size
Phenotype
Carotid Intima-Media Thickness
Pulse Wave Analysis
Ankle
Atherosclerosis
Healthy Volunteers
Body Mass Index
Arm
Cardiovascular Diseases
Outcome Assessment (Health Care)
Mortality

Keywords

  • Atherosclerosis
  • Metabolically abnormal but normal weight
  • Metabolically healthy but obese

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

@article{472c3b31344f4ceb92d184bc26000380,
title = "Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis",
abstract = "Objective: Despite recent interest in differential impact of body size phenotypes on cardiovascular outcomes and mortality, studies evaluating the association between body size phenotypes and indicators of atherosclerosis are limited. This study investigated the relationship of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis in Korean adults without cardiovascular disease. Methods: A total of 1012 participants (575 men and 437 women, mean age 50.8 years), who underwent a health examination between April 2012 and May 2013 were prospectively enrolled based on inclusion and exclusion criteria. Study subjects were classified according to body mass index (BMI) and the presence/absence of metabolic syndrome. Results: The prevalence of metabolically healthy normal weight (MHNW), MANW, MHO, and metabolically abnormal obese (MAO) were 54.84{\%}, 6.42{\%}, 22.83{\%}, and 15.91{\%}, respectively. Individuals with MANW had significantly higher brachial-ankle pulse wave velocity and maximal carotid intima-media thickness values than those with MHO, after adjusting for age and gender (P=0.026 and P=0.018, respectively). The odds ratio (OR) of arterial stiffness and carotid atherosclerosis in the MANW group were significantly higher than in the MHNW group in unadjusted models. Furthermore, multivariable models showed that increased OR of carotid atherosclerosis in the MANW group persisted even after adjusting for confounding factors (OR=2.98, 95{\%} CI=[1.54, 5.73], P=0.011). Conclusions: Compared to MHNW or MHO subjects, Korean men and women with the MANW phenotype exhibited increased arterial stiffness and carotid atherosclerosis.",
keywords = "Atherosclerosis, Metabolically abnormal but normal weight, Metabolically healthy but obese",
author = "Hye-Jin Yoo and Hwang, {Soon Young} and Hong, {Ho Cheol} and Choi, {Hae Yoon} and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Choi, {Dong Seop} and Sei-Hyun Baik and Choi, {Kyung Mook}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.atherosclerosis.2014.02.033",
language = "English",
volume = "234",
pages = "218--223",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis

AU - Yoo, Hye-Jin

AU - Hwang, Soon Young

AU - Hong, Ho Cheol

AU - Choi, Hae Yoon

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Choi, Dong Seop

AU - Baik, Sei-Hyun

AU - Choi, Kyung Mook

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: Despite recent interest in differential impact of body size phenotypes on cardiovascular outcomes and mortality, studies evaluating the association between body size phenotypes and indicators of atherosclerosis are limited. This study investigated the relationship of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis in Korean adults without cardiovascular disease. Methods: A total of 1012 participants (575 men and 437 women, mean age 50.8 years), who underwent a health examination between April 2012 and May 2013 were prospectively enrolled based on inclusion and exclusion criteria. Study subjects were classified according to body mass index (BMI) and the presence/absence of metabolic syndrome. Results: The prevalence of metabolically healthy normal weight (MHNW), MANW, MHO, and metabolically abnormal obese (MAO) were 54.84%, 6.42%, 22.83%, and 15.91%, respectively. Individuals with MANW had significantly higher brachial-ankle pulse wave velocity and maximal carotid intima-media thickness values than those with MHO, after adjusting for age and gender (P=0.026 and P=0.018, respectively). The odds ratio (OR) of arterial stiffness and carotid atherosclerosis in the MANW group were significantly higher than in the MHNW group in unadjusted models. Furthermore, multivariable models showed that increased OR of carotid atherosclerosis in the MANW group persisted even after adjusting for confounding factors (OR=2.98, 95% CI=[1.54, 5.73], P=0.011). Conclusions: Compared to MHNW or MHO subjects, Korean men and women with the MANW phenotype exhibited increased arterial stiffness and carotid atherosclerosis.

AB - Objective: Despite recent interest in differential impact of body size phenotypes on cardiovascular outcomes and mortality, studies evaluating the association between body size phenotypes and indicators of atherosclerosis are limited. This study investigated the relationship of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis in Korean adults without cardiovascular disease. Methods: A total of 1012 participants (575 men and 437 women, mean age 50.8 years), who underwent a health examination between April 2012 and May 2013 were prospectively enrolled based on inclusion and exclusion criteria. Study subjects were classified according to body mass index (BMI) and the presence/absence of metabolic syndrome. Results: The prevalence of metabolically healthy normal weight (MHNW), MANW, MHO, and metabolically abnormal obese (MAO) were 54.84%, 6.42%, 22.83%, and 15.91%, respectively. Individuals with MANW had significantly higher brachial-ankle pulse wave velocity and maximal carotid intima-media thickness values than those with MHO, after adjusting for age and gender (P=0.026 and P=0.018, respectively). The odds ratio (OR) of arterial stiffness and carotid atherosclerosis in the MANW group were significantly higher than in the MHNW group in unadjusted models. Furthermore, multivariable models showed that increased OR of carotid atherosclerosis in the MANW group persisted even after adjusting for confounding factors (OR=2.98, 95% CI=[1.54, 5.73], P=0.011). Conclusions: Compared to MHNW or MHO subjects, Korean men and women with the MANW phenotype exhibited increased arterial stiffness and carotid atherosclerosis.

KW - Atherosclerosis

KW - Metabolically abnormal but normal weight

KW - Metabolically healthy but obese

UR - http://www.scopus.com/inward/record.url?scp=84897936104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897936104&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2014.02.033

DO - 10.1016/j.atherosclerosis.2014.02.033

M3 - Article

VL - 234

SP - 218

EP - 223

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -