Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression

Yeon Mok Oh, Byeong Ho Jeong, Sook Young Woo, Su Young Kim, Hojoong Kim, Ji Hyun Lee, Seong Yong Lim, Chin Kook Rhee, Kwang Ha Yoo, Jin Hwa Lee, Hyoung Kyu Yoon, Don D. Sin, Sang Do Lee, Eun Kyung Kim, Hye Yun Park, Tae Hyung Kim, Tae Rim Shin, Sang Yeub Lee, Ho Il Yoon, Seung Soo Sheen & 26 others Joo Hun Park, Yong Bum Park, Changhwan Kim, Yong Il Hwang, Young Sam Kim, Ji Ye Jung, Yoon Ki Hong, Seung Won Ra, Joon Beom Seo, Sang Min Lee, In A. Jeong, Chang Hoon Lee, Sei Won Lee, Jae Seung Lee, Jin Won Huh, Ji Yong Moon, Hye Kyeong Park, Jin Woo Kim, Woo Jin Kim, Kang Hyeon Choi, Joo Ock Na, Doh Hyung Kim, Hye Sook Choi, Kwang Ha Lee, Myung Jae Park, Sung Soon Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Rationale: Two adipokines, leptin and adiponectin, regulate metabolic and inflammatory systems reciprocally. The role of adiponectin in chronic obstructive pulmonary disease (COPD) has been studied. However, there are few data evaluating the relationship of plasma leptin with COPD severity or progression. Objectives: The objective of this study was to evaluate the relationship of leptin, adiponectin, and the leptin/adiponectin ratio with COPD severity and progression according to COPD phenotypes. Methods: Plasma leptin and adiponectin levels were measured in 196 subjects with COPD selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and adiponectin levels and the leptin/adiponectin ratio to COPD severity and progression over 3 years. Measurements and Main Results: The concentration of adiponectin in plasma positively correlated with percent emphysema on initial computed tomography (CT) (adjusted P = 0.022), whereas plasma leptin concentrations and the leptin/adiponectin ratio exhibited a significant inverse correlation with initial FEV1 (adjusted P = 0.013 for leptin and adjusted P = 0.041 for leptin/adiponectin ratio). Increased plasma leptin and leptin/adiponectin ratiowere significantly associated with change in percent emphysema over 3 years (adjusted P = 0.037 for leptin and adjusted P = 0.029 for leptin/adiponectin ratio), whereas none of the adipokines demonstrated an association with FEV1 decline over the 3-year period. Conclusions: Plasma adiponectin and leptin vary according to COPD phenotypes. Plasma leptin and the leptin/adiponectin ratio, but not adiponectin, were significantly associated with changes in CT-assessed emphysema, suggesting a potential role as a biomarker in emphysema progression in patients with COPD.

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalAnnals of the American Thoracic Society
Volume12
Issue number7
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

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Adipokines
Leptin
Adiponectin
Chronic Obstructive Pulmonary Disease
Disease Progression
Emphysema
Linear Models
Tomography
Phenotype
Obstructive Lung Diseases

Keywords

  • Adiponectin
  • Chronic obstructive pulmonary disease
  • Emphysema
  • Leptin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression. / Oh, Yeon Mok; Jeong, Byeong Ho; Woo, Sook Young; Kim, Su Young; Kim, Hojoong; Lee, Ji Hyun; Lim, Seong Yong; Rhee, Chin Kook; Yoo, Kwang Ha; Lee, Jin Hwa; Yoon, Hyoung Kyu; Sin, Don D.; Lee, Sang Do; Kim, Eun Kyung; Park, Hye Yun; Kim, Tae Hyung; Shin, Tae Rim; Lee, Sang Yeub; Yoon, Ho Il; Sheen, Seung Soo; Park, Joo Hun; Park, Yong Bum; Kim, Changhwan; Hwang, Yong Il; Kim, Young Sam; Jung, Ji Ye; Hong, Yoon Ki; Ra, Seung Won; Seo, Joon Beom; Lee, Sang Min; Jeong, In A.; Lee, Chang Hoon; Lee, Sei Won; Lee, Jae Seung; Huh, Jin Won; Moon, Ji Yong; Park, Hye Kyeong; Kim, Jin Woo; Kim, Woo Jin; Choi, Kang Hyeon; Na, Joo Ock; Kim, Doh Hyung; Choi, Hye Sook; Lee, Kwang Ha; Park, Myung Jae; Lee, Sung Soon.

In: Annals of the American Thoracic Society, Vol. 12, No. 7, 01.01.2015, p. 1005-1012.

Research output: Contribution to journalArticle

Oh, YM, Jeong, BH, Woo, SY, Kim, SY, Kim, H, Lee, JH, Lim, SY, Rhee, CK, Yoo, KH, Lee, JH, Yoon, HK, Sin, DD, Lee, SD, Kim, EK, Park, HY, Kim, TH, Shin, TR, Lee, SY, Yoon, HI, Sheen, SS, Park, JH, Park, YB, Kim, C, Hwang, YI, Kim, YS, Jung, JY, Hong, YK, Ra, SW, Seo, JB, Lee, SM, Jeong, IA, Lee, CH, Lee, SW, Lee, JS, Huh, JW, Moon, JY, Park, HK, Kim, JW, Kim, WJ, Choi, KH, Na, JO, Kim, DH, Choi, HS, Lee, KH, Park, MJ & Lee, SS 2015, 'Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression', Annals of the American Thoracic Society, vol. 12, no. 7, pp. 1005-1012. https://doi.org/10.1513/AnnalsATS.201501-005OC
Oh, Yeon Mok ; Jeong, Byeong Ho ; Woo, Sook Young ; Kim, Su Young ; Kim, Hojoong ; Lee, Ji Hyun ; Lim, Seong Yong ; Rhee, Chin Kook ; Yoo, Kwang Ha ; Lee, Jin Hwa ; Yoon, Hyoung Kyu ; Sin, Don D. ; Lee, Sang Do ; Kim, Eun Kyung ; Park, Hye Yun ; Kim, Tae Hyung ; Shin, Tae Rim ; Lee, Sang Yeub ; Yoon, Ho Il ; Sheen, Seung Soo ; Park, Joo Hun ; Park, Yong Bum ; Kim, Changhwan ; Hwang, Yong Il ; Kim, Young Sam ; Jung, Ji Ye ; Hong, Yoon Ki ; Ra, Seung Won ; Seo, Joon Beom ; Lee, Sang Min ; Jeong, In A. ; Lee, Chang Hoon ; Lee, Sei Won ; Lee, Jae Seung ; Huh, Jin Won ; Moon, Ji Yong ; Park, Hye Kyeong ; Kim, Jin Woo ; Kim, Woo Jin ; Choi, Kang Hyeon ; Na, Joo Ock ; Kim, Doh Hyung ; Choi, Hye Sook ; Lee, Kwang Ha ; Park, Myung Jae ; Lee, Sung Soon. / Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression. In: Annals of the American Thoracic Society. 2015 ; Vol. 12, No. 7. pp. 1005-1012.
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abstract = "Rationale: Two adipokines, leptin and adiponectin, regulate metabolic and inflammatory systems reciprocally. The role of adiponectin in chronic obstructive pulmonary disease (COPD) has been studied. However, there are few data evaluating the relationship of plasma leptin with COPD severity or progression. Objectives: The objective of this study was to evaluate the relationship of leptin, adiponectin, and the leptin/adiponectin ratio with COPD severity and progression according to COPD phenotypes. Methods: Plasma leptin and adiponectin levels were measured in 196 subjects with COPD selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and adiponectin levels and the leptin/adiponectin ratio to COPD severity and progression over 3 years. Measurements and Main Results: The concentration of adiponectin in plasma positively correlated with percent emphysema on initial computed tomography (CT) (adjusted P = 0.022), whereas plasma leptin concentrations and the leptin/adiponectin ratio exhibited a significant inverse correlation with initial FEV1 (adjusted P = 0.013 for leptin and adjusted P = 0.041 for leptin/adiponectin ratio). Increased plasma leptin and leptin/adiponectin ratiowere significantly associated with change in percent emphysema over 3 years (adjusted P = 0.037 for leptin and adjusted P = 0.029 for leptin/adiponectin ratio), whereas none of the adipokines demonstrated an association with FEV1 decline over the 3-year period. Conclusions: Plasma adiponectin and leptin vary according to COPD phenotypes. Plasma leptin and the leptin/adiponectin ratio, but not adiponectin, were significantly associated with changes in CT-assessed emphysema, suggesting a potential role as a biomarker in emphysema progression in patients with COPD.",
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author = "Oh, {Yeon Mok} and Jeong, {Byeong Ho} and Woo, {Sook Young} and Kim, {Su Young} and Hojoong Kim and Lee, {Ji Hyun} and Lim, {Seong Yong} and Rhee, {Chin Kook} and Yoo, {Kwang Ha} and Lee, {Jin Hwa} and Yoon, {Hyoung Kyu} and Sin, {Don D.} and Lee, {Sang Do} and Kim, {Eun Kyung} and Park, {Hye Yun} and Kim, {Tae Hyung} and Shin, {Tae Rim} and Lee, {Sang Yeub} and Yoon, {Ho Il} and Sheen, {Seung Soo} and Park, {Joo Hun} and Park, {Yong Bum} and Changhwan Kim and Hwang, {Yong Il} and Kim, {Young Sam} and Jung, {Ji Ye} and Hong, {Yoon Ki} and Ra, {Seung Won} and Seo, {Joon Beom} and Lee, {Sang Min} and Jeong, {In A.} and Lee, {Chang Hoon} and Lee, {Sei Won} and Lee, {Jae Seung} and Huh, {Jin Won} and Moon, {Ji Yong} and Park, {Hye Kyeong} and Kim, {Jin Woo} and Kim, {Woo Jin} and Choi, {Kang Hyeon} and Na, {Joo Ock} and Kim, {Doh Hyung} and Choi, {Hye Sook} and Lee, {Kwang Ha} and Park, {Myung Jae} and Lee, {Sung Soon}",
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T1 - Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression

AU - Oh, Yeon Mok

AU - Jeong, Byeong Ho

AU - Woo, Sook Young

AU - Kim, Su Young

AU - Kim, Hojoong

AU - Lee, Ji Hyun

AU - Lim, Seong Yong

AU - Rhee, Chin Kook

AU - Yoo, Kwang Ha

AU - Lee, Jin Hwa

AU - Yoon, Hyoung Kyu

AU - Sin, Don D.

AU - Lee, Sang Do

AU - Kim, Eun Kyung

AU - Park, Hye Yun

AU - Kim, Tae Hyung

AU - Shin, Tae Rim

AU - Lee, Sang Yeub

AU - Yoon, Ho Il

AU - Sheen, Seung Soo

AU - Park, Joo Hun

AU - Park, Yong Bum

AU - Kim, Changhwan

AU - Hwang, Yong Il

AU - Kim, Young Sam

AU - Jung, Ji Ye

AU - Hong, Yoon Ki

AU - Ra, Seung Won

AU - Seo, Joon Beom

AU - Lee, Sang Min

AU - Jeong, In A.

AU - Lee, Chang Hoon

AU - Lee, Sei Won

AU - Lee, Jae Seung

AU - Huh, Jin Won

AU - Moon, Ji Yong

AU - Park, Hye Kyeong

AU - Kim, Jin Woo

AU - Kim, Woo Jin

AU - Choi, Kang Hyeon

AU - Na, Joo Ock

AU - Kim, Doh Hyung

AU - Choi, Hye Sook

AU - Lee, Kwang Ha

AU - Park, Myung Jae

AU - Lee, Sung Soon

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Rationale: Two adipokines, leptin and adiponectin, regulate metabolic and inflammatory systems reciprocally. The role of adiponectin in chronic obstructive pulmonary disease (COPD) has been studied. However, there are few data evaluating the relationship of plasma leptin with COPD severity or progression. Objectives: The objective of this study was to evaluate the relationship of leptin, adiponectin, and the leptin/adiponectin ratio with COPD severity and progression according to COPD phenotypes. Methods: Plasma leptin and adiponectin levels were measured in 196 subjects with COPD selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and adiponectin levels and the leptin/adiponectin ratio to COPD severity and progression over 3 years. Measurements and Main Results: The concentration of adiponectin in plasma positively correlated with percent emphysema on initial computed tomography (CT) (adjusted P = 0.022), whereas plasma leptin concentrations and the leptin/adiponectin ratio exhibited a significant inverse correlation with initial FEV1 (adjusted P = 0.013 for leptin and adjusted P = 0.041 for leptin/adiponectin ratio). Increased plasma leptin and leptin/adiponectin ratiowere significantly associated with change in percent emphysema over 3 years (adjusted P = 0.037 for leptin and adjusted P = 0.029 for leptin/adiponectin ratio), whereas none of the adipokines demonstrated an association with FEV1 decline over the 3-year period. Conclusions: Plasma adiponectin and leptin vary according to COPD phenotypes. Plasma leptin and the leptin/adiponectin ratio, but not adiponectin, were significantly associated with changes in CT-assessed emphysema, suggesting a potential role as a biomarker in emphysema progression in patients with COPD.

AB - Rationale: Two adipokines, leptin and adiponectin, regulate metabolic and inflammatory systems reciprocally. The role of adiponectin in chronic obstructive pulmonary disease (COPD) has been studied. However, there are few data evaluating the relationship of plasma leptin with COPD severity or progression. Objectives: The objective of this study was to evaluate the relationship of leptin, adiponectin, and the leptin/adiponectin ratio with COPD severity and progression according to COPD phenotypes. Methods: Plasma leptin and adiponectin levels were measured in 196 subjects with COPD selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and adiponectin levels and the leptin/adiponectin ratio to COPD severity and progression over 3 years. Measurements and Main Results: The concentration of adiponectin in plasma positively correlated with percent emphysema on initial computed tomography (CT) (adjusted P = 0.022), whereas plasma leptin concentrations and the leptin/adiponectin ratio exhibited a significant inverse correlation with initial FEV1 (adjusted P = 0.013 for leptin and adjusted P = 0.041 for leptin/adiponectin ratio). Increased plasma leptin and leptin/adiponectin ratiowere significantly associated with change in percent emphysema over 3 years (adjusted P = 0.037 for leptin and adjusted P = 0.029 for leptin/adiponectin ratio), whereas none of the adipokines demonstrated an association with FEV1 decline over the 3-year period. Conclusions: Plasma adiponectin and leptin vary according to COPD phenotypes. Plasma leptin and the leptin/adiponectin ratio, but not adiponectin, were significantly associated with changes in CT-assessed emphysema, suggesting a potential role as a biomarker in emphysema progression in patients with COPD.

KW - Adiponectin

KW - Chronic obstructive pulmonary disease

KW - Emphysema

KW - Leptin

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JF - Annals of the American Thoracic Society

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