TY - JOUR
T1 - Association of pooled cohort risk scores with vascular inflammation and coronary artery calcification in Korean adults
AU - Yoo, Hye Jin
AU - Yong, Hwan-Seok
AU - Hwang, Soon Young
AU - Eo, Jae Seon
AU - Hong, Ho Cheol
AU - Seo, Ji A
AU - Kim, Sin Gon
AU - Kim, Nan Hee
AU - Choi, Dong Seop
AU - Baik, Sei-Hyun
AU - Choi, Kyung Mook
N1 - Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( 2015R1A1A1A05001173 , H.J.Y.) and by the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( HI14C0133 , K.M.C.).
Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objectives A new pooled cohort risk equation to estimate atherosclerotic cardiovascular disease (CVD) risk was recently published, but the equation is based primarily on data from Caucasian populations. The relationship of this new risk scoring system with vascular inflammation and calcification has yet to be examined. Methods A total of 74 participants were retrospectively selected based on inclusion and exclusion criteria. All participants underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and multi-detector computed tomography (MDCT) examination in the Korea University Guro Hospital between June 2009 and May 2013. Vascular inflammation of the carotid artery was measured as target-to-background ratio (TBR) using 18F-FDG-PET/CT and coronary artery calcification was quantified as Agatston score by MDCT. Results Agatston scores were not significantly associated with any metabolic risk factors, but maximum TBR values exhibited a significant positive correlation with body mass index (r = 0.31, P = 0.01), waist circumference (r = 0.42, P < 0.01), waist-to-hip ratio (r = 0.49, P < 0.01), and systolic (r = 0.35, P < 0.01) and diastolic blood pressure (r = 0.39, P < 0.01). Furthermore, maximum TBR values were significantly correlated with serum high-sensitivity C-reactive protein (hsCRP) levels (r = 0.26, P = 0.03), whereas Agatston scores had no correlation. When pooled cohort risk equation scores were divided into incremental tertiles, age, waist circumference, waist-to-hip ratio and systolic blood pressure showed significant incremental trends. In particular, pooled cohort risk scores exhibited a significant positive correlation with maximum TBR values (r = 0.35, P < 0.01), but not with Agatston scores (r = 0.11, P = 0.34). Conclusions The pooled cohort risk equation exhibited significant positive correlations with vascular inflammation but not with calcification in Asian subjects without CVD, suggesting that this novel risk equation may detect early inflammatory changes preceding the structural modification of vessel walls.
AB - Objectives A new pooled cohort risk equation to estimate atherosclerotic cardiovascular disease (CVD) risk was recently published, but the equation is based primarily on data from Caucasian populations. The relationship of this new risk scoring system with vascular inflammation and calcification has yet to be examined. Methods A total of 74 participants were retrospectively selected based on inclusion and exclusion criteria. All participants underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and multi-detector computed tomography (MDCT) examination in the Korea University Guro Hospital between June 2009 and May 2013. Vascular inflammation of the carotid artery was measured as target-to-background ratio (TBR) using 18F-FDG-PET/CT and coronary artery calcification was quantified as Agatston score by MDCT. Results Agatston scores were not significantly associated with any metabolic risk factors, but maximum TBR values exhibited a significant positive correlation with body mass index (r = 0.31, P = 0.01), waist circumference (r = 0.42, P < 0.01), waist-to-hip ratio (r = 0.49, P < 0.01), and systolic (r = 0.35, P < 0.01) and diastolic blood pressure (r = 0.39, P < 0.01). Furthermore, maximum TBR values were significantly correlated with serum high-sensitivity C-reactive protein (hsCRP) levels (r = 0.26, P = 0.03), whereas Agatston scores had no correlation. When pooled cohort risk equation scores were divided into incremental tertiles, age, waist circumference, waist-to-hip ratio and systolic blood pressure showed significant incremental trends. In particular, pooled cohort risk scores exhibited a significant positive correlation with maximum TBR values (r = 0.35, P < 0.01), but not with Agatston scores (r = 0.11, P = 0.34). Conclusions The pooled cohort risk equation exhibited significant positive correlations with vascular inflammation but not with calcification in Asian subjects without CVD, suggesting that this novel risk equation may detect early inflammatory changes preceding the structural modification of vessel walls.
KW - Coronary artery calcification
KW - Pooled cohort risk scores
KW - Vascular inflammation
UR - http://www.scopus.com/inward/record.url?scp=84958185578&partnerID=8YFLogxK
U2 - 10.1016/j.metabol.2015.10.016
DO - 10.1016/j.metabol.2015.10.016
M3 - Article
C2 - 26892510
AN - SCOPUS:84958185578
SN - 0026-0495
VL - 65
SP - 1
EP - 7
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 3
ER -
