Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men

Kenneth R. Motoyama, J. David Curb, Takashi Kadowaki, Aiman El-Saed, Robert D. Abbott, Tomonori Okamura, Rhobert W. Evans, Yasuyuki Nakamura, Kim Sutton-Tyrrell, Beatriz L. Rodriquez, Aya Kadota, Daniel Edmundowicz, Bradley J. Willcox, Jina Choo, Nakata Katsumi, Teruo Otake, Sayaka Kadowaki, Lewis H. Kuller, Hirotusgu Ueshima, Akira Sekikawa

Research output: Contribution to journalArticle

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Abstract

Background: The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known. Objective: Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40-49 y. Design: We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used. Results: Serum n = 6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [β = -0.39 (P < 0.001), -0.38 (P < 0.001), and -0.33 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [β = -0.15 (P < 0.001), -0.22 (P < 0.001), and -0.13 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (β = 4.49, P < 0.001) and Japanese (β = 3.73, P < 0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (β = 2.15, P < 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (β = 2.68, P < 0.01). Conclusion: Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume90
Issue number1
DOIs
Publication statusPublished - 2009 Jul 1

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Omega-3 Fatty Acids
Unsaturated Fatty Acids
HDL Cholesterol
Asian Americans
Lipids
Triglycerides
Serum
Population
Eicosapentaenoic Acid
Gas Chromatography
Body Mass Index
Ethanol
Fatty Acids
Cross-Sectional Studies
Smoking

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Motoyama, K. R., Curb, J. D., Kadowaki, T., El-Saed, A., Abbott, R. D., Okamura, T., ... Sekikawa, A. (2009). Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men. American Journal of Clinical Nutrition, 90(1), 49-55. https://doi.org/10.3945/ajcn.2008.26761

Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men. / Motoyama, Kenneth R.; Curb, J. David; Kadowaki, Takashi; El-Saed, Aiman; Abbott, Robert D.; Okamura, Tomonori; Evans, Rhobert W.; Nakamura, Yasuyuki; Sutton-Tyrrell, Kim; Rodriquez, Beatriz L.; Kadota, Aya; Edmundowicz, Daniel; Willcox, Bradley J.; Choo, Jina; Katsumi, Nakata; Otake, Teruo; Kadowaki, Sayaka; Kuller, Lewis H.; Ueshima, Hirotusgu; Sekikawa, Akira.

In: American Journal of Clinical Nutrition, Vol. 90, No. 1, 01.07.2009, p. 49-55.

Research output: Contribution to journalArticle

Motoyama, KR, Curb, JD, Kadowaki, T, El-Saed, A, Abbott, RD, Okamura, T, Evans, RW, Nakamura, Y, Sutton-Tyrrell, K, Rodriquez, BL, Kadota, A, Edmundowicz, D, Willcox, BJ, Choo, J, Katsumi, N, Otake, T, Kadowaki, S, Kuller, LH, Ueshima, H & Sekikawa, A 2009, 'Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men', American Journal of Clinical Nutrition, vol. 90, no. 1, pp. 49-55. https://doi.org/10.3945/ajcn.2008.26761
Motoyama, Kenneth R. ; Curb, J. David ; Kadowaki, Takashi ; El-Saed, Aiman ; Abbott, Robert D. ; Okamura, Tomonori ; Evans, Rhobert W. ; Nakamura, Yasuyuki ; Sutton-Tyrrell, Kim ; Rodriquez, Beatriz L. ; Kadota, Aya ; Edmundowicz, Daniel ; Willcox, Bradley J. ; Choo, Jina ; Katsumi, Nakata ; Otake, Teruo ; Kadowaki, Sayaka ; Kuller, Lewis H. ; Ueshima, Hirotusgu ; Sekikawa, Akira. / Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men. In: American Journal of Clinical Nutrition. 2009 ; Vol. 90, No. 1. pp. 49-55.
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abstract = "Background: The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known. Objective: Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40-49 y. Design: We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used. Results: Serum n = 6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [β = -0.39 (P < 0.001), -0.38 (P < 0.001), and -0.33 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [β = -0.15 (P < 0.001), -0.22 (P < 0.001), and -0.13 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (β = 4.49, P < 0.001) and Japanese (β = 3.73, P < 0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (β = 2.15, P < 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (β = 2.68, P < 0.01). Conclusion: Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations.",
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T1 - Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men

AU - Motoyama, Kenneth R.

AU - Curb, J. David

AU - Kadowaki, Takashi

AU - El-Saed, Aiman

AU - Abbott, Robert D.

AU - Okamura, Tomonori

AU - Evans, Rhobert W.

AU - Nakamura, Yasuyuki

AU - Sutton-Tyrrell, Kim

AU - Rodriquez, Beatriz L.

AU - Kadota, Aya

AU - Edmundowicz, Daniel

AU - Willcox, Bradley J.

AU - Choo, Jina

AU - Katsumi, Nakata

AU - Otake, Teruo

AU - Kadowaki, Sayaka

AU - Kuller, Lewis H.

AU - Ueshima, Hirotusgu

AU - Sekikawa, Akira

PY - 2009/7/1

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N2 - Background: The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known. Objective: Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40-49 y. Design: We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used. Results: Serum n = 6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [β = -0.39 (P < 0.001), -0.38 (P < 0.001), and -0.33 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [β = -0.15 (P < 0.001), -0.22 (P < 0.001), and -0.13 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (β = 4.49, P < 0.001) and Japanese (β = 3.73, P < 0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (β = 2.15, P < 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (β = 2.68, P < 0.01). Conclusion: Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations.

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