Association of specific IgE to staphylococcal superantigens with the phenotype of chronic urticaria

Young Min Ye, Gyu Young Hur, Han Jung Park, Seung Hyun Kim, Hyun Mi Kim, Hae Sim Park

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

It has been well established that bacterial superantigens lead to the induction and aggravation of chronic inflammatory skin diseases. We investigated the clinical significance of serum specific immunoglobulin E (IgE) to the staphylococcal superantigens staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), and toxic shock syndrome toxin (TSST)-1 in patients with chronic urticaria (CU), focusing on the differences in these prevalences between aspirin-intolerant CU (AICU) and aspirin-tolerant CU (ATCU) patients. Aspirin sensitivity was confirmed by oral aspirin provocation test. There were 66 patients AICU and 117 patients ATCU in the study. Serum IgE antibodies specific for SEA, SEB, and TSST-1 were measured by the ImmunoCAP test and the patients were compared with 93 normal controls (NC). The prevalences of serum specific IgE to staphylococcal superantigens were significantly higher in CU than in NC patients (IgE to SEA, 13.7% vs. 5.4%; IgE to SEB, 12.0% vs. 4.3%; IgE to TSST-1, 18.0% vs. 6.5%; p< 0.05, respectively). The patients with specific IgE to SEA, SEB, and TSST-1 had higher serum total IgE levels and higher rates of atopy. Significant associations were noted between the prevalence of specific IgE to SEA and SEB and the HLA DQB1*0609 and DRB1*1302 alleles in the AICU group. We confirmed that a sub-population of patients with CU possesses serum IgE antibodies to SEA, SEB, and TSST-1. Particularly, the IgE immune response to TSST-1 is associated with aspirin sensitivity in CU patients.

Original languageEnglish
Pages (from-to)845-851
Number of pages7
JournalJournal of Korean Medical Science
Volume23
Issue number5
DOIs
Publication statusPublished - 2008 Oct 1
Externally publishedYes

Fingerprint

Superantigens
Urticaria
Immunoglobulin E
Aspirin
Phenotype
Serum
HLA-DRB1 Chains
Antibodies
Skin Diseases
Staphylococcal enterotoxin F
staphylococcal enterotoxin B
Staphylococcal enterotoxin A
Alleles

Keywords

  • Aspirin hypersensitivity
  • Chronic urticaria
  • Specific IgE
  • Superantigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of specific IgE to staphylococcal superantigens with the phenotype of chronic urticaria. / Ye, Young Min; Hur, Gyu Young; Park, Han Jung; Kim, Seung Hyun; Kim, Hyun Mi; Park, Hae Sim.

In: Journal of Korean Medical Science, Vol. 23, No. 5, 01.10.2008, p. 845-851.

Research output: Contribution to journalArticle

Ye, Young Min ; Hur, Gyu Young ; Park, Han Jung ; Kim, Seung Hyun ; Kim, Hyun Mi ; Park, Hae Sim. / Association of specific IgE to staphylococcal superantigens with the phenotype of chronic urticaria. In: Journal of Korean Medical Science. 2008 ; Vol. 23, No. 5. pp. 845-851.
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AB - It has been well established that bacterial superantigens lead to the induction and aggravation of chronic inflammatory skin diseases. We investigated the clinical significance of serum specific immunoglobulin E (IgE) to the staphylococcal superantigens staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), and toxic shock syndrome toxin (TSST)-1 in patients with chronic urticaria (CU), focusing on the differences in these prevalences between aspirin-intolerant CU (AICU) and aspirin-tolerant CU (ATCU) patients. Aspirin sensitivity was confirmed by oral aspirin provocation test. There were 66 patients AICU and 117 patients ATCU in the study. Serum IgE antibodies specific for SEA, SEB, and TSST-1 were measured by the ImmunoCAP test and the patients were compared with 93 normal controls (NC). The prevalences of serum specific IgE to staphylococcal superantigens were significantly higher in CU than in NC patients (IgE to SEA, 13.7% vs. 5.4%; IgE to SEB, 12.0% vs. 4.3%; IgE to TSST-1, 18.0% vs. 6.5%; p< 0.05, respectively). The patients with specific IgE to SEA, SEB, and TSST-1 had higher serum total IgE levels and higher rates of atopy. Significant associations were noted between the prevalence of specific IgE to SEA and SEB and the HLA DQB1*0609 and DRB1*1302 alleles in the AICU group. We confirmed that a sub-population of patients with CU possesses serum IgE antibodies to SEA, SEB, and TSST-1. Particularly, the IgE immune response to TSST-1 is associated with aspirin sensitivity in CU patients.

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