Abstract
It has been well established that bacterial superantigens lead to the induction and aggravation of chronic inflammatory skin diseases. We investigated the clinical significance of serum specific immunoglobulin E (IgE) to the staphylococcal superantigens staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), and toxic shock syndrome toxin (TSST)-1 in patients with chronic urticaria (CU), focusing on the differences in these prevalences between aspirin-intolerant CU (AICU) and aspirin-tolerant CU (ATCU) patients. Aspirin sensitivity was confirmed by oral aspirin provocation test. There were 66 patients AICU and 117 patients ATCU in the study. Serum IgE antibodies specific for SEA, SEB, and TSST-1 were measured by the ImmunoCAP test and the patients were compared with 93 normal controls (NC). The prevalences of serum specific IgE to staphylococcal superantigens were significantly higher in CU than in NC patients (IgE to SEA, 13.7% vs. 5.4%; IgE to SEB, 12.0% vs. 4.3%; IgE to TSST-1, 18.0% vs. 6.5%; p< 0.05, respectively). The patients with specific IgE to SEA, SEB, and TSST-1 had higher serum total IgE levels and higher rates of atopy. Significant associations were noted between the prevalence of specific IgE to SEA and SEB and the HLA DQB1*0609 and DRB1*1302 alleles in the AICU group. We confirmed that a sub-population of patients with CU possesses serum IgE antibodies to SEA, SEB, and TSST-1. Particularly, the IgE immune response to TSST-1 is associated with aspirin sensitivity in CU patients.
| Original language | English |
|---|---|
| Pages (from-to) | 845-851 |
| Number of pages | 7 |
| Journal | Journal of Korean Medical Science |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2008 Oct 1 |
| Externally published | Yes |
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Keywords
- Aspirin hypersensitivity
- Chronic urticaria
- Specific IgE
- Superantigens
ASJC Scopus subject areas
- Medicine(all)
Cite this
Association of specific IgE to staphylococcal superantigens with the phenotype of chronic urticaria. / Ye, Young Min; Hur, Gyu Young; Park, Han Jung; Kim, Seung Hyun; Kim, Hyun Mi; Park, Hae Sim.
In: Journal of Korean Medical Science, Vol. 23, No. 5, 01.10.2008, p. 845-851.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of specific IgE to staphylococcal superantigens with the phenotype of chronic urticaria
AU - Ye, Young Min
AU - Hur, Gyu Young
AU - Park, Han Jung
AU - Kim, Seung Hyun
AU - Kim, Hyun Mi
AU - Park, Hae Sim
PY - 2008/10/1
Y1 - 2008/10/1
N2 - It has been well established that bacterial superantigens lead to the induction and aggravation of chronic inflammatory skin diseases. We investigated the clinical significance of serum specific immunoglobulin E (IgE) to the staphylococcal superantigens staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), and toxic shock syndrome toxin (TSST)-1 in patients with chronic urticaria (CU), focusing on the differences in these prevalences between aspirin-intolerant CU (AICU) and aspirin-tolerant CU (ATCU) patients. Aspirin sensitivity was confirmed by oral aspirin provocation test. There were 66 patients AICU and 117 patients ATCU in the study. Serum IgE antibodies specific for SEA, SEB, and TSST-1 were measured by the ImmunoCAP test and the patients were compared with 93 normal controls (NC). The prevalences of serum specific IgE to staphylococcal superantigens were significantly higher in CU than in NC patients (IgE to SEA, 13.7% vs. 5.4%; IgE to SEB, 12.0% vs. 4.3%; IgE to TSST-1, 18.0% vs. 6.5%; p< 0.05, respectively). The patients with specific IgE to SEA, SEB, and TSST-1 had higher serum total IgE levels and higher rates of atopy. Significant associations were noted between the prevalence of specific IgE to SEA and SEB and the HLA DQB1*0609 and DRB1*1302 alleles in the AICU group. We confirmed that a sub-population of patients with CU possesses serum IgE antibodies to SEA, SEB, and TSST-1. Particularly, the IgE immune response to TSST-1 is associated with aspirin sensitivity in CU patients.
AB - It has been well established that bacterial superantigens lead to the induction and aggravation of chronic inflammatory skin diseases. We investigated the clinical significance of serum specific immunoglobulin E (IgE) to the staphylococcal superantigens staphylococcal enterotoxin A (SEA), staphylococcal enterotoxin B (SEB), and toxic shock syndrome toxin (TSST)-1 in patients with chronic urticaria (CU), focusing on the differences in these prevalences between aspirin-intolerant CU (AICU) and aspirin-tolerant CU (ATCU) patients. Aspirin sensitivity was confirmed by oral aspirin provocation test. There were 66 patients AICU and 117 patients ATCU in the study. Serum IgE antibodies specific for SEA, SEB, and TSST-1 were measured by the ImmunoCAP test and the patients were compared with 93 normal controls (NC). The prevalences of serum specific IgE to staphylococcal superantigens were significantly higher in CU than in NC patients (IgE to SEA, 13.7% vs. 5.4%; IgE to SEB, 12.0% vs. 4.3%; IgE to TSST-1, 18.0% vs. 6.5%; p< 0.05, respectively). The patients with specific IgE to SEA, SEB, and TSST-1 had higher serum total IgE levels and higher rates of atopy. Significant associations were noted between the prevalence of specific IgE to SEA and SEB and the HLA DQB1*0609 and DRB1*1302 alleles in the AICU group. We confirmed that a sub-population of patients with CU possesses serum IgE antibodies to SEA, SEB, and TSST-1. Particularly, the IgE immune response to TSST-1 is associated with aspirin sensitivity in CU patients.
KW - Aspirin hypersensitivity
KW - Chronic urticaria
KW - Specific IgE
KW - Superantigens
UR - http://www.scopus.com/inward/record.url?scp=56049088316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56049088316&partnerID=8YFLogxK
U2 - 10.3346/jkms.2008.23.5.845
DO - 10.3346/jkms.2008.23.5.845
M3 - Article
VL - 23
SP - 845
EP - 851
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 5
ER -