Abstract
Objective Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published literature from PubMed and Embase. Results We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR = 0.71, 95% CI = 0.51–0.99, P = 0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52–0.98, P = 0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR = 0.53, CI = 0.33–0.85, P = 0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion Our meta-analysis supports an association between F13A1 Val34Leu and RPL.
| Original language | English |
|---|---|
| Pages (from-to) | 234-240 |
| Number of pages | 7 |
| Journal | European Journal of Obstetrics Gynecology and Reproductive Biology |
| Volume | 215 |
| DOIs | |
| Publication status | Published - 2017 Aug 1 |
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Keywords
- F13A1 Val34Leu
- Meta-analysis
- Polymorphism
- Recurrent pregnancy loss
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology
Cite this
Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss : A meta-analysis. / Jung, Jae Hyun; Kim, Jae Hoon; Song, Gwan Gyu; Choi, Sungjae.
In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 215, 01.08.2017, p. 234-240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss
T2 - A meta-analysis
AU - Jung, Jae Hyun
AU - Kim, Jae Hoon
AU - Song, Gwan Gyu
AU - Choi, Sungjae
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Objective Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published literature from PubMed and Embase. Results We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR = 0.71, 95% CI = 0.51–0.99, P = 0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52–0.98, P = 0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR = 0.53, CI = 0.33–0.85, P = 0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion Our meta-analysis supports an association between F13A1 Val34Leu and RPL.
AB - Objective Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published literature from PubMed and Embase. Results We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR = 0.71, 95% CI = 0.51–0.99, P = 0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52–0.98, P = 0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR = 0.53, CI = 0.33–0.85, P = 0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion Our meta-analysis supports an association between F13A1 Val34Leu and RPL.
KW - F13A1 Val34Leu
KW - Meta-analysis
KW - Polymorphism
KW - Recurrent pregnancy loss
UR - http://www.scopus.com/inward/record.url?scp=85021672818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021672818&partnerID=8YFLogxK
U2 - 10.1016/j.ejogrb.2017.06.032
DO - 10.1016/j.ejogrb.2017.06.032
M3 - Article
C2 - 28683377
AN - SCOPUS:85021672818
VL - 215
SP - 234
EP - 240
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
SN - 0028-2243
ER -