Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss: A meta-analysis

Jae Hyun Jung, Jae Hoon Kim, Gwan Gyu Song, Sungjae Choi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published literature from PubMed and Embase. Results We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR = 0.71, 95% CI = 0.51–0.99, P = 0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52–0.98, P = 0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR = 0.53, CI = 0.33–0.85, P = 0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion Our meta-analysis supports an association between F13A1 Val34Leu and RPL.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume215
DOIs
Publication statusPublished - 2017 Aug 1

Fingerprint

Meta-Analysis
Pregnancy
Factor XIII
Blood Coagulation
Fibrin
PubMed

Keywords

  • F13A1 Val34Leu
  • Meta-analysis
  • Polymorphism
  • Recurrent pregnancy loss

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

@article{8c57224fb51f4adb86636d68e7fa3759,
title = "Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss: A meta-analysis",
abstract = "Objective Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published literature from PubMed and Embase. Results We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR = 0.71, 95{\%} CI = 0.51–0.99, P = 0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95{\%} CI = 0.52–0.98, P = 0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR = 0.53, CI = 0.33–0.85, P = 0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion Our meta-analysis supports an association between F13A1 Val34Leu and RPL.",
keywords = "F13A1 Val34Leu, Meta-analysis, Polymorphism, Recurrent pregnancy loss",
author = "Jung, {Jae Hyun} and Kim, {Jae Hoon} and Song, {Gwan Gyu} and Sungjae Choi",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.ejogrb.2017.06.032",
language = "English",
volume = "215",
pages = "234--240",
journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",
issn = "0028-2243",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Association of the F13A1 Val34Leu polymorphism and recurrent pregnancy loss

T2 - A meta-analysis

AU - Jung, Jae Hyun

AU - Kim, Jae Hoon

AU - Song, Gwan Gyu

AU - Choi, Sungjae

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objective Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published literature from PubMed and Embase. Results We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR = 0.71, 95% CI = 0.51–0.99, P = 0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52–0.98, P = 0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR = 0.53, CI = 0.33–0.85, P = 0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion Our meta-analysis supports an association between F13A1 Val34Leu and RPL.

AB - Objective Factor XIII (FXIII) plays role in stabilizing the linkage between fibrins during blood clotting and has been implicated in recurrent pregnancy loss (RPL). The relationship between the Val34Leu polymorphism in F13A1, which encodes the enzymatic subunit of FXIII, and RPL is unclear. The aim of this meta-analysis was to evaluate the association betweenF13A1 Val34Leu and the risk of RPL. Study design We performed a meta-analysis of 11 studies involving 1092 cases and 678 controls using published literature from PubMed and Embase. Results We detected an association in recessive (Val/Val vs. Val/Leu + Leu/Leu; OR = 0.71, 95% CI = 0.51–0.99, P = 0.04), and one of the two co-dominant (Val/Val vs. Val/Leu; OR = 0.71, 95% CI = 0.52–0.98, P = 0.03) models of in heritance. Subgroup analysis revealed that the F13A1 Val34Leu polymorphism was associated with RPL in Asians (Val vs. Leu; OR = 0.53, CI = 0.33–0.85, P = 0.01). However, there was no association between F13A1 Val34Leu and RPL in Europeans and South Americans. Conclusion Our meta-analysis supports an association between F13A1 Val34Leu and RPL.

KW - F13A1 Val34Leu

KW - Meta-analysis

KW - Polymorphism

KW - Recurrent pregnancy loss

UR - http://www.scopus.com/inward/record.url?scp=85021672818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021672818&partnerID=8YFLogxK

U2 - 10.1016/j.ejogrb.2017.06.032

DO - 10.1016/j.ejogrb.2017.06.032

M3 - Article

C2 - 28683377

AN - SCOPUS:85021672818

VL - 215

SP - 234

EP - 240

JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

SN - 0028-2243

ER -