Association of the oestrogen receptor α gene polymorphisms with disease onset in systematic lupus erythematosus

Y. J. Lee, K. S. Shin, S. W. Kang, C. K. Lee, B. Yoo, H. S. Cha, E. M. Koh, Seok-Jun Yoon, Juneyoung Lee

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: To evaluate the genetic influence of Pbull and Xbal polymorphisms of oestrogen receptor α (ORα) in patients with systemic lupus erythematosus (SLE) in Korea. Methods: Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using Pvull and Xbal restriction fragment length polymorphism. Comparison of the frequencies of alleles and genotypes was made in control and patient groups and in childhood onset and adult onset SLE subgroups. Results: Although the Pp genotype occurred more often in SLE patients than in controls (pc = 0.017), ORα genotype distributions of adult onset SLE did not differ significantly from controls. The PP, Pp, and xx genotypes occurred less often in childhood onset SLE (pc = 0.0045, 0.0498, and 0.0255, respectively) than in controls. Additionally, the PP genotype was less common in childhood onset than in adult onset SLE (p c = 0.016). SLE patients with the PP genotypes were older at disease onset than those with the other genotypes (p = 0.001). Patients with the Xx genotype had an earlier onset of SLE than those with the xx genotype (p = 0.025). The frequency of the combined ppXx genotype was greater in childhood onset SLE than in controls (pc = 0.0009) or adult onset SLE (p c = 0.027). The same trend was supported by subgroup analyses according to age at menarche and logistic multivariate analyses. Conclusions: ORα polymorphisms are significantly associated with the age at disease onset in Koreans with SLE.

Original languageEnglish
Pages (from-to)1244-1249
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume63
Issue number10
DOIs
Publication statusPublished - 2004 Oct 1

Fingerprint

Polymorphism
Estrogen Receptors
Systemic Lupus Erythematosus
Genes
Genotype
Logistics
Menarche
DNA
Korea
Age of Onset
Gene Frequency
Restriction Fragment Length Polymorphisms
Multivariate Analysis
Control Groups

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Association of the oestrogen receptor α gene polymorphisms with disease onset in systematic lupus erythematosus. / Lee, Y. J.; Shin, K. S.; Kang, S. W.; Lee, C. K.; Yoo, B.; Cha, H. S.; Koh, E. M.; Yoon, Seok-Jun; Lee, Juneyoung.

In: Annals of the Rheumatic Diseases, Vol. 63, No. 10, 01.10.2004, p. 1244-1249.

Research output: Contribution to journalArticle

Lee, Y. J. ; Shin, K. S. ; Kang, S. W. ; Lee, C. K. ; Yoo, B. ; Cha, H. S. ; Koh, E. M. ; Yoon, Seok-Jun ; Lee, Juneyoung. / Association of the oestrogen receptor α gene polymorphisms with disease onset in systematic lupus erythematosus. In: Annals of the Rheumatic Diseases. 2004 ; Vol. 63, No. 10. pp. 1244-1249.
@article{3c87585cef964bf281b7c6e3fa8f42da,
title = "Association of the oestrogen receptor α gene polymorphisms with disease onset in systematic lupus erythematosus",
abstract = "Objective: To evaluate the genetic influence of Pbull and Xbal polymorphisms of oestrogen receptor α (ORα) in patients with systemic lupus erythematosus (SLE) in Korea. Methods: Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using Pvull and Xbal restriction fragment length polymorphism. Comparison of the frequencies of alleles and genotypes was made in control and patient groups and in childhood onset and adult onset SLE subgroups. Results: Although the Pp genotype occurred more often in SLE patients than in controls (pc = 0.017), ORα genotype distributions of adult onset SLE did not differ significantly from controls. The PP, Pp, and xx genotypes occurred less often in childhood onset SLE (pc = 0.0045, 0.0498, and 0.0255, respectively) than in controls. Additionally, the PP genotype was less common in childhood onset than in adult onset SLE (p c = 0.016). SLE patients with the PP genotypes were older at disease onset than those with the other genotypes (p = 0.001). Patients with the Xx genotype had an earlier onset of SLE than those with the xx genotype (p = 0.025). The frequency of the combined ppXx genotype was greater in childhood onset SLE than in controls (pc = 0.0009) or adult onset SLE (p c = 0.027). The same trend was supported by subgroup analyses according to age at menarche and logistic multivariate analyses. Conclusions: ORα polymorphisms are significantly associated with the age at disease onset in Koreans with SLE.",
author = "Lee, {Y. J.} and Shin, {K. S.} and Kang, {S. W.} and Lee, {C. K.} and B. Yoo and Cha, {H. S.} and Koh, {E. M.} and Seok-Jun Yoon and Juneyoung Lee",
year = "2004",
month = "10",
day = "1",
doi = "10.1136/ard.2003.012583",
language = "English",
volume = "63",
pages = "1244--1249",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "10",

}

TY - JOUR

T1 - Association of the oestrogen receptor α gene polymorphisms with disease onset in systematic lupus erythematosus

AU - Lee, Y. J.

AU - Shin, K. S.

AU - Kang, S. W.

AU - Lee, C. K.

AU - Yoo, B.

AU - Cha, H. S.

AU - Koh, E. M.

AU - Yoon, Seok-Jun

AU - Lee, Juneyoung

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Objective: To evaluate the genetic influence of Pbull and Xbal polymorphisms of oestrogen receptor α (ORα) in patients with systemic lupus erythematosus (SLE) in Korea. Methods: Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using Pvull and Xbal restriction fragment length polymorphism. Comparison of the frequencies of alleles and genotypes was made in control and patient groups and in childhood onset and adult onset SLE subgroups. Results: Although the Pp genotype occurred more often in SLE patients than in controls (pc = 0.017), ORα genotype distributions of adult onset SLE did not differ significantly from controls. The PP, Pp, and xx genotypes occurred less often in childhood onset SLE (pc = 0.0045, 0.0498, and 0.0255, respectively) than in controls. Additionally, the PP genotype was less common in childhood onset than in adult onset SLE (p c = 0.016). SLE patients with the PP genotypes were older at disease onset than those with the other genotypes (p = 0.001). Patients with the Xx genotype had an earlier onset of SLE than those with the xx genotype (p = 0.025). The frequency of the combined ppXx genotype was greater in childhood onset SLE than in controls (pc = 0.0009) or adult onset SLE (p c = 0.027). The same trend was supported by subgroup analyses according to age at menarche and logistic multivariate analyses. Conclusions: ORα polymorphisms are significantly associated with the age at disease onset in Koreans with SLE.

AB - Objective: To evaluate the genetic influence of Pbull and Xbal polymorphisms of oestrogen receptor α (ORα) in patients with systemic lupus erythematosus (SLE) in Korea. Methods: Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using Pvull and Xbal restriction fragment length polymorphism. Comparison of the frequencies of alleles and genotypes was made in control and patient groups and in childhood onset and adult onset SLE subgroups. Results: Although the Pp genotype occurred more often in SLE patients than in controls (pc = 0.017), ORα genotype distributions of adult onset SLE did not differ significantly from controls. The PP, Pp, and xx genotypes occurred less often in childhood onset SLE (pc = 0.0045, 0.0498, and 0.0255, respectively) than in controls. Additionally, the PP genotype was less common in childhood onset than in adult onset SLE (p c = 0.016). SLE patients with the PP genotypes were older at disease onset than those with the other genotypes (p = 0.001). Patients with the Xx genotype had an earlier onset of SLE than those with the xx genotype (p = 0.025). The frequency of the combined ppXx genotype was greater in childhood onset SLE than in controls (pc = 0.0009) or adult onset SLE (p c = 0.027). The same trend was supported by subgroup analyses according to age at menarche and logistic multivariate analyses. Conclusions: ORα polymorphisms are significantly associated with the age at disease onset in Koreans with SLE.

UR - http://www.scopus.com/inward/record.url?scp=4644289773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644289773&partnerID=8YFLogxK

U2 - 10.1136/ard.2003.012583

DO - 10.1136/ard.2003.012583

M3 - Article

C2 - 15361380

AN - SCOPUS:4644289773

VL - 63

SP - 1244

EP - 1249

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 10

ER -