Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma

Nami Shrestha Palikhe, Seung Hyun Kim, Bo Young Cho, Young Min Ye, Gyu Young Hur, Hae Sim Park

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background and objective: The high-affinity IgE receptor comprises a tetramer of the ligand-binding alpha chain, a signal-augmenting beta chain, and a signal-transducing gamma chain dimer on mast cells. We hypothesized that the three subsets of the FCER1 gene may play a role in the development of the aspirin-intolerant asthma (AIA) phenotype and analyzed these genetic polymorphisms in association with clinical parameters in AIA patients. Subjects and methods: Six polymorphisms of FCER1 (FCERIA-344C>T, FCER1A-95T>C, MS4A2-109T>C, MS4A2 E237G, FCER1G-237A>G, FCER1G-54G>T) were genotyped in 126 AIA patients compared to 177 patients with aspirin-tolerant asthma (ATA) and 222 normal health controls (NC). Results: A significant difference in the genotype frequencies of FCER1G-237A>G was detected between AIA and ATA patients (p < 0.05) both in co-dominant and recessive analysis models, whereas no significant relationships were identified between the frequencies of the other five single-nucleotide polymorphisms and AIA, ATA, and NC subjects. In addition, AIA patients carrying the homozygous AA genotype of FCER1G-237A>G exhibited significantly higher total serum IgE levels than did those with the GG/AG genotype (p = 0.012). AIA patients expressing the CT/TT genotype at FCERIA-344C>T showed a higher prevalence of serum IgE specific to Staphylococcal enterotoxin A than did those with the CC genotype (p = 0.008). Conclusion: The FCER1G-237A>G and FCERIA-344C>T polymorphisms may contribute to the development of AIA in a Korean population.

Original languageEnglish
Pages (from-to)1132-1139
Number of pages8
JournalRespiratory Medicine
Volume102
Issue number8
DOIs
Publication statusPublished - 2008 Aug
Externally publishedYes

Keywords

  • Aspirin-intolerant asthma
  • FCER1A
  • FCER1G
  • MS4A2
  • Serum total IgE
  • Specific IgE to Staphylococcal superantigen

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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