Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma

Nami Shrestha Palikhe, Seung Hyun Kim, Bo Young Cho, Young Min Ye, Gyu Young Hur, Hae Sim Park

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background and objective: The high-affinity IgE receptor comprises a tetramer of the ligand-binding alpha chain, a signal-augmenting beta chain, and a signal-transducing gamma chain dimer on mast cells. We hypothesized that the three subsets of the FCER1 gene may play a role in the development of the aspirin-intolerant asthma (AIA) phenotype and analyzed these genetic polymorphisms in association with clinical parameters in AIA patients. Subjects and methods: Six polymorphisms of FCER1 (FCERIA-344C>T, FCER1A-95T>C, MS4A2-109T>C, MS4A2 E237G, FCER1G-237A>G, FCER1G-54G>T) were genotyped in 126 AIA patients compared to 177 patients with aspirin-tolerant asthma (ATA) and 222 normal health controls (NC). Results: A significant difference in the genotype frequencies of FCER1G-237A>G was detected between AIA and ATA patients (p < 0.05) both in co-dominant and recessive analysis models, whereas no significant relationships were identified between the frequencies of the other five single-nucleotide polymorphisms and AIA, ATA, and NC subjects. In addition, AIA patients carrying the homozygous AA genotype of FCER1G-237A>G exhibited significantly higher total serum IgE levels than did those with the GG/AG genotype (p = 0.012). AIA patients expressing the CT/TT genotype at FCERIA-344C>T showed a higher prevalence of serum IgE specific to Staphylococcal enterotoxin A than did those with the CC genotype (p = 0.008). Conclusion: The FCER1G-237A>G and FCERIA-344C>T polymorphisms may contribute to the development of AIA in a Korean population.

Original languageEnglish
Pages (from-to)1132-1139
Number of pages8
JournalRespiratory Medicine
Volume102
Issue number8
DOIs
Publication statusPublished - 2008 Aug 1
Externally publishedYes

Fingerprint

IgE Receptors
Aspirin
Asthma
Genotype
Immunoglobulin E
Genetic Polymorphisms
Serum
Mast Cells
Ligands
Phenotype
Health

Keywords

  • Aspirin-intolerant asthma
  • FCER1A
  • FCER1G
  • MS4A2
  • Serum total IgE
  • Specific IgE to Staphylococcal superantigen

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. / Palikhe, Nami Shrestha; Kim, Seung Hyun; Cho, Bo Young; Ye, Young Min; Hur, Gyu Young; Park, Hae Sim.

In: Respiratory Medicine, Vol. 102, No. 8, 01.08.2008, p. 1132-1139.

Research output: Contribution to journalArticle

Palikhe, Nami Shrestha ; Kim, Seung Hyun ; Cho, Bo Young ; Ye, Young Min ; Hur, Gyu Young ; Park, Hae Sim. / Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. In: Respiratory Medicine. 2008 ; Vol. 102, No. 8. pp. 1132-1139.
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T1 - Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma

AU - Palikhe, Nami Shrestha

AU - Kim, Seung Hyun

AU - Cho, Bo Young

AU - Ye, Young Min

AU - Hur, Gyu Young

AU - Park, Hae Sim

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AB - Background and objective: The high-affinity IgE receptor comprises a tetramer of the ligand-binding alpha chain, a signal-augmenting beta chain, and a signal-transducing gamma chain dimer on mast cells. We hypothesized that the three subsets of the FCER1 gene may play a role in the development of the aspirin-intolerant asthma (AIA) phenotype and analyzed these genetic polymorphisms in association with clinical parameters in AIA patients. Subjects and methods: Six polymorphisms of FCER1 (FCERIA-344C>T, FCER1A-95T>C, MS4A2-109T>C, MS4A2 E237G, FCER1G-237A>G, FCER1G-54G>T) were genotyped in 126 AIA patients compared to 177 patients with aspirin-tolerant asthma (ATA) and 222 normal health controls (NC). Results: A significant difference in the genotype frequencies of FCER1G-237A>G was detected between AIA and ATA patients (p < 0.05) both in co-dominant and recessive analysis models, whereas no significant relationships were identified between the frequencies of the other five single-nucleotide polymorphisms and AIA, ATA, and NC subjects. In addition, AIA patients carrying the homozygous AA genotype of FCER1G-237A>G exhibited significantly higher total serum IgE levels than did those with the GG/AG genotype (p = 0.012). AIA patients expressing the CT/TT genotype at FCERIA-344C>T showed a higher prevalence of serum IgE specific to Staphylococcal enterotoxin A than did those with the CC genotype (p = 0.008). Conclusion: The FCER1G-237A>G and FCERIA-344C>T polymorphisms may contribute to the development of AIA in a Korean population.

KW - Aspirin-intolerant asthma

KW - FCER1A

KW - FCER1G

KW - MS4A2

KW - Serum total IgE

KW - Specific IgE to Staphylococcal superantigen

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