Association of up-regulated plasma adiponectin with risk of incident depression in a community-dwelling elderly population

Dae Jong Oh, Ji Won Han, Beom Jun Min, Hyun-Ghang Jeong, Tae Hui Kim, Sung Hee Choi, Soo Lim, Jung Jae Lee, Joon Hyuk Park, Seok Bum Lee, Young Joo Park, Hak Chul Jang, Ki Woong Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Despite robust interest in the association between inflammation and depression, anti-inflammatory markers have been scarcely investigated as predictors of the future risk of depression. The aim of this study is to determine whether up-regulation of plasma adiponectin, an anti-inflammatory adipokine, precedes and predicts the development of depression in the elderly. Methods: This prospective cohort study was launched in 2005. Among 1,000 participants who were randomly sampled from community-dwelling individuals 65 years or older, 633 euthymic individuals without prior history of depressive disorders were enrolled for a baseline evaluation and follow-up after 5 years. Incident clinically significant depression, including major and minor depressive disorders (by DSM-IV criteria), subsyndromal depression (by operational criteria), and euthymia after antidepressant treatment, was assessed by clinical interviews. Results: Baseline plasma adiponectin values were divided into tertiles (low tertile: ≤ 5.685 μg/mL, middle tertile: 5.686-10.367 μg/mL, high tertile: ≥ 10.368 μg/mL). Among the 261 euthymic individuals who responded to the 5-year follow-up evaluation, 17 developed incident depression (7 from the high tertile, 8 from the middle tertile, and 2 from the low tertile). The risk of incident depression was much higher in the high tertile group than in the low tertile group after adjusting for age, sex, body mass index, burden of chronic medical illnesses, and Mini-Mental State Examination score (odds ratio = 10.64; 95% CI, 1.21-93.84; P = .033). Conclusions: Up-regulation of plasma adiponectin may precede the onset of clinically significant depression in the elderly, and thus plasma adiponectin level is a potential candidate marker for the risk of depression.

Original languageEnglish
Article number17m11695
JournalJournal of Clinical Psychiatry
Volume79
Issue number3
DOIs
Publication statusPublished - 2018 May 1

Fingerprint

Independent Living
Adiponectin
Depression
Population
Anti-Inflammatory Agents
Up-Regulation
Adipokines
Major Depressive Disorder
Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Antidepressive Agents
Body Mass Index
Chronic Disease
Cohort Studies
Odds Ratio
Prospective Studies
Interviews
Inflammation

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Association of up-regulated plasma adiponectin with risk of incident depression in a community-dwelling elderly population. / Oh, Dae Jong; Han, Ji Won; Min, Beom Jun; Jeong, Hyun-Ghang; Kim, Tae Hui; Choi, Sung Hee; Lim, Soo; Lee, Jung Jae; Park, Joon Hyuk; Lee, Seok Bum; Park, Young Joo; Jang, Hak Chul; Kim, Ki Woong.

In: Journal of Clinical Psychiatry, Vol. 79, No. 3, 17m11695, 01.05.2018.

Research output: Contribution to journalArticle

Oh, DJ, Han, JW, Min, BJ, Jeong, H-G, Kim, TH, Choi, SH, Lim, S, Lee, JJ, Park, JH, Lee, SB, Park, YJ, Jang, HC & Kim, KW 2018, 'Association of up-regulated plasma adiponectin with risk of incident depression in a community-dwelling elderly population', Journal of Clinical Psychiatry, vol. 79, no. 3, 17m11695. https://doi.org/10.4088/JCP.17m11695
Oh, Dae Jong ; Han, Ji Won ; Min, Beom Jun ; Jeong, Hyun-Ghang ; Kim, Tae Hui ; Choi, Sung Hee ; Lim, Soo ; Lee, Jung Jae ; Park, Joon Hyuk ; Lee, Seok Bum ; Park, Young Joo ; Jang, Hak Chul ; Kim, Ki Woong. / Association of up-regulated plasma adiponectin with risk of incident depression in a community-dwelling elderly population. In: Journal of Clinical Psychiatry. 2018 ; Vol. 79, No. 3.
@article{a6ba1b524550490c8eb2310196a18bb0,
title = "Association of up-regulated plasma adiponectin with risk of incident depression in a community-dwelling elderly population",
abstract = "Objective: Despite robust interest in the association between inflammation and depression, anti-inflammatory markers have been scarcely investigated as predictors of the future risk of depression. The aim of this study is to determine whether up-regulation of plasma adiponectin, an anti-inflammatory adipokine, precedes and predicts the development of depression in the elderly. Methods: This prospective cohort study was launched in 2005. Among 1,000 participants who were randomly sampled from community-dwelling individuals 65 years or older, 633 euthymic individuals without prior history of depressive disorders were enrolled for a baseline evaluation and follow-up after 5 years. Incident clinically significant depression, including major and minor depressive disorders (by DSM-IV criteria), subsyndromal depression (by operational criteria), and euthymia after antidepressant treatment, was assessed by clinical interviews. Results: Baseline plasma adiponectin values were divided into tertiles (low tertile: ≤ 5.685 μg/mL, middle tertile: 5.686-10.367 μg/mL, high tertile: ≥ 10.368 μg/mL). Among the 261 euthymic individuals who responded to the 5-year follow-up evaluation, 17 developed incident depression (7 from the high tertile, 8 from the middle tertile, and 2 from the low tertile). The risk of incident depression was much higher in the high tertile group than in the low tertile group after adjusting for age, sex, body mass index, burden of chronic medical illnesses, and Mini-Mental State Examination score (odds ratio = 10.64; 95{\%} CI, 1.21-93.84; P = .033). Conclusions: Up-regulation of plasma adiponectin may precede the onset of clinically significant depression in the elderly, and thus plasma adiponectin level is a potential candidate marker for the risk of depression.",
author = "Oh, {Dae Jong} and Han, {Ji Won} and Min, {Beom Jun} and Hyun-Ghang Jeong and Kim, {Tae Hui} and Choi, {Sung Hee} and Soo Lim and Lee, {Jung Jae} and Park, {Joon Hyuk} and Lee, {Seok Bum} and Park, {Young Joo} and Jang, {Hak Chul} and Kim, {Ki Woong}",
year = "2018",
month = "5",
day = "1",
doi = "10.4088/JCP.17m11695",
language = "English",
volume = "79",
journal = "Journal of Clinical Psychiatry",
issn = "0160-6689",
publisher = "Physicians Postgraduate Press Inc.",
number = "3",

}

TY - JOUR

T1 - Association of up-regulated plasma adiponectin with risk of incident depression in a community-dwelling elderly population

AU - Oh, Dae Jong

AU - Han, Ji Won

AU - Min, Beom Jun

AU - Jeong, Hyun-Ghang

AU - Kim, Tae Hui

AU - Choi, Sung Hee

AU - Lim, Soo

AU - Lee, Jung Jae

AU - Park, Joon Hyuk

AU - Lee, Seok Bum

AU - Park, Young Joo

AU - Jang, Hak Chul

AU - Kim, Ki Woong

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Objective: Despite robust interest in the association between inflammation and depression, anti-inflammatory markers have been scarcely investigated as predictors of the future risk of depression. The aim of this study is to determine whether up-regulation of plasma adiponectin, an anti-inflammatory adipokine, precedes and predicts the development of depression in the elderly. Methods: This prospective cohort study was launched in 2005. Among 1,000 participants who were randomly sampled from community-dwelling individuals 65 years or older, 633 euthymic individuals without prior history of depressive disorders were enrolled for a baseline evaluation and follow-up after 5 years. Incident clinically significant depression, including major and minor depressive disorders (by DSM-IV criteria), subsyndromal depression (by operational criteria), and euthymia after antidepressant treatment, was assessed by clinical interviews. Results: Baseline plasma adiponectin values were divided into tertiles (low tertile: ≤ 5.685 μg/mL, middle tertile: 5.686-10.367 μg/mL, high tertile: ≥ 10.368 μg/mL). Among the 261 euthymic individuals who responded to the 5-year follow-up evaluation, 17 developed incident depression (7 from the high tertile, 8 from the middle tertile, and 2 from the low tertile). The risk of incident depression was much higher in the high tertile group than in the low tertile group after adjusting for age, sex, body mass index, burden of chronic medical illnesses, and Mini-Mental State Examination score (odds ratio = 10.64; 95% CI, 1.21-93.84; P = .033). Conclusions: Up-regulation of plasma adiponectin may precede the onset of clinically significant depression in the elderly, and thus plasma adiponectin level is a potential candidate marker for the risk of depression.

AB - Objective: Despite robust interest in the association between inflammation and depression, anti-inflammatory markers have been scarcely investigated as predictors of the future risk of depression. The aim of this study is to determine whether up-regulation of plasma adiponectin, an anti-inflammatory adipokine, precedes and predicts the development of depression in the elderly. Methods: This prospective cohort study was launched in 2005. Among 1,000 participants who were randomly sampled from community-dwelling individuals 65 years or older, 633 euthymic individuals without prior history of depressive disorders were enrolled for a baseline evaluation and follow-up after 5 years. Incident clinically significant depression, including major and minor depressive disorders (by DSM-IV criteria), subsyndromal depression (by operational criteria), and euthymia after antidepressant treatment, was assessed by clinical interviews. Results: Baseline plasma adiponectin values were divided into tertiles (low tertile: ≤ 5.685 μg/mL, middle tertile: 5.686-10.367 μg/mL, high tertile: ≥ 10.368 μg/mL). Among the 261 euthymic individuals who responded to the 5-year follow-up evaluation, 17 developed incident depression (7 from the high tertile, 8 from the middle tertile, and 2 from the low tertile). The risk of incident depression was much higher in the high tertile group than in the low tertile group after adjusting for age, sex, body mass index, burden of chronic medical illnesses, and Mini-Mental State Examination score (odds ratio = 10.64; 95% CI, 1.21-93.84; P = .033). Conclusions: Up-regulation of plasma adiponectin may precede the onset of clinically significant depression in the elderly, and thus plasma adiponectin level is a potential candidate marker for the risk of depression.

UR - http://www.scopus.com/inward/record.url?scp=85049467444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049467444&partnerID=8YFLogxK

U2 - 10.4088/JCP.17m11695

DO - 10.4088/JCP.17m11695

M3 - Article

VL - 79

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

SN - 0160-6689

IS - 3

M1 - 17m11695

ER -