TY - JOUR
T1 - Association of up-regulated plasma adiponectin with risk of incident depression in a community-dwelling elderly population
AU - Oh, Dae Jong
AU - Han, Ji Won
AU - Min, Beom Jun
AU - Jeong, Hyun Ghang
AU - Kim, Tae Hui
AU - Choi, Sung Hee
AU - Lim, Soo
AU - Lee, Jung Jae
AU - Park, Joon Hyuk
AU - Lee, Seok Bum
AU - Park, Young Joo
AU - Jang, Hak Chul
AU - Kim, Ki Woong
N1 - Funding Information:
Funding/support: This study was supported by regulates the growth of myelomonocytic solubledefensecollagens,negatively a grant from the Korean Health Technology R&D progenitors and the functions of Project, Ministry for Health, Welfare, and Family macrophages. Blood. 2000;96(5):1723–1732.PubMed Affairs, Republic of Korea (grant no. A092077). Jeong HG, Min BJ, Lim S, et al. Plasma Role of the sponsor: The funding organization adiponectin elevation in elderly individuals had no role in study design, data collection and with subsyndromal depression. analysis, decision to submit, or preparation of the Psychoneuroendocrinology. manuscript. 2012;37(7):948–955.PubMed CrossRef 10. Hung YJ, Hsieh CH, Chen YJ, et al. Insulin
Publisher Copyright:
© Copyright 2018 Physicians Postgraduate Press, Inc.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Objective: Despite robust interest in the association between inflammation and depression, anti-inflammatory markers have been scarcely investigated as predictors of the future risk of depression. The aim of this study is to determine whether up-regulation of plasma adiponectin, an anti-inflammatory adipokine, precedes and predicts the development of depression in the elderly. Methods: This prospective cohort study was launched in 2005. Among 1,000 participants who were randomly sampled from community-dwelling individuals 65 years or older, 633 euthymic individuals without prior history of depressive disorders were enrolled for a baseline evaluation and follow-up after 5 years. Incident clinically significant depression, including major and minor depressive disorders (by DSM-IV criteria), subsyndromal depression (by operational criteria), and euthymia after antidepressant treatment, was assessed by clinical interviews. Results: Baseline plasma adiponectin values were divided into tertiles (low tertile: ≤ 5.685 μg/mL, middle tertile: 5.686-10.367 μg/mL, high tertile: ≥ 10.368 μg/mL). Among the 261 euthymic individuals who responded to the 5-year follow-up evaluation, 17 developed incident depression (7 from the high tertile, 8 from the middle tertile, and 2 from the low tertile). The risk of incident depression was much higher in the high tertile group than in the low tertile group after adjusting for age, sex, body mass index, burden of chronic medical illnesses, and Mini-Mental State Examination score (odds ratio = 10.64; 95% CI, 1.21-93.84; P = .033). Conclusions: Up-regulation of plasma adiponectin may precede the onset of clinically significant depression in the elderly, and thus plasma adiponectin level is a potential candidate marker for the risk of depression.
AB - Objective: Despite robust interest in the association between inflammation and depression, anti-inflammatory markers have been scarcely investigated as predictors of the future risk of depression. The aim of this study is to determine whether up-regulation of plasma adiponectin, an anti-inflammatory adipokine, precedes and predicts the development of depression in the elderly. Methods: This prospective cohort study was launched in 2005. Among 1,000 participants who were randomly sampled from community-dwelling individuals 65 years or older, 633 euthymic individuals without prior history of depressive disorders were enrolled for a baseline evaluation and follow-up after 5 years. Incident clinically significant depression, including major and minor depressive disorders (by DSM-IV criteria), subsyndromal depression (by operational criteria), and euthymia after antidepressant treatment, was assessed by clinical interviews. Results: Baseline plasma adiponectin values were divided into tertiles (low tertile: ≤ 5.685 μg/mL, middle tertile: 5.686-10.367 μg/mL, high tertile: ≥ 10.368 μg/mL). Among the 261 euthymic individuals who responded to the 5-year follow-up evaluation, 17 developed incident depression (7 from the high tertile, 8 from the middle tertile, and 2 from the low tertile). The risk of incident depression was much higher in the high tertile group than in the low tertile group after adjusting for age, sex, body mass index, burden of chronic medical illnesses, and Mini-Mental State Examination score (odds ratio = 10.64; 95% CI, 1.21-93.84; P = .033). Conclusions: Up-regulation of plasma adiponectin may precede the onset of clinically significant depression in the elderly, and thus plasma adiponectin level is a potential candidate marker for the risk of depression.
UR - http://www.scopus.com/inward/record.url?scp=85049467444&partnerID=8YFLogxK
U2 - 10.4088/JCP.17m11695
DO - 10.4088/JCP.17m11695
M3 - Article
C2 - 29702755
AN - SCOPUS:85049467444
VL - 79
JO - Diseases of the Nervous System
JF - Diseases of the Nervous System
SN - 0160-6689
IS - 3
M1 - 17m11695
ER -