Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy

Min Young Chun, Hwan Sik Hwang, Hee Youn Cho, Ha Jung Chun, Jung Taek Woo, Kwan Woo Lee, Mun Suk Nam, Sei-Hyun Baik, Young Seol Kim, Yongsoo Park

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Abstract

Context: Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor, and its polymorphisms are associated with proliferative diabetic retinopathy (PDR) and macular edema. Objective: We investigated the contributions of VEGF gene polymorphisms to nonproliferative diabetic retinopathy (NPDR) as well as PDR. Design, Setting, and Subjects: In this study we compared VEGF genevariants in a sample of Korean type 2 diabetes patients with and without diabetic retinopathy (DR)and in healthy controls. Of the diabetes patients, 145 had PDR, 108 had NPDR, and 134 had no retinopathy (noDR). They were all duration matched. Samples were genotyped for rs699947, rs1570360, and rs2010963 polymorphisms. Results: We found a significant association between the A allele at rs699947 with DR (odds ratio = 1.84 (95% confidence interval = 1.28-2.66); P = 0.001 vs. noDR). Patients with NPDR, as well as PDR, had increased incidence of the A allele. The AGG haplotype was more frequently found in patients with DR than in patients with noDR (odds ratio = 4.79 (95% confidence interval = 1.42-16.16); P = 0.006). PDR and NPDR patients exhibited an increased incidence of the AGG haplotype. Conclusions: VEGF polymorphisms might be a useful predictive marker for the development and progression of DR at an earlier stage of diabetes.

Original languageEnglish
Pages (from-to)3547-3551
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume95
Issue number7
DOIs
Publication statusPublished - 2010 Jan 1

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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