Association study between 5-HTIA receptor gene C(-1019)G polymorphism and panic disorder in a Korean population

Won Seok Choi, Bun Hee Lee, Jong Chul Yang, Yong Ku Kim

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    18 Citations (Scopus)

    Abstract

    Objective: Serotonergic dysfunction is quite evident in panic disorder. We investigated whether the C(-1019)G polymorphism of 5-HT1A receptor gene may play a role in the pathogenesis of panic disorder in a Korean population. Methods: The 5-HT1A receptor genotype for the single nucleotide polymorphism (SNP) C(-1019)G was analyzed in 94 patients and 111 healthy controls. The severity of the patients' symptoms was examined using the Spielberger State-Trait Anxiety Inventory (STAI), Panic Disorder Severity Scale (PDSS), Anxiety sensitivity index (ASI), Acute Panic Inventory (API) and Hamilton's Rating Scale for Anxiety (HAM-A). Results: The distribution of the genotypes of the C/G polymorphism did not differ significantly from those predicted by Hardy-Weinberg equilibrium in patients as well as the controls. No association between the C(-1019)G polymorphism and panic disorder was detected in either the allele frequency or genotype distribution. There was no significant association with genotype distribution in the panic disorder with agoraphobia. However, there was a significant difference of symptom severity between C/C, C/G, and G/G genotype or between C and G allele in panic disorder patients without agoraphobia. PDSS scores were significantly higher in subjects with the G/G genotype or with G allele in patients without agoraphobia, not in total patients or patients with agoraphobia. Conclusion: Although there were no significant differences in the genotype and allele distributions, we found a significant association between panic symptom severity and the serotonin 1A receptor gene. This result suggests that the serotonin 1A receptor and serotonin may play a role in the pathogenesis of panic disorder.

    Original languageEnglish
    Pages (from-to)141-146
    Number of pages6
    JournalPsychiatry Investigation
    Volume7
    Issue number2
    DOIs
    Publication statusPublished - 2010 Jun

    Keywords

    • 5-HT1A gene
    • Agoraphobia
    • Association
    • Panic disorder
    • Polymorphism

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry

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