Association study of dopamine receptor D2TaqI A polymorphism and reward-related personality traits in healthy Korean young females

So Hee Lee, Byung-Joo Ham, Youl Hee Cho, Seung Min Lee, Sung Han Shim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Genetic factors make a significant contribution to the determination of human personality traits. We aimed to investigate the possible relationship between dopamine receptor D2 (DRD2) TaqI A polymorphism and the reward-related personality traits as measured by the Carver and White Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and Cloninger's Temperament and Character Inventory (TCI). Methods: The sample consisted of 267 female healthy Korean unrelated university students (age: 23.12 ± 3.22 years) and they filled out the BIS/BAS scales and the TCI. Genomic DNA was isolated from whole blood and genotyped with the fluorescence polarization detection method. The effect of the independent variables (DRD2 genotypes) on the dependent variables were analyzed by multivariate and subsequent univariate ANOVA. Results: We found significant associations between the A1 allele of the DRD2 TaqI A polymorphism and a high BAS-RR score (reward responsiveness). No significant association was observed between DRD2 polymorphisms and other factors of the BIS/BAS scales and TCI. Conclusion: These findings suggest the notion that DRD2 TaqI A polymorphism contributes to high reward sensitivity, which measures anticipation and positive response towards reward.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalNeuropsychobiology
Volume56
Issue number2-3
DOIs
Publication statusPublished - 2008 Feb 1
Externally publishedYes

Fingerprint

Dopamine D2 Receptors
Dopamine Receptors
Reward
Temperament
Personality
Equipment and Supplies
Fluorescence Polarization
Analysis of Variance
Alleles
Genotype
Students
DNA
Inhibition (Psychology)

Keywords

  • Behavioral approach system
  • Dopamine receptor DTaqI A polymorphism
  • Personality traits

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Association study of dopamine receptor D2TaqI A polymorphism and reward-related personality traits in healthy Korean young females. / Lee, So Hee; Ham, Byung-Joo; Cho, Youl Hee; Lee, Seung Min; Shim, Sung Han.

In: Neuropsychobiology, Vol. 56, No. 2-3, 01.02.2008, p. 146-151.

Research output: Contribution to journalArticle

Lee, So Hee ; Ham, Byung-Joo ; Cho, Youl Hee ; Lee, Seung Min ; Shim, Sung Han. / Association study of dopamine receptor D2TaqI A polymorphism and reward-related personality traits in healthy Korean young females. In: Neuropsychobiology. 2008 ; Vol. 56, No. 2-3. pp. 146-151.
@article{05b1945bc6c3450ebc8539e9570b9925,
title = "Association study of dopamine receptor D2TaqI A polymorphism and reward-related personality traits in healthy Korean young females",
abstract = "Background: Genetic factors make a significant contribution to the determination of human personality traits. We aimed to investigate the possible relationship between dopamine receptor D2 (DRD2) TaqI A polymorphism and the reward-related personality traits as measured by the Carver and White Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and Cloninger's Temperament and Character Inventory (TCI). Methods: The sample consisted of 267 female healthy Korean unrelated university students (age: 23.12 ± 3.22 years) and they filled out the BIS/BAS scales and the TCI. Genomic DNA was isolated from whole blood and genotyped with the fluorescence polarization detection method. The effect of the independent variables (DRD2 genotypes) on the dependent variables were analyzed by multivariate and subsequent univariate ANOVA. Results: We found significant associations between the A1 allele of the DRD2 TaqI A polymorphism and a high BAS-RR score (reward responsiveness). No significant association was observed between DRD2 polymorphisms and other factors of the BIS/BAS scales and TCI. Conclusion: These findings suggest the notion that DRD2 TaqI A polymorphism contributes to high reward sensitivity, which measures anticipation and positive response towards reward.",
keywords = "Behavioral approach system, Dopamine receptor DTaqI A polymorphism, Personality traits",
author = "Lee, {So Hee} and Byung-Joo Ham and Cho, {Youl Hee} and Lee, {Seung Min} and Shim, {Sung Han}",
year = "2008",
month = "2",
day = "1",
doi = "10.1159/000115781",
language = "English",
volume = "56",
pages = "146--151",
journal = "Neuropsychobiology",
issn = "0302-282X",
publisher = "S. Karger AG",
number = "2-3",

}

TY - JOUR

T1 - Association study of dopamine receptor D2TaqI A polymorphism and reward-related personality traits in healthy Korean young females

AU - Lee, So Hee

AU - Ham, Byung-Joo

AU - Cho, Youl Hee

AU - Lee, Seung Min

AU - Shim, Sung Han

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Background: Genetic factors make a significant contribution to the determination of human personality traits. We aimed to investigate the possible relationship between dopamine receptor D2 (DRD2) TaqI A polymorphism and the reward-related personality traits as measured by the Carver and White Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and Cloninger's Temperament and Character Inventory (TCI). Methods: The sample consisted of 267 female healthy Korean unrelated university students (age: 23.12 ± 3.22 years) and they filled out the BIS/BAS scales and the TCI. Genomic DNA was isolated from whole blood and genotyped with the fluorescence polarization detection method. The effect of the independent variables (DRD2 genotypes) on the dependent variables were analyzed by multivariate and subsequent univariate ANOVA. Results: We found significant associations between the A1 allele of the DRD2 TaqI A polymorphism and a high BAS-RR score (reward responsiveness). No significant association was observed between DRD2 polymorphisms and other factors of the BIS/BAS scales and TCI. Conclusion: These findings suggest the notion that DRD2 TaqI A polymorphism contributes to high reward sensitivity, which measures anticipation and positive response towards reward.

AB - Background: Genetic factors make a significant contribution to the determination of human personality traits. We aimed to investigate the possible relationship between dopamine receptor D2 (DRD2) TaqI A polymorphism and the reward-related personality traits as measured by the Carver and White Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales and Cloninger's Temperament and Character Inventory (TCI). Methods: The sample consisted of 267 female healthy Korean unrelated university students (age: 23.12 ± 3.22 years) and they filled out the BIS/BAS scales and the TCI. Genomic DNA was isolated from whole blood and genotyped with the fluorescence polarization detection method. The effect of the independent variables (DRD2 genotypes) on the dependent variables were analyzed by multivariate and subsequent univariate ANOVA. Results: We found significant associations between the A1 allele of the DRD2 TaqI A polymorphism and a high BAS-RR score (reward responsiveness). No significant association was observed between DRD2 polymorphisms and other factors of the BIS/BAS scales and TCI. Conclusion: These findings suggest the notion that DRD2 TaqI A polymorphism contributes to high reward sensitivity, which measures anticipation and positive response towards reward.

KW - Behavioral approach system

KW - Dopamine receptor DTaqI A polymorphism

KW - Personality traits

UR - http://www.scopus.com/inward/record.url?scp=40349086086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40349086086&partnerID=8YFLogxK

U2 - 10.1159/000115781

DO - 10.1159/000115781

M3 - Article

VL - 56

SP - 146

EP - 151

JO - Neuropsychobiology

JF - Neuropsychobiology

SN - 0302-282X

IS - 2-3

ER -