Association study of TP53 polymorphisms with lung cancer in a Korean population

Hae Yun Jung, Young Mi Whang, Jae Sook Sung, Hyoung Doo Shin, Byung Lae Park, Jun Suk Kim, Sang Won Shin, Hee Yun Seo, Jae Hong Seo, Yeul Hong Kim

Research output: Contribution to journalArticle

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Abstract

The tumor suppressor gene, TP53, is located on chromosome 17p13.1 and is critical for DNA repair, cell-cycle control, and apoptosis. TP53 also plays a crucial function in the tumorigenesis of lung cancer. Inactivation of TP53 via genetic alterations such as missense mutations is often associated with lung cancer. In this study, potential association of TP53 polymorphisms with the risk of lung cancer was examined in a Korean population. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed, and logistic regression analyses were conducted to characterize the association between TP53 polymorphisms and lung cancer risk. Through direct sequencing in 24 Korean individuals, 13 sequence variants were identified, and five of these polymorphisms were selected for a larger-scale genotyping (n = 595). Statistical analyses revealed that polymorphisms and haplotypes in the TP53 gene, including Arg72Pro, were not significantly associated with lung cancer in a Korean population.

Original languageEnglish
Pages (from-to)508-514
Number of pages7
JournalJournal of Human Genetics
Volume53
Issue number6
DOIs
Publication statusPublished - 2008 Jun 1

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Lung Neoplasms
Population
p53 Genes
Missense Mutation
Cell Cycle Checkpoints
Tumor Suppressor Genes
DNA Sequence Analysis
DNA Repair
Haplotypes
Carcinogenesis
Chromosomes
Logistic Models
Regression Analysis
Apoptosis

Keywords

  • Haplotypes
  • Korean population
  • Lung cancer
  • Single nucleotide polymorphisms
  • Tumor protein p53 (TP53)

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Association study of TP53 polymorphisms with lung cancer in a Korean population. / Jung, Hae Yun; Whang, Young Mi; Sung, Jae Sook; Shin, Hyoung Doo; Park, Byung Lae; Kim, Jun Suk; Shin, Sang Won; Seo, Hee Yun; Seo, Jae Hong; Kim, Yeul Hong.

In: Journal of Human Genetics, Vol. 53, No. 6, 01.06.2008, p. 508-514.

Research output: Contribution to journalArticle

Jung, Hae Yun ; Whang, Young Mi ; Sung, Jae Sook ; Shin, Hyoung Doo ; Park, Byung Lae ; Kim, Jun Suk ; Shin, Sang Won ; Seo, Hee Yun ; Seo, Jae Hong ; Kim, Yeul Hong. / Association study of TP53 polymorphisms with lung cancer in a Korean population. In: Journal of Human Genetics. 2008 ; Vol. 53, No. 6. pp. 508-514.
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AU - Park, Byung Lae

AU - Kim, Jun Suk

AU - Shin, Sang Won

AU - Seo, Hee Yun

AU - Seo, Jae Hong

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