Associations between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis, and between MIF gene polymorphisms and disease susceptibility: A meta-analysis

Sang Cheol Bae, Young Ho Lee

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6 Citations (Scopus)

Abstract

Aim To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. Design We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility. Patients Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included. Results MIF levels were significantly higher in the RA group than in the control group (standardised mean difference (95% CI) 0.923 (0.766 to 1.080), p<0.001). Stratification by ethnicity revealed significantly higher MIF levels in the RA group in Caucasian, Asian and Latin American populations. MIF levels were significantly higher in patients with RA, regardless of adjustment, sample size or data type evaluated. RA was identified to be significantly associated with the MIF-173 C allele (OR (95% CI) 1.271 (1.141 to 1.416), p<0.001), as well as with the -794CATT 7 allele (OR (95% CI) 1.229 (1.084 to 1.415), p=0.002) and the -794CATT 7 -MIF-173C haplotype RA (OR (95% CI) 1.433 (1.138 to 1.805), p=0.002). Conclusions Our meta-analyses revealed significantly higher circulating MIF levels in patients with RA, and found evidence of associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalPostgraduate Medical Journal
Volume94
Issue number1108
DOIs
Publication statusPublished - 2018 Feb 1

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Macrophage Migration-Inhibitory Factors
Disease Susceptibility
Meta-Analysis
Rheumatoid Arthritis
Genes
Alleles
Asian Americans
Sample Size
Haplotypes

Keywords

  • MIF level
  • polymorphism
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{0a4a0ebec9354e94a253bb80078dd106,
title = "Associations between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis, and between MIF gene polymorphisms and disease susceptibility: A meta-analysis",
abstract = "Aim To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. Design We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility. Patients Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included. Results MIF levels were significantly higher in the RA group than in the control group (standardised mean difference (95{\%} CI) 0.923 (0.766 to 1.080), p<0.001). Stratification by ethnicity revealed significantly higher MIF levels in the RA group in Caucasian, Asian and Latin American populations. MIF levels were significantly higher in patients with RA, regardless of adjustment, sample size or data type evaluated. RA was identified to be significantly associated with the MIF-173 C allele (OR (95{\%} CI) 1.271 (1.141 to 1.416), p<0.001), as well as with the -794CATT 7 allele (OR (95{\%} CI) 1.229 (1.084 to 1.415), p=0.002) and the -794CATT 7 -MIF-173C haplotype RA (OR (95{\%} CI) 1.433 (1.138 to 1.805), p=0.002). Conclusions Our meta-analyses revealed significantly higher circulating MIF levels in patients with RA, and found evidence of associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility.",
keywords = "MIF level, polymorphism, rheumatoid arthritis",
author = "Bae, {Sang Cheol} and Lee, {Young Ho}",
year = "2018",
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doi = "10.1136/postgradmedj-2017-134934",
language = "English",
volume = "94",
pages = "109--115",
journal = "Postgraduate Medical Journal",
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T1 - Associations between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis, and between MIF gene polymorphisms and disease susceptibility

T2 - A meta-analysis

AU - Bae, Sang Cheol

AU - Lee, Young Ho

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Aim To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. Design We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility. Patients Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included. Results MIF levels were significantly higher in the RA group than in the control group (standardised mean difference (95% CI) 0.923 (0.766 to 1.080), p<0.001). Stratification by ethnicity revealed significantly higher MIF levels in the RA group in Caucasian, Asian and Latin American populations. MIF levels were significantly higher in patients with RA, regardless of adjustment, sample size or data type evaluated. RA was identified to be significantly associated with the MIF-173 C allele (OR (95% CI) 1.271 (1.141 to 1.416), p<0.001), as well as with the -794CATT 7 allele (OR (95% CI) 1.229 (1.084 to 1.415), p=0.002) and the -794CATT 7 -MIF-173C haplotype RA (OR (95% CI) 1.433 (1.138 to 1.805), p=0.002). Conclusions Our meta-analyses revealed significantly higher circulating MIF levels in patients with RA, and found evidence of associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility.

AB - Aim To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. Design We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility. Patients Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included. Results MIF levels were significantly higher in the RA group than in the control group (standardised mean difference (95% CI) 0.923 (0.766 to 1.080), p<0.001). Stratification by ethnicity revealed significantly higher MIF levels in the RA group in Caucasian, Asian and Latin American populations. MIF levels were significantly higher in patients with RA, regardless of adjustment, sample size or data type evaluated. RA was identified to be significantly associated with the MIF-173 C allele (OR (95% CI) 1.271 (1.141 to 1.416), p<0.001), as well as with the -794CATT 7 allele (OR (95% CI) 1.229 (1.084 to 1.415), p=0.002) and the -794CATT 7 -MIF-173C haplotype RA (OR (95% CI) 1.433 (1.138 to 1.805), p=0.002). Conclusions Our meta-analyses revealed significantly higher circulating MIF levels in patients with RA, and found evidence of associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility.

KW - MIF level

KW - polymorphism

KW - rheumatoid arthritis

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U2 - 10.1136/postgradmedj-2017-134934

DO - 10.1136/postgradmedj-2017-134934

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JO - Postgraduate Medical Journal

JF - Postgraduate Medical Journal

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