TY - JOUR
T1 - Associations between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis, and between MIF gene polymorphisms and disease susceptibility
T2 - A meta-analysis
AU - Bae, Sang Cheol
AU - Lee, Young Ho
N1 - Funding Information:
Funding This study was supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958).
Publisher Copyright:
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Aim To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. Design We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility. Patients Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included. Results MIF levels were significantly higher in the RA group than in the control group (standardised mean difference (95% CI) 0.923 (0.766 to 1.080), p<0.001). Stratification by ethnicity revealed significantly higher MIF levels in the RA group in Caucasian, Asian and Latin American populations. MIF levels were significantly higher in patients with RA, regardless of adjustment, sample size or data type evaluated. RA was identified to be significantly associated with the MIF-173 C allele (OR (95% CI) 1.271 (1.141 to 1.416), p<0.001), as well as with the -794CATT 7 allele (OR (95% CI) 1.229 (1.084 to 1.415), p=0.002) and the -794CATT 7 -MIF-173C haplotype RA (OR (95% CI) 1.433 (1.138 to 1.805), p=0.002). Conclusions Our meta-analyses revealed significantly higher circulating MIF levels in patients with RA, and found evidence of associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility.
AB - Aim To systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility. Design We performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility. Patients Twelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included. Results MIF levels were significantly higher in the RA group than in the control group (standardised mean difference (95% CI) 0.923 (0.766 to 1.080), p<0.001). Stratification by ethnicity revealed significantly higher MIF levels in the RA group in Caucasian, Asian and Latin American populations. MIF levels were significantly higher in patients with RA, regardless of adjustment, sample size or data type evaluated. RA was identified to be significantly associated with the MIF-173 C allele (OR (95% CI) 1.271 (1.141 to 1.416), p<0.001), as well as with the -794CATT 7 allele (OR (95% CI) 1.229 (1.084 to 1.415), p=0.002) and the -794CATT 7 -MIF-173C haplotype RA (OR (95% CI) 1.433 (1.138 to 1.805), p=0.002). Conclusions Our meta-analyses revealed significantly higher circulating MIF levels in patients with RA, and found evidence of associations between the MIF-173 C/G and -794CATT 5-8 polymorphisms and RA susceptibility.
KW - MIF level
KW - polymorphism
KW - rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85042691705&partnerID=8YFLogxK
U2 - 10.1136/postgradmedj-2017-134934
DO - 10.1136/postgradmedj-2017-134934
M3 - Article
C2 - 28912189
AN - SCOPUS:85042691705
VL - 94
SP - 109
EP - 115
JO - Postgraduate Medical Journal
JF - Postgraduate Medical Journal
SN - 0032-5473
IS - 1108
ER -