Associations between eNOS polymorphisms and susceptibility to Behcet's disease

A meta-analysis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to Behcet's disease (BD). Methods A meta-analysis was conducted on the associations between the G894T and 4b/a polymorphisms of eNOS and BD using: (i) the allele contrast, (ii) the recessive model, (iii) the dominant model and (iv) the additive model. Results A total of eight studies, which included 841 cases and 866 controls, were included in the meta-analysis. Meta-analysis of the G894T polymorphism revealed no association with BD in all study subjects or in Turkish and Asian populations. However, one Tunisian study of the T allele showed a significant association with BD (OR = 0.707, 95% CI = 0.510-0.980, P = 0.038), but the OR of the T allele among Tunisians was lower, whereas it was higher in Europeans (OR = 2.129, 95% CI = 1.407-3.220, P = 0.0003). Meta-analysis showed no association between BD and the 4b/a polymorphism in all study subjects. Stratification by ethnicity indicated no significant association between the a allele of the 4b/a polymorphism and BD in Turkish and Asian populations. Conclusions This meta-analysis shows that the eNOS G894T and the 4b/a polymorphisms are not associated with BD in the Turkish and Asian populations. These data suggest that the G894T and the 4b/a polymorphisms may not confer susceptibility to BD in the Turkish and Asian populations.

Original languageEnglish
Pages (from-to)1266-1271
Number of pages6
JournalJournal of the European Academy of Dermatology and Venereology
Volume26
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Behcet Syndrome
Nitric Oxide Synthase Type III
Meta-Analysis
Alleles
Population

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

@article{51ab50c8b8a74c2b842c6acc8acb7be8,
title = "Associations between eNOS polymorphisms and susceptibility to Behcet's disease: A meta-analysis",
abstract = "Objective To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to Behcet's disease (BD). Methods A meta-analysis was conducted on the associations between the G894T and 4b/a polymorphisms of eNOS and BD using: (i) the allele contrast, (ii) the recessive model, (iii) the dominant model and (iv) the additive model. Results A total of eight studies, which included 841 cases and 866 controls, were included in the meta-analysis. Meta-analysis of the G894T polymorphism revealed no association with BD in all study subjects or in Turkish and Asian populations. However, one Tunisian study of the T allele showed a significant association with BD (OR = 0.707, 95{\%} CI = 0.510-0.980, P = 0.038), but the OR of the T allele among Tunisians was lower, whereas it was higher in Europeans (OR = 2.129, 95{\%} CI = 1.407-3.220, P = 0.0003). Meta-analysis showed no association between BD and the 4b/a polymorphism in all study subjects. Stratification by ethnicity indicated no significant association between the a allele of the 4b/a polymorphism and BD in Turkish and Asian populations. Conclusions This meta-analysis shows that the eNOS G894T and the 4b/a polymorphisms are not associated with BD in the Turkish and Asian populations. These data suggest that the G894T and the 4b/a polymorphisms may not confer susceptibility to BD in the Turkish and Asian populations.",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2012",
month = "10",
day = "1",
doi = "10.1111/j.1468-3083.2011.04280.x",
language = "English",
volume = "26",
pages = "1266--1271",
journal = "Journal of the European Academy of Dermatology and Venereology",
issn = "0926-9959",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Associations between eNOS polymorphisms and susceptibility to Behcet's disease

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Song, Gwan Gyu

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Objective To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to Behcet's disease (BD). Methods A meta-analysis was conducted on the associations between the G894T and 4b/a polymorphisms of eNOS and BD using: (i) the allele contrast, (ii) the recessive model, (iii) the dominant model and (iv) the additive model. Results A total of eight studies, which included 841 cases and 866 controls, were included in the meta-analysis. Meta-analysis of the G894T polymorphism revealed no association with BD in all study subjects or in Turkish and Asian populations. However, one Tunisian study of the T allele showed a significant association with BD (OR = 0.707, 95% CI = 0.510-0.980, P = 0.038), but the OR of the T allele among Tunisians was lower, whereas it was higher in Europeans (OR = 2.129, 95% CI = 1.407-3.220, P = 0.0003). Meta-analysis showed no association between BD and the 4b/a polymorphism in all study subjects. Stratification by ethnicity indicated no significant association between the a allele of the 4b/a polymorphism and BD in Turkish and Asian populations. Conclusions This meta-analysis shows that the eNOS G894T and the 4b/a polymorphisms are not associated with BD in the Turkish and Asian populations. These data suggest that the G894T and the 4b/a polymorphisms may not confer susceptibility to BD in the Turkish and Asian populations.

AB - Objective To determine whether endothelial nitric oxide synthase (eNOS) polymorphisms confer susceptibility to Behcet's disease (BD). Methods A meta-analysis was conducted on the associations between the G894T and 4b/a polymorphisms of eNOS and BD using: (i) the allele contrast, (ii) the recessive model, (iii) the dominant model and (iv) the additive model. Results A total of eight studies, which included 841 cases and 866 controls, were included in the meta-analysis. Meta-analysis of the G894T polymorphism revealed no association with BD in all study subjects or in Turkish and Asian populations. However, one Tunisian study of the T allele showed a significant association with BD (OR = 0.707, 95% CI = 0.510-0.980, P = 0.038), but the OR of the T allele among Tunisians was lower, whereas it was higher in Europeans (OR = 2.129, 95% CI = 1.407-3.220, P = 0.0003). Meta-analysis showed no association between BD and the 4b/a polymorphism in all study subjects. Stratification by ethnicity indicated no significant association between the a allele of the 4b/a polymorphism and BD in Turkish and Asian populations. Conclusions This meta-analysis shows that the eNOS G894T and the 4b/a polymorphisms are not associated with BD in the Turkish and Asian populations. These data suggest that the G894T and the 4b/a polymorphisms may not confer susceptibility to BD in the Turkish and Asian populations.

UR - http://www.scopus.com/inward/record.url?scp=84866242633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866242633&partnerID=8YFLogxK

U2 - 10.1111/j.1468-3083.2011.04280.x

DO - 10.1111/j.1468-3083.2011.04280.x

M3 - Article

VL - 26

SP - 1266

EP - 1271

JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

IS - 10

ER -