Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility

A meta-analysis

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility, using fixed and random effects models. Results: Six studies were included in this meta-analysis, which in total involved 4,594 AS patients and 3,971 controls, five European populations, and one Asian population. Meta-analysis identified a significant association between AS and the two alleles of the rs27044 polymorphism in all study subjects [odds ratio (OR) = 1.333, 95% confidence interval (CI) = 1.102-1.612, p = 0.003]. Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.281, 95% CI = 1.032-1.588, p = 0.024) and in Asians (OR = 1.554, 95% CI = 1.313-1.838, p = 2 × 10 -8), and meta-analysis of the rs30187 polymorphism showed the same pattern. Furthermore, analysis revealed significant associations between the two alleles of the rs17482078, rs10050860, and rs2287987 polymorphisms and the risk of developing AS in Europeans (OR = 0.726, 95% CI = 0.655-0.805, p < 1 × 10 -10; OR = 0.724, 95% CI = 0.665-0.787, p < 1 × 10 -10; OR = 0.708, 95% CI = 0.639-0.784, p < 1 × 10 -10, respectively). However, the single Asian study included showed no association between the rs17482078, rs30187, and rs2287987 polymorphisms and AS. Conclusions: This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans. However, further study of this association is required in other ethnic groups.

Original languageEnglish
Pages (from-to)999-1003
Number of pages5
JournalInflammation Research
Volume60
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

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Aminopeptidases
Ankylosing Spondylitis
Endoplasmic Reticulum
Meta-Analysis
Odds Ratio
Confidence Intervals
Alleles
Ethnic Groups
Population

Keywords

  • Ankylosing spondylitis
  • ERAP1
  • Meta-analysis
  • Polymorphism

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

@article{4c39f2dc9a0d4e4d9a5ca4f0c19640a8,
title = "Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: A meta-analysis",
abstract = "Objective: The aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility, using fixed and random effects models. Results: Six studies were included in this meta-analysis, which in total involved 4,594 AS patients and 3,971 controls, five European populations, and one Asian population. Meta-analysis identified a significant association between AS and the two alleles of the rs27044 polymorphism in all study subjects [odds ratio (OR) = 1.333, 95{\%} confidence interval (CI) = 1.102-1.612, p = 0.003]. Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.281, 95{\%} CI = 1.032-1.588, p = 0.024) and in Asians (OR = 1.554, 95{\%} CI = 1.313-1.838, p = 2 × 10 -8), and meta-analysis of the rs30187 polymorphism showed the same pattern. Furthermore, analysis revealed significant associations between the two alleles of the rs17482078, rs10050860, and rs2287987 polymorphisms and the risk of developing AS in Europeans (OR = 0.726, 95{\%} CI = 0.655-0.805, p < 1 × 10 -10; OR = 0.724, 95{\%} CI = 0.665-0.787, p < 1 × 10 -10; OR = 0.708, 95{\%} CI = 0.639-0.784, p < 1 × 10 -10, respectively). However, the single Asian study included showed no association between the rs17482078, rs30187, and rs2287987 polymorphisms and AS. Conclusions: This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans. However, further study of this association is required in other ethnic groups.",
keywords = "Ankylosing spondylitis, ERAP1, Meta-analysis, Polymorphism",
author = "Lee, {Young Ho} and Sungjae Choi and Ji, {Jong Dae} and Song, {Gwan Gyu}",
year = "2011",
month = "11",
day = "1",
doi = "10.1007/s00011-011-0374-x",
language = "English",
volume = "60",
pages = "999--1003",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
number = "11",

}

TY - JOUR

T1 - Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Objective: The aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility, using fixed and random effects models. Results: Six studies were included in this meta-analysis, which in total involved 4,594 AS patients and 3,971 controls, five European populations, and one Asian population. Meta-analysis identified a significant association between AS and the two alleles of the rs27044 polymorphism in all study subjects [odds ratio (OR) = 1.333, 95% confidence interval (CI) = 1.102-1.612, p = 0.003]. Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.281, 95% CI = 1.032-1.588, p = 0.024) and in Asians (OR = 1.554, 95% CI = 1.313-1.838, p = 2 × 10 -8), and meta-analysis of the rs30187 polymorphism showed the same pattern. Furthermore, analysis revealed significant associations between the two alleles of the rs17482078, rs10050860, and rs2287987 polymorphisms and the risk of developing AS in Europeans (OR = 0.726, 95% CI = 0.655-0.805, p < 1 × 10 -10; OR = 0.724, 95% CI = 0.665-0.787, p < 1 × 10 -10; OR = 0.708, 95% CI = 0.639-0.784, p < 1 × 10 -10, respectively). However, the single Asian study included showed no association between the rs17482078, rs30187, and rs2287987 polymorphisms and AS. Conclusions: This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans. However, further study of this association is required in other ethnic groups.

AB - Objective: The aim of this study was to determine whether five polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted five types of meta-analysis on the associations between the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 and AS susceptibility, using fixed and random effects models. Results: Six studies were included in this meta-analysis, which in total involved 4,594 AS patients and 3,971 controls, five European populations, and one Asian population. Meta-analysis identified a significant association between AS and the two alleles of the rs27044 polymorphism in all study subjects [odds ratio (OR) = 1.333, 95% confidence interval (CI) = 1.102-1.612, p = 0.003]. Stratification by ethnicity identified a significant association between this polymorphism and AS in Europeans (OR = 1.281, 95% CI = 1.032-1.588, p = 0.024) and in Asians (OR = 1.554, 95% CI = 1.313-1.838, p = 2 × 10 -8), and meta-analysis of the rs30187 polymorphism showed the same pattern. Furthermore, analysis revealed significant associations between the two alleles of the rs17482078, rs10050860, and rs2287987 polymorphisms and the risk of developing AS in Europeans (OR = 0.726, 95% CI = 0.655-0.805, p < 1 × 10 -10; OR = 0.724, 95% CI = 0.665-0.787, p < 1 × 10 -10; OR = 0.708, 95% CI = 0.639-0.784, p < 1 × 10 -10, respectively). However, the single Asian study included showed no association between the rs17482078, rs30187, and rs2287987 polymorphisms and AS. Conclusions: This meta-analysis shows that the rs27044, rs17482078, rs10050860, rs30187, and rs2287987 polymorphisms of ERAP1 are associated with the development of AS in Europeans. However, further study of this association is required in other ethnic groups.

KW - Ankylosing spondylitis

KW - ERAP1

KW - Meta-analysis

KW - Polymorphism

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U2 - 10.1007/s00011-011-0374-x

DO - 10.1007/s00011-011-0374-x

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