Associations between FCGR3A polymorphisms and susceptibility to rheumatoid arthritis

A metaanalysis

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective. To investigate whether the Fcγ receptor (FCGR) polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on the associations between FCGR polymorphisms and RA susceptibility as determined using (1) allele contrast, (2) recessive models, (3) dominant models, and (4) contrast of homozygotes, using fixed or random effects models. Results. A total of 10 separate comparisons were considered, which comprised 6 European and 4 Asian population samples. Metaanalysis of FCGR3A polymorphism revealed a significant association between the VV genotype and the risk of developing RA relative to the VF+FF genotype (OR 1.256, 95% CI 1.045-1.510, p = 0.015), with no evidence of between-study heterogeneity (p = 0.167). In subjects of European descent, a stronger association was observed between the VV genotype and RA than for the FF genotype (OR 1.374, 95% CI 1.101-1.714, p = 0.005). In Asians, no such association was found. Metaanalysis of the VV vs FF genotype revealed a significantly increased OR in Europeans (OR 1.399, 95% CI 1.107-1.769, p = 0.005), but not in Asians. No association was found between RA and the FCGR2A and FCGR3B polymorphisms in all subjects and in European and Asian populations, except for the NA22 vs NA11 of FCGR3B in Europeans. Conclusion. No relation was found between the FCGR2A polymorphism and susceptibility to RA in Europeans or Asians. The FCGR3A polymorphism was found to be associated with RA in Europeans but not in Asians. The FCGR3B polymorphism was associated with RA susceptibility in Europeans.

Original languageEnglish
Pages (from-to)2129-2135
Number of pages7
JournalJournal of Rheumatology
Volume35
Issue number11
DOIs
Publication statusPublished - 2008 Nov 1

Fingerprint

Rheumatoid Arthritis
Genotype
Fc Receptors
Homozygote
Population
Alleles

Keywords

  • Fcγ receptor
  • Metaanalysis
  • Polymorphism
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

@article{8ae737dec169436d9b661b2074960c81,
title = "Associations between FCGR3A polymorphisms and susceptibility to rheumatoid arthritis: A metaanalysis",
abstract = "Objective. To investigate whether the Fcγ receptor (FCGR) polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on the associations between FCGR polymorphisms and RA susceptibility as determined using (1) allele contrast, (2) recessive models, (3) dominant models, and (4) contrast of homozygotes, using fixed or random effects models. Results. A total of 10 separate comparisons were considered, which comprised 6 European and 4 Asian population samples. Metaanalysis of FCGR3A polymorphism revealed a significant association between the VV genotype and the risk of developing RA relative to the VF+FF genotype (OR 1.256, 95{\%} CI 1.045-1.510, p = 0.015), with no evidence of between-study heterogeneity (p = 0.167). In subjects of European descent, a stronger association was observed between the VV genotype and RA than for the FF genotype (OR 1.374, 95{\%} CI 1.101-1.714, p = 0.005). In Asians, no such association was found. Metaanalysis of the VV vs FF genotype revealed a significantly increased OR in Europeans (OR 1.399, 95{\%} CI 1.107-1.769, p = 0.005), but not in Asians. No association was found between RA and the FCGR2A and FCGR3B polymorphisms in all subjects and in European and Asian populations, except for the NA22 vs NA11 of FCGR3B in Europeans. Conclusion. No relation was found between the FCGR2A polymorphism and susceptibility to RA in Europeans or Asians. The FCGR3A polymorphism was found to be associated with RA in Europeans but not in Asians. The FCGR3B polymorphism was associated with RA susceptibility in Europeans.",
keywords = "Fcγ receptor, Metaanalysis, Polymorphism, Rheumatoid arthritis",
author = "Lee, {Young Ho} and Ji, {Jong Dae} and Song, {Gwan Gyu}",
year = "2008",
month = "11",
day = "1",
doi = "10.3899/jrheum.080186",
language = "English",
volume = "35",
pages = "2129--2135",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "11",

}

TY - JOUR

T1 - Associations between FCGR3A polymorphisms and susceptibility to rheumatoid arthritis

T2 - A metaanalysis

AU - Lee, Young Ho

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Objective. To investigate whether the Fcγ receptor (FCGR) polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on the associations between FCGR polymorphisms and RA susceptibility as determined using (1) allele contrast, (2) recessive models, (3) dominant models, and (4) contrast of homozygotes, using fixed or random effects models. Results. A total of 10 separate comparisons were considered, which comprised 6 European and 4 Asian population samples. Metaanalysis of FCGR3A polymorphism revealed a significant association between the VV genotype and the risk of developing RA relative to the VF+FF genotype (OR 1.256, 95% CI 1.045-1.510, p = 0.015), with no evidence of between-study heterogeneity (p = 0.167). In subjects of European descent, a stronger association was observed between the VV genotype and RA than for the FF genotype (OR 1.374, 95% CI 1.101-1.714, p = 0.005). In Asians, no such association was found. Metaanalysis of the VV vs FF genotype revealed a significantly increased OR in Europeans (OR 1.399, 95% CI 1.107-1.769, p = 0.005), but not in Asians. No association was found between RA and the FCGR2A and FCGR3B polymorphisms in all subjects and in European and Asian populations, except for the NA22 vs NA11 of FCGR3B in Europeans. Conclusion. No relation was found between the FCGR2A polymorphism and susceptibility to RA in Europeans or Asians. The FCGR3A polymorphism was found to be associated with RA in Europeans but not in Asians. The FCGR3B polymorphism was associated with RA susceptibility in Europeans.

AB - Objective. To investigate whether the Fcγ receptor (FCGR) polymorphism confers susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on the associations between FCGR polymorphisms and RA susceptibility as determined using (1) allele contrast, (2) recessive models, (3) dominant models, and (4) contrast of homozygotes, using fixed or random effects models. Results. A total of 10 separate comparisons were considered, which comprised 6 European and 4 Asian population samples. Metaanalysis of FCGR3A polymorphism revealed a significant association between the VV genotype and the risk of developing RA relative to the VF+FF genotype (OR 1.256, 95% CI 1.045-1.510, p = 0.015), with no evidence of between-study heterogeneity (p = 0.167). In subjects of European descent, a stronger association was observed between the VV genotype and RA than for the FF genotype (OR 1.374, 95% CI 1.101-1.714, p = 0.005). In Asians, no such association was found. Metaanalysis of the VV vs FF genotype revealed a significantly increased OR in Europeans (OR 1.399, 95% CI 1.107-1.769, p = 0.005), but not in Asians. No association was found between RA and the FCGR2A and FCGR3B polymorphisms in all subjects and in European and Asian populations, except for the NA22 vs NA11 of FCGR3B in Europeans. Conclusion. No relation was found between the FCGR2A polymorphism and susceptibility to RA in Europeans or Asians. The FCGR3A polymorphism was found to be associated with RA in Europeans but not in Asians. The FCGR3B polymorphism was associated with RA susceptibility in Europeans.

KW - Fcγ receptor

KW - Metaanalysis

KW - Polymorphism

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=56449129442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56449129442&partnerID=8YFLogxK

U2 - 10.3899/jrheum.080186

DO - 10.3899/jrheum.080186

M3 - Article

VL - 35

SP - 2129

EP - 2135

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 11

ER -