Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: A meta-analysis

Young Ho Lee, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)

    Abstract

    Aim: The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease. Materials & methods: We conducted a meta-analysis to evaluate the association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to TNF blockers. Results: The meta-analysis indicated that responsiveness to TNF blockers was associated with the FCGR3A V allele (odds ratio: 3.308; 95% CI: 1.053-10.39; p = 0.040) and the FCGR2A RR + RH genotype (odds ratio: 3.904; p = 0.027) in patients with a follow-up time of ≥6 months. Conclusion: FCGR3A V and FCGR2A R allele carriers show better responsiveness to anti-TNF-α therapy in patients with follow-up times ≥6 months.

    Original languageEnglish
    Pages (from-to)1465-1477
    Number of pages13
    JournalPharmacogenomics
    Volume17
    Issue number13
    DOIs
    Publication statusPublished - 2016 Aug

    Keywords

    • FCGR polymorphism
    • TNF blockers
    • responsiveness
    • spondyloarthropathy

    ASJC Scopus subject areas

    • Molecular Medicine
    • Genetics
    • Pharmacology

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