Associations between interleukin-10 polymorphisms and susceptibility to systemic lupus erythematosus

A meta-analysis

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19 Citations (Scopus)

Abstract

Objective: The study determined whether interleukin-10 (IL-10) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and SLE. Results: A total of 19 studies involving 2828 SLE patients and 4008 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism revealed an association between SLE and the IL-10-1082 G allele (odds ratio [OR]=1.158, 95% confidence interval [CI]=1.051-1.276, p=0.003). Stratification by ethnicity indicated an association between the IL-10-1082 G allele and SLE in Europeans (OR=1.160, 95% CI=1.039-1.296, p=0.008). Meta-analysis stratified by ethnicity produced an association between the IL-10-819 C allele and SLE in Asians (OR=1.308, 95% CI=1.030-1.619, p=0.027). Meta-analysis of the homozygous GCC/GCC haplotype failed to show a significant association with SLE in Europeans (OR=1.223, 95% CI=0.981-1.526, p=0.074). However, meta-analysis of the GCC haplotype revealed a significant association with RA in all study subjects (OR=1.402, 95% CI=1.001-1.964, p=0.049). Stratification by ethnicity indicated an association between the GCC haplotype and SLE in Europeans (OR=1.656, 95% CI=1.087-2.523, p=0.019), but not in Asians (OR=1.100, 95% CI=0.703-1.721, p=0.677). Meta-analysis of homozygous ATA/ATA haplotype failed to show a significant association with SLE in overall and European groups. However, meta-analysis of the ATA haplotype revealed a significant association with SLE in all study subjects (OR=1.516, 95% CI=1.039-2.213, p=0.031) and Asians (OR=2.580, 95% CI=2.086-3.192, p<1×10-9), but not in Europeans (OR=1.233, 95% CI=0.816-1.862, p=0.320). Conclusions: This meta-analysis suggests that the IL-10 polymorphisms confer susceptibility to SLE in Europeans and in Asians.

Original languageEnglish
Pages (from-to)364-370
Number of pages7
JournalHuman Immunology
Volume74
Issue number3
DOIs
Publication statusPublished - 2013 Mar 1

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Systemic Lupus Erythematosus
Interleukin-10
Meta-Analysis
Odds Ratio
Confidence Intervals
Haplotypes
Alleles

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

@article{63b6bd80ba334f1b8af0d0eb50ad672c,
title = "Associations between interleukin-10 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis",
abstract = "Objective: The study determined whether interleukin-10 (IL-10) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and SLE. Results: A total of 19 studies involving 2828 SLE patients and 4008 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism revealed an association between SLE and the IL-10-1082 G allele (odds ratio [OR]=1.158, 95{\%} confidence interval [CI]=1.051-1.276, p=0.003). Stratification by ethnicity indicated an association between the IL-10-1082 G allele and SLE in Europeans (OR=1.160, 95{\%} CI=1.039-1.296, p=0.008). Meta-analysis stratified by ethnicity produced an association between the IL-10-819 C allele and SLE in Asians (OR=1.308, 95{\%} CI=1.030-1.619, p=0.027). Meta-analysis of the homozygous GCC/GCC haplotype failed to show a significant association with SLE in Europeans (OR=1.223, 95{\%} CI=0.981-1.526, p=0.074). However, meta-analysis of the GCC haplotype revealed a significant association with RA in all study subjects (OR=1.402, 95{\%} CI=1.001-1.964, p=0.049). Stratification by ethnicity indicated an association between the GCC haplotype and SLE in Europeans (OR=1.656, 95{\%} CI=1.087-2.523, p=0.019), but not in Asians (OR=1.100, 95{\%} CI=0.703-1.721, p=0.677). Meta-analysis of homozygous ATA/ATA haplotype failed to show a significant association with SLE in overall and European groups. However, meta-analysis of the ATA haplotype revealed a significant association with SLE in all study subjects (OR=1.516, 95{\%} CI=1.039-2.213, p=0.031) and Asians (OR=2.580, 95{\%} CI=2.086-3.192, p<1×10-9), but not in Europeans (OR=1.233, 95{\%} CI=0.816-1.862, p=0.320). Conclusions: This meta-analysis suggests that the IL-10 polymorphisms confer susceptibility to SLE in Europeans and in Asians.",
author = "Song, {Gwan Gyu} and Sungjae Choi and Ji, {Jong Dae} and Lee, {Young Ho}",
year = "2013",
month = "3",
day = "1",
doi = "10.1016/j.humimm.2012.11.020",
language = "English",
volume = "74",
pages = "364--370",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Associations between interleukin-10 polymorphisms and susceptibility to systemic lupus erythematosus

T2 - A meta-analysis

AU - Song, Gwan Gyu

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Lee, Young Ho

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Objective: The study determined whether interleukin-10 (IL-10) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and SLE. Results: A total of 19 studies involving 2828 SLE patients and 4008 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism revealed an association between SLE and the IL-10-1082 G allele (odds ratio [OR]=1.158, 95% confidence interval [CI]=1.051-1.276, p=0.003). Stratification by ethnicity indicated an association between the IL-10-1082 G allele and SLE in Europeans (OR=1.160, 95% CI=1.039-1.296, p=0.008). Meta-analysis stratified by ethnicity produced an association between the IL-10-819 C allele and SLE in Asians (OR=1.308, 95% CI=1.030-1.619, p=0.027). Meta-analysis of the homozygous GCC/GCC haplotype failed to show a significant association with SLE in Europeans (OR=1.223, 95% CI=0.981-1.526, p=0.074). However, meta-analysis of the GCC haplotype revealed a significant association with RA in all study subjects (OR=1.402, 95% CI=1.001-1.964, p=0.049). Stratification by ethnicity indicated an association between the GCC haplotype and SLE in Europeans (OR=1.656, 95% CI=1.087-2.523, p=0.019), but not in Asians (OR=1.100, 95% CI=0.703-1.721, p=0.677). Meta-analysis of homozygous ATA/ATA haplotype failed to show a significant association with SLE in overall and European groups. However, meta-analysis of the ATA haplotype revealed a significant association with SLE in all study subjects (OR=1.516, 95% CI=1.039-2.213, p=0.031) and Asians (OR=2.580, 95% CI=2.086-3.192, p<1×10-9), but not in Europeans (OR=1.233, 95% CI=0.816-1.862, p=0.320). Conclusions: This meta-analysis suggests that the IL-10 polymorphisms confer susceptibility to SLE in Europeans and in Asians.

AB - Objective: The study determined whether interleukin-10 (IL-10) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and the haplotype of the IL-10-1082 G/A, -819 C/T, -592 C/A polymorphisms and SLE. Results: A total of 19 studies involving 2828 SLE patients and 4008 controls were considered in the meta-analysis. Meta-analysis of the IL-10-1082 G/A polymorphism revealed an association between SLE and the IL-10-1082 G allele (odds ratio [OR]=1.158, 95% confidence interval [CI]=1.051-1.276, p=0.003). Stratification by ethnicity indicated an association between the IL-10-1082 G allele and SLE in Europeans (OR=1.160, 95% CI=1.039-1.296, p=0.008). Meta-analysis stratified by ethnicity produced an association between the IL-10-819 C allele and SLE in Asians (OR=1.308, 95% CI=1.030-1.619, p=0.027). Meta-analysis of the homozygous GCC/GCC haplotype failed to show a significant association with SLE in Europeans (OR=1.223, 95% CI=0.981-1.526, p=0.074). However, meta-analysis of the GCC haplotype revealed a significant association with RA in all study subjects (OR=1.402, 95% CI=1.001-1.964, p=0.049). Stratification by ethnicity indicated an association between the GCC haplotype and SLE in Europeans (OR=1.656, 95% CI=1.087-2.523, p=0.019), but not in Asians (OR=1.100, 95% CI=0.703-1.721, p=0.677). Meta-analysis of homozygous ATA/ATA haplotype failed to show a significant association with SLE in overall and European groups. However, meta-analysis of the ATA haplotype revealed a significant association with SLE in all study subjects (OR=1.516, 95% CI=1.039-2.213, p=0.031) and Asians (OR=2.580, 95% CI=2.086-3.192, p<1×10-9), but not in Europeans (OR=1.233, 95% CI=0.816-1.862, p=0.320). Conclusions: This meta-analysis suggests that the IL-10 polymorphisms confer susceptibility to SLE in Europeans and in Asians.

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U2 - 10.1016/j.humimm.2012.11.020

DO - 10.1016/j.humimm.2012.11.020

M3 - Article

VL - 74

SP - 364

EP - 370

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 3

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