Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: A meta-analysis

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Abstract

Objective: The aim of this study was to determine whether three specific interleukin-10 (IL-10) polymorphisms confer susceptibility to psoriasis. Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -592 C/A polymorphisms and haplotypes of the IL-10-1082 G/A, -592 C/A, -819 C/T polymorphisms and psoriasis. Results: A total of eight studies involving 1,018 psoriasis patients and 1,186 controls were considered in the metaanalysis. No association was found between psoriasis and the IL-10-1082 G allele in all study subjects [odds ratio (OR) = 1.098, 95 % confidence interval (CI) = 0.923- 1.306, p = 0.291] or between this allele and psoriasis in Europeans (OR = 0.990, 95 % CI = 0.809-1.214, p = 0.925), but a significant association was found in Asians (OR = 1.785, 95 % CI = 1.144-2.76, p = 0.011). Three polymorphisms at the promoter region of IL-10 (-1082 G/A, -819 C/T, -592 C/A) are known to be in complete linkage disequilibrium, but no association was found between the haplotype and psoriasis. Conclusions: This meta-analysis shows that the IL-10- 1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalInflammation Research
Volume61
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1

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Psoriasis
Interleukin-10
Meta-Analysis
Odds Ratio
Confidence Intervals
Haplotypes
Alleles
Linkage Disequilibrium
Genetic Promoter Regions

Keywords

  • Interleukin-10
  • Meta-analysis
  • Polymorphism
  • Psoriasis

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

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title = "Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: A meta-analysis",
abstract = "Objective: The aim of this study was to determine whether three specific interleukin-10 (IL-10) polymorphisms confer susceptibility to psoriasis. Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -592 C/A polymorphisms and haplotypes of the IL-10-1082 G/A, -592 C/A, -819 C/T polymorphisms and psoriasis. Results: A total of eight studies involving 1,018 psoriasis patients and 1,186 controls were considered in the metaanalysis. No association was found between psoriasis and the IL-10-1082 G allele in all study subjects [odds ratio (OR) = 1.098, 95 {\%} confidence interval (CI) = 0.923- 1.306, p = 0.291] or between this allele and psoriasis in Europeans (OR = 0.990, 95 {\%} CI = 0.809-1.214, p = 0.925), but a significant association was found in Asians (OR = 1.785, 95 {\%} CI = 1.144-2.76, p = 0.011). Three polymorphisms at the promoter region of IL-10 (-1082 G/A, -819 C/T, -592 C/A) are known to be in complete linkage disequilibrium, but no association was found between the haplotype and psoriasis. Conclusions: This meta-analysis shows that the IL-10- 1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.",
keywords = "Interleukin-10, Meta-analysis, Polymorphism, Psoriasis",
author = "Lee, {Young Ho} and Sungjae Choi and Ji, {Jong Dae} and Song, {Gwan Gyu}",
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TY - JOUR

T1 - Associations between interleukin-10 polymorphisms and susceptibility to psoriasis

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Objective: The aim of this study was to determine whether three specific interleukin-10 (IL-10) polymorphisms confer susceptibility to psoriasis. Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -592 C/A polymorphisms and haplotypes of the IL-10-1082 G/A, -592 C/A, -819 C/T polymorphisms and psoriasis. Results: A total of eight studies involving 1,018 psoriasis patients and 1,186 controls were considered in the metaanalysis. No association was found between psoriasis and the IL-10-1082 G allele in all study subjects [odds ratio (OR) = 1.098, 95 % confidence interval (CI) = 0.923- 1.306, p = 0.291] or between this allele and psoriasis in Europeans (OR = 0.990, 95 % CI = 0.809-1.214, p = 0.925), but a significant association was found in Asians (OR = 1.785, 95 % CI = 1.144-2.76, p = 0.011). Three polymorphisms at the promoter region of IL-10 (-1082 G/A, -819 C/T, -592 C/A) are known to be in complete linkage disequilibrium, but no association was found between the haplotype and psoriasis. Conclusions: This meta-analysis shows that the IL-10- 1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.

AB - Objective: The aim of this study was to determine whether three specific interleukin-10 (IL-10) polymorphisms confer susceptibility to psoriasis. Methods: A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -592 C/A polymorphisms and haplotypes of the IL-10-1082 G/A, -592 C/A, -819 C/T polymorphisms and psoriasis. Results: A total of eight studies involving 1,018 psoriasis patients and 1,186 controls were considered in the metaanalysis. No association was found between psoriasis and the IL-10-1082 G allele in all study subjects [odds ratio (OR) = 1.098, 95 % confidence interval (CI) = 0.923- 1.306, p = 0.291] or between this allele and psoriasis in Europeans (OR = 0.990, 95 % CI = 0.809-1.214, p = 0.925), but a significant association was found in Asians (OR = 1.785, 95 % CI = 1.144-2.76, p = 0.011). Three polymorphisms at the promoter region of IL-10 (-1082 G/A, -819 C/T, -592 C/A) are known to be in complete linkage disequilibrium, but no association was found between the haplotype and psoriasis. Conclusions: This meta-analysis shows that the IL-10- 1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.

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KW - Meta-analysis

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