Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility

A meta-analysis

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether interleukin (IL)-23.R and IL-12B polymorphisms confer susceptibility to psoriasis. Methods: The authors conducted a meta-analysis on associations between the IL-23.R and IL-12B polymorphisms and psoriasis susceptibility. Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR].=.0.624, 95% confidence interval [CI].=.0.565-0.697, p.<.1.0.×.10-8; OR.=.0.804, 95% CI.=.0.743-0.869, p.=.3.0.×.10-7, respectively). Mea-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR.=.0.710, 95% CI.=.0.673-0.749, p.<.1.0.×. 10-8; OR.=.0.684, 95% CI.=.0.639-0.731, p.<.1.0.×.10 -8, respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans. Conclusions: This meta-analysis showed that the IL-23.R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.

Original languageEnglish
Pages (from-to)726-736
Number of pages11
JournalImmunological Investigations
Volume42
Issue number8
DOIs
Publication statusPublished - 2013 Oct 18

Fingerprint

Interleukin-12 Subunit p40
Interleukins
Psoriasis
Meta-Analysis
Interleukin-23
Odds Ratio
Confidence Intervals
Alleles

Keywords

  • Interleukin-12B
  • Interleukin-23.R
  • Meta-analysis
  • Polymorphism
  • Psoriasis

ASJC Scopus subject areas

  • Immunology

Cite this

@article{2c8fefb08fc4400b9bf25bd59f3e28e9,
title = "Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility: A meta-analysis",
abstract = "Objective: The aim of this study was to determine whether interleukin (IL)-23.R and IL-12B polymorphisms confer susceptibility to psoriasis. Methods: The authors conducted a meta-analysis on associations between the IL-23.R and IL-12B polymorphisms and psoriasis susceptibility. Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR].=.0.624, 95{\%} confidence interval [CI].=.0.565-0.697, p.<.1.0.×.10-8; OR.=.0.804, 95{\%} CI.=.0.743-0.869, p.=.3.0.×.10-7, respectively). Mea-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR.=.0.710, 95{\%} CI.=.0.673-0.749, p.<.1.0.×. 10-8; OR.=.0.684, 95{\%} CI.=.0.639-0.731, p.<.1.0.×.10 -8, respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans. Conclusions: This meta-analysis showed that the IL-23.R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.",
keywords = "Interleukin-12B, Interleukin-23.R, Meta-analysis, Polymorphism, Psoriasis",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2013",
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day = "18",
doi = "10.3109/08820139.2013.810241",
language = "English",
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T1 - Associations between interleukin-23R and interleukin-12B polymorphisms and psoriasis susceptibility

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Song, Gwan Gyu

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Objective: The aim of this study was to determine whether interleukin (IL)-23.R and IL-12B polymorphisms confer susceptibility to psoriasis. Methods: The authors conducted a meta-analysis on associations between the IL-23.R and IL-12B polymorphisms and psoriasis susceptibility. Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR].=.0.624, 95% confidence interval [CI].=.0.565-0.697, p.<.1.0.×.10-8; OR.=.0.804, 95% CI.=.0.743-0.869, p.=.3.0.×.10-7, respectively). Mea-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR.=.0.710, 95% CI.=.0.673-0.749, p.<.1.0.×. 10-8; OR.=.0.684, 95% CI.=.0.639-0.731, p.<.1.0.×.10 -8, respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans. Conclusions: This meta-analysis showed that the IL-23.R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.

AB - Objective: The aim of this study was to determine whether interleukin (IL)-23.R and IL-12B polymorphisms confer susceptibility to psoriasis. Methods: The authors conducted a meta-analysis on associations between the IL-23.R and IL-12B polymorphisms and psoriasis susceptibility. Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR].=.0.624, 95% confidence interval [CI].=.0.565-0.697, p.<.1.0.×.10-8; OR.=.0.804, 95% CI.=.0.743-0.869, p.=.3.0.×.10-7, respectively). Mea-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR.=.0.710, 95% CI.=.0.673-0.749, p.<.1.0.×. 10-8; OR.=.0.684, 95% CI.=.0.639-0.731, p.<.1.0.×.10 -8, respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans. Conclusions: This meta-analysis showed that the IL-23.R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.

KW - Interleukin-12B

KW - Interleukin-23.R

KW - Meta-analysis

KW - Polymorphism

KW - Psoriasis

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U2 - 10.3109/08820139.2013.810241

DO - 10.3109/08820139.2013.810241

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JO - Immunological Investigations

JF - Immunological Investigations

SN - 0882-0139

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ER -