Objective: The aim of this study was to determine whether interleukin (IL)-23.R and IL-12B polymorphisms confer susceptibility to psoriasis. Methods: The authors conducted a meta-analysis on associations between the IL-23.R and IL-12B polymorphisms and psoriasis susceptibility. Results: A total of 14 comparison studies were included in this meta-analysis. The meta-analysis identified a significant association between psoriasis and 2 alleles of the rs11209026 and rs7530511 polymorphisms in Europeans (odds ratio [OR].=.0.624, 95% confidence interval [CI].=.0.565-0.697, p.<.1.0.×.10-8; OR.=.0.804, 95% CI.=.0.743-0.869, p.=.3.0.×.10-7, respectively). Mea-analysis of IL-12B showed a significant association between the 2 alleles of the rs6887695 and rs3212227 polymorphisms and the risk of developing psoriasis (OR.=.0.710, 95% CI.=.0.673-0.749, p.<.1.0.×. 10-8; OR.=.0.684, 95% CI.=.0.639-0.731, p.<.1.0.×.10 -8, respectively). Stratification by ethnicity identified an association between the rs6887695 and rs3212227 polymorphisms and psoriasis in Europeans. Conclusions: This meta-analysis showed that the IL-23.R (rs11209026 and rs7530511) polymorphisms are associated with psoriasis risk in Europeans and that the IL-12B (rs6887695 and rs3212227) polymorphisms are associated with susceptibility to psoriasis in Europeans.
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