Abstract
Objective: The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-23R polymorphisms and AS susceptibility, using fixed and random effects models. Results: A total of 10 studies (14 separate comparisons) were included in this meta-analysis, which included European and Asian populations. Meta-analysis revealed a significant association between AS and the two alleles of rs11209032 polymorphism in all study subjects (OR = 1.182, 95% CI 1.120-1.249, P = 0.000). Stratification by ethnicity identified a significant association between this polymorphism and AS in the European (OR = 1.234, 95% CI 1.159-1.313, P = 0.000), but not in the Asian populations (OR = 1.030, 95% CI 0.921-1.152, P = 0.608). Meta-analyses of rs1004819, rs10489629, rs1343151, rs1495965, and rs2201841 polymorphisms showed the same pattern as that shown by rs11209032 meta-analysis. Meta-analysis also revealed a significant association between the two alleles of the rs11209026 and the rs11465804 polymorphisms and the risk of developing AS in Europeans. Interestingly, the rs7517847 polymorphism was found to be significantly associated with AS susceptibility in both Europeans and Asians. Conclusions: This meta-analysis shows that the IL-23R polymorphisms are associated with the development of AS in Europeans.
| Original language | English |
|---|---|
| Pages (from-to) | 143-149 |
| Number of pages | 7 |
| Journal | Inflammation Research |
| Volume | 61 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Feb 1 |
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Keywords
- Ankylosing spondylitis
- Interleukin-23R
- Meta-analysis
- Polymorphism
ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility : A meta-analysis. / Lee, Young Ho; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Inflammation Research, Vol. 61, No. 2, 01.02.2012, p. 143-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Objective: The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-23R polymorphisms and AS susceptibility, using fixed and random effects models. Results: A total of 10 studies (14 separate comparisons) were included in this meta-analysis, which included European and Asian populations. Meta-analysis revealed a significant association between AS and the two alleles of rs11209032 polymorphism in all study subjects (OR = 1.182, 95% CI 1.120-1.249, P = 0.000). Stratification by ethnicity identified a significant association between this polymorphism and AS in the European (OR = 1.234, 95% CI 1.159-1.313, P = 0.000), but not in the Asian populations (OR = 1.030, 95% CI 0.921-1.152, P = 0.608). Meta-analyses of rs1004819, rs10489629, rs1343151, rs1495965, and rs2201841 polymorphisms showed the same pattern as that shown by rs11209032 meta-analysis. Meta-analysis also revealed a significant association between the two alleles of the rs11209026 and the rs11465804 polymorphisms and the risk of developing AS in Europeans. Interestingly, the rs7517847 polymorphism was found to be significantly associated with AS susceptibility in both Europeans and Asians. Conclusions: This meta-analysis shows that the IL-23R polymorphisms are associated with the development of AS in Europeans.
AB - Objective: The aim of this study was to determine whether interleukin-23R (IL-23R) polymorphisms confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-23R polymorphisms and AS susceptibility, using fixed and random effects models. Results: A total of 10 studies (14 separate comparisons) were included in this meta-analysis, which included European and Asian populations. Meta-analysis revealed a significant association between AS and the two alleles of rs11209032 polymorphism in all study subjects (OR = 1.182, 95% CI 1.120-1.249, P = 0.000). Stratification by ethnicity identified a significant association between this polymorphism and AS in the European (OR = 1.234, 95% CI 1.159-1.313, P = 0.000), but not in the Asian populations (OR = 1.030, 95% CI 0.921-1.152, P = 0.608). Meta-analyses of rs1004819, rs10489629, rs1343151, rs1495965, and rs2201841 polymorphisms showed the same pattern as that shown by rs11209032 meta-analysis. Meta-analysis also revealed a significant association between the two alleles of the rs11209026 and the rs11465804 polymorphisms and the risk of developing AS in Europeans. Interestingly, the rs7517847 polymorphism was found to be significantly associated with AS susceptibility in both Europeans and Asians. Conclusions: This meta-analysis shows that the IL-23R polymorphisms are associated with the development of AS in Europeans.
KW - Ankylosing spondylitis
KW - Interleukin-23R
KW - Meta-analysis
KW - Polymorphism
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UR - http://www.scopus.com/inward/citedby.url?scp=84857624302&partnerID=8YFLogxK
U2 - 10.1007/s00011-011-0398-2
DO - 10.1007/s00011-011-0398-2
M3 - Article
VL - 61
SP - 143
EP - 149
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - 2
ER -