Assoziation zwischen Haupthistokompatibilitätskomplex-Klasse-I-Ketten-bezogenen Gen-A-Polymorphismen und der Suszeptibilität für M. Beçet: Eine Metaanalyse

Translated title of the contribution: Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet’s disease: A meta-analysis

Young Ho Lee, Gwan Gyu Song

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The purpose of this work was to investigate whether major histocompatibility complex class I chain-related gene A (MICA) polymorphisms are associated with susceptibility to Behcet’s disease (BD). Methods: A meta-analysis was conducted on the associations between the MICA-transmembrane (TM) A6 allele and the 009 allele of MICA exon 2–4 (MICA*009) and BD with or without HLA-B51 overall and in each ethnic group. Results: Fifteen comparison studies were included in this meta-analysis. The meta-analysis revealed a significant association between the MICA-TM A6 allele and BD in European, Asian, and Arab populations [odds ratio (OR) 1.436, 95 % confidence interval (CI) 1.111–1.857, p = 0.006; OR 1.999, 95 % CI 1.551–2.575, p = 8.0 × 10−8; OR 1.333, 95 % CI 1.058–2.300, p = 0.025, respectively,]). Stratification by HLA-B51 showed an association between the MICA-TM A6 allele and BD with HLA-B51 in the overall group and in the European population. Meta-analysis showed a significant association between the MICA*009 allele and BD in the overall group (OR 3.948, 95 % CI 2.680–5.815, p < 1.0 × 10−8) and in the European population (OR 3.392, 95 % CI 2.118–5.433, p = 5.6 × 10−6). A significant association was found between the MICA*009 allele and B51-positive BD. Conclusion: This meta-analysis shows that the MICA-TM A6 allele and the MICA*009 allele are associated with BD susceptibility in various ethnic populations, and that MICA alleles are in strong linkage disequilibrium with HLA-B51 in BD.

Translated title of the contributionAssociations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet’s disease: A meta-analysis
Original languageGerman
Pages (from-to)714-721
Number of pages8
JournalZeitschrift fur Rheumatologie
Volume74
Issue number8
DOIs
Publication statusPublished - 2015 Oct 1

Keywords

  • Behcet syndrome
  • Histocompatibility antigens class I
  • HLA-B51 antigen
  • MICA
  • Polymorphism, genetic

ASJC Scopus subject areas

  • Rheumatology

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