Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus

A meta-analysis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). Materials and methods: The authors conducted metaanalyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2. Results: A total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 % confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 % CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 % CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians. Conclusions: This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.

Original languageEnglish
Pages (from-to)949-954
Number of pages6
JournalInflammation Research
Volume61
Issue number9
DOIs
Publication statusPublished - 2012 Sep 1

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TYK2 Kinase
Systemic Lupus Erythematosus
Meta-Analysis
Odds Ratio
Confidence Intervals
Alleles
Protein-Serine-Threonine Kinases
Population

Keywords

  • Meta-analysis
  • Phox homology domain containing serine/threonine kinase
  • Polymorphisms
  • Systemic lupus erythematosus
  • Tyrosine kinase 2

ASJC Scopus subject areas

  • Pharmacology
  • Immunology

Cite this

@article{c0677bd67d054d63b2212b04abf82b44,
title = "Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: A meta-analysis",
abstract = "Objective: The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). Materials and methods: The authors conducted metaanalyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2. Results: A total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 {\%} confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 {\%} CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 {\%} CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians. Conclusions: This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.",
keywords = "Meta-analysis, Phox homology domain containing serine/threonine kinase, Polymorphisms, Systemic lupus erythematosus, Tyrosine kinase 2",
author = "Lee, {Young Ho} and Sungjae Choi and Ji, {Jong Dae} and Song, {Gwan Gyu}",
year = "2012",
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doi = "10.1007/s00011-012-0486-y",
language = "English",
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pages = "949--954",
journal = "Inflammation Research",
issn = "1023-3830",
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TY - JOUR

T1 - Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Objective: The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). Materials and methods: The authors conducted metaanalyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2. Results: A total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 % confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 % CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 % CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians. Conclusions: This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.

AB - Objective: The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). Materials and methods: The authors conducted metaanalyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2. Results: A total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 % confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 % CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 % CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians. Conclusions: This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.

KW - Meta-analysis

KW - Phox homology domain containing serine/threonine kinase

KW - Polymorphisms

KW - Systemic lupus erythematosus

KW - Tyrosine kinase 2

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DO - 10.1007/s00011-012-0486-y

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SN - 1023-3830

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