Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: A meta-analysis

Young Ho Lee, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

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    19 Citations (Scopus)

    Abstract

    Objective: The aim of this study was to determine whether phox homology domain containing serine/threonine kinase (PXK) and tyrosine kinase 2 (TYK2) confer susceptibility to systemic lupus erythematosus (SLE). Materials and methods: The authors conducted metaanalyses on associations between SLE susceptibility and the rs6445975 polymorphism of PXK and the rs2304256, rs12720270, rs280519, and rs1272036 polymorphisms of TYK2. Results: A total of 13 separate comparisons studies were included in this meta-analysis. Meta-analysis identified an association between SLE and the 2 allele of the rs6445975 polymorphism in the overall population [odds ratio (OR) = 1.151, 95 % confidence interval (CI) = 1.086-1.291, P = 1.8E-06]. Stratification by ethnicity identified a significant association between this polymorphism and SLE in Europeans (OR = 1.198, 95 % CI = 1.118-1.285, P = 3.4E-07), but not in Asians. Meta-analysis identified a significant negative association between SLE and the 2 allele of the rs2304256 polymorphism in the overall population (OR = 0.808, 95 % CI = 0.659-0.990, P = 0.040), and a significant negative association was found in Europeans, but not in Asians. Conclusions: This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.

    Original languageEnglish
    Pages (from-to)949-954
    Number of pages6
    JournalInflammation Research
    Volume61
    Issue number9
    DOIs
    Publication statusPublished - 2012 Sep

    Keywords

    • Meta-analysis
    • Phox homology domain containing serine/threonine kinase
    • Polymorphisms
    • Systemic lupus erythematosus
    • Tyrosine kinase 2

    ASJC Scopus subject areas

    • Immunology
    • Pharmacology

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