Associations between Renal Hyperfiltration and Serum Alkaline Phosphatase

Se Won Oh, Kum Hyun Han, Sang Youb Han

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Renal hyperfiltration, which is associated with renal injury, occurs in diabetic or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary excretion of ALP has been demonstrated in patients who have hyperfiltration and tubular damage. However, little was investigated about the association between hyperfiltration and serum ALP level. A retrospective observational study of the 21,308 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008-2011) was performed. Renal hyperfiltration was defined as exceeding the age- and sex-specific 97.5th percentile. We divided participants into 4 groups according to their estimated glomerular filtration rate (eGFR): > 120, 90-119, 60-89, and <60 mL/min/1.73 m2 . The participants with eGFR >120 mL/min/ 1.73 m2 showed the highest risk for MS, in the highest ALP quartiles (3.848, 95% CI, 1.876-7.892), compared to the lowest quartile. Similarly, the highest risk for DM, in the highest ALP quartiles, was observed in participants with eGFR >120 ml/min/1.73 m2 (2.166, 95% CI, 1.084-4.329). ALP quartiles were significantly associated with albuminuria in participants with eGFR -≥ 60 ml/min/1.73m2 . The highest ALP quartile had a 1.631-fold risk elevation for albuminuria with adjustment of age and sex. (95% CI, 1.158-2.297, P = 0.005). After adjustment, the highest ALP quartile had a 1.624-fold risk elevation, for renal hyperfiltration (95% CI, 1.204- 2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P <0.05). The relationship between serum ALP and metabolic disorders is stronger in participants with an upper-normal range of eGFR. Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population.

Original languageEnglish
Article numbere122921
JournalPLoS One
Volume10
Issue number4
DOIs
Publication statusPublished - 2015 Apr 8
Externally publishedYes

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Alkaline Phosphatase
alkaline phosphatase
kidneys
Kidney
Serum
glomerular filtration rate
Glomerular Filtration Rate
Social Adjustment
Albuminuria
metabolic syndrome
National Health and Nutrition Examination Survey
gender
Nutrition Surveys
metabolic diseases
observational studies
Korea
Nutrition
Medical problems
Leukocyte Count
leukocyte count

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Associations between Renal Hyperfiltration and Serum Alkaline Phosphatase. / Oh, Se Won; Han, Kum Hyun; Han, Sang Youb.

In: PLoS One, Vol. 10, No. 4, e122921, 08.04.2015.

Research output: Contribution to journalArticle

Oh, Se Won ; Han, Kum Hyun ; Han, Sang Youb. / Associations between Renal Hyperfiltration and Serum Alkaline Phosphatase. In: PLoS One. 2015 ; Vol. 10, No. 4.
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abstract = "Renal hyperfiltration, which is associated with renal injury, occurs in diabetic or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary excretion of ALP has been demonstrated in patients who have hyperfiltration and tubular damage. However, little was investigated about the association between hyperfiltration and serum ALP level. A retrospective observational study of the 21,308 adults in the Korea National Health and Nutrition Examination Survey IV-V databases (2008-2011) was performed. Renal hyperfiltration was defined as exceeding the age- and sex-specific 97.5th percentile. We divided participants into 4 groups according to their estimated glomerular filtration rate (eGFR): > 120, 90-119, 60-89, and <60 mL/min/1.73 m2 . The participants with eGFR >120 mL/min/ 1.73 m2 showed the highest risk for MS, in the highest ALP quartiles (3.848, 95{\%} CI, 1.876-7.892), compared to the lowest quartile. Similarly, the highest risk for DM, in the highest ALP quartiles, was observed in participants with eGFR >120 ml/min/1.73 m2 (2.166, 95{\%} CI, 1.084-4.329). ALP quartiles were significantly associated with albuminuria in participants with eGFR -≥ 60 ml/min/1.73m2 . The highest ALP quartile had a 1.631-fold risk elevation for albuminuria with adjustment of age and sex. (95{\%} CI, 1.158-2.297, P = 0.005). After adjustment, the highest ALP quartile had a 1.624-fold risk elevation, for renal hyperfiltration (95{\%} CI, 1.204- 2.192, P = 0.002). In addition, hyperfiltration was significantly associated with hemoglobin, triglyceride, white blood cell count, DM, smoking, and alcohol consumption (P <0.05). The relationship between serum ALP and metabolic disorders is stronger in participants with an upper-normal range of eGFR. Higher ALP levels are significantly associated with renal hyperfiltration in Korean general population.",
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