Abstract
Objective The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). Methods A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE. Results A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846-0.936, p=5.5×10-7). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848-0.901, p=3.0×10-9). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641-0.832, p=1.4×10-6). Conclusions Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
| Original language | English |
|---|---|
| Pages (from-to) | 1177-1183 |
| Number of pages | 7 |
| Journal | Lupus |
| Volume | 24 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
Fingerprint
Keywords
- CD40
- polymorphism meta-analysis
- Rheumatoid arthritis
- systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
Cite this
Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus : A meta-analysis. / Lee, Young Ho; Bae, S. C.; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.
In: Lupus, Vol. 24, No. 11, 01.01.2015, p. 1177-1183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Bae, S. C.
AU - Choi, Sungjae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Objective The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). Methods A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE. Results A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846-0.936, p=5.5×10-7). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848-0.901, p=3.0×10-9). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641-0.832, p=1.4×10-6). Conclusions Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
AB - Objective The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). Methods A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE. Results A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846-0.936, p=5.5×10-7). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848-0.901, p=3.0×10-9). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641-0.832, p=1.4×10-6). Conclusions Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
KW - CD40
KW - polymorphism meta-analysis
KW - Rheumatoid arthritis
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84941198406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941198406&partnerID=8YFLogxK
U2 - 10.1177/0961203315583543
DO - 10.1177/0961203315583543
M3 - Article
C2 - 25908480
AN - SCOPUS:84941198406
VL - 24
SP - 1177
EP - 1183
JO - Lupus
JF - Lupus
SN - 0961-2033
IS - 11
ER -