Associations between the major histocompatibility complex class i chain-related gene A transmembrane (MICA-TM) polymorphism and susceptibility to psoriasis and psoriatic arthritis

A meta-analysis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The aim of this study was to assess whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with the susceptibility to psoriasis and psoriatic arthritis (PsA). A meta-analysis was conducted to establish the association between the MICA-TM A9 allele and psoriasis and PsA in the general population and each ethnic group. Ten studies (6 psoriasis, 4 PsA) involving 2,002 cases and 1,933 controls were included in this meta-analysis. The Asian controls showed the lowest A9 allele prevalence (16.6 %), whereas the European controls had the highest allele prevalence (33.3 %). Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population, which included the psoriasis and PsA cases (OR 1.703; 95 % CI 1.301-2.229; p = 1.0 × 10 -5). We further divided the entire study population into the psoriasis and PsA groups. Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population (OR 1.427, 95 % CI 1.021-1.994; p = 0.037) and Asians (OR 1.264; 95 % CI 1.014-1.576; p = 0.037). A significant association was found between the MICA-TM A9 allele and PsA (OR 2.227; 95 % CI 1.462-3.393; p = 1.9 × 10-5) and Europeans (OR 2.039; 95 % CI 1.285-3.235; p = 0.002). This meta-analysis showed that the MICA-TM A9 allele is associated with psoriasis susceptibility in Asian populations and that the MICA-TM A9 allele is associated with a PsA risk in Europeans.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalRheumatology International
Volume34
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Psoriatic Arthritis
Major Histocompatibility Complex
Psoriasis
Meta-Analysis
Alleles
Genes
Population
Ethnic Groups

Keywords

  • Meta-analysis
  • MICA
  • Polymorphism
  • Psoriasis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

@article{d0a28c9933dc42fa83b196a3f14e1327,
title = "Associations between the major histocompatibility complex class i chain-related gene A transmembrane (MICA-TM) polymorphism and susceptibility to psoriasis and psoriatic arthritis: A meta-analysis",
abstract = "The aim of this study was to assess whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with the susceptibility to psoriasis and psoriatic arthritis (PsA). A meta-analysis was conducted to establish the association between the MICA-TM A9 allele and psoriasis and PsA in the general population and each ethnic group. Ten studies (6 psoriasis, 4 PsA) involving 2,002 cases and 1,933 controls were included in this meta-analysis. The Asian controls showed the lowest A9 allele prevalence (16.6 {\%}), whereas the European controls had the highest allele prevalence (33.3 {\%}). Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population, which included the psoriasis and PsA cases (OR 1.703; 95 {\%} CI 1.301-2.229; p = 1.0 × 10 -5). We further divided the entire study population into the psoriasis and PsA groups. Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population (OR 1.427, 95 {\%} CI 1.021-1.994; p = 0.037) and Asians (OR 1.264; 95 {\%} CI 1.014-1.576; p = 0.037). A significant association was found between the MICA-TM A9 allele and PsA (OR 2.227; 95 {\%} CI 1.462-3.393; p = 1.9 × 10-5) and Europeans (OR 2.039; 95 {\%} CI 1.285-3.235; p = 0.002). This meta-analysis showed that the MICA-TM A9 allele is associated with psoriasis susceptibility in Asian populations and that the MICA-TM A9 allele is associated with a PsA risk in Europeans.",
keywords = "Meta-analysis, MICA, Polymorphism, Psoriasis",
author = "Song, {Gwan Gyu} and Kim, {Jae Hoon} and Lee, {Young Ho}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s00296-013-2849-2",
language = "English",
volume = "34",
pages = "117--123",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Associations between the major histocompatibility complex class i chain-related gene A transmembrane (MICA-TM) polymorphism and susceptibility to psoriasis and psoriatic arthritis

T2 - A meta-analysis

AU - Song, Gwan Gyu

AU - Kim, Jae Hoon

AU - Lee, Young Ho

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The aim of this study was to assess whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with the susceptibility to psoriasis and psoriatic arthritis (PsA). A meta-analysis was conducted to establish the association between the MICA-TM A9 allele and psoriasis and PsA in the general population and each ethnic group. Ten studies (6 psoriasis, 4 PsA) involving 2,002 cases and 1,933 controls were included in this meta-analysis. The Asian controls showed the lowest A9 allele prevalence (16.6 %), whereas the European controls had the highest allele prevalence (33.3 %). Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population, which included the psoriasis and PsA cases (OR 1.703; 95 % CI 1.301-2.229; p = 1.0 × 10 -5). We further divided the entire study population into the psoriasis and PsA groups. Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population (OR 1.427, 95 % CI 1.021-1.994; p = 0.037) and Asians (OR 1.264; 95 % CI 1.014-1.576; p = 0.037). A significant association was found between the MICA-TM A9 allele and PsA (OR 2.227; 95 % CI 1.462-3.393; p = 1.9 × 10-5) and Europeans (OR 2.039; 95 % CI 1.285-3.235; p = 0.002). This meta-analysis showed that the MICA-TM A9 allele is associated with psoriasis susceptibility in Asian populations and that the MICA-TM A9 allele is associated with a PsA risk in Europeans.

AB - The aim of this study was to assess whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with the susceptibility to psoriasis and psoriatic arthritis (PsA). A meta-analysis was conducted to establish the association between the MICA-TM A9 allele and psoriasis and PsA in the general population and each ethnic group. Ten studies (6 psoriasis, 4 PsA) involving 2,002 cases and 1,933 controls were included in this meta-analysis. The Asian controls showed the lowest A9 allele prevalence (16.6 %), whereas the European controls had the highest allele prevalence (33.3 %). Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population, which included the psoriasis and PsA cases (OR 1.703; 95 % CI 1.301-2.229; p = 1.0 × 10 -5). We further divided the entire study population into the psoriasis and PsA groups. Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population (OR 1.427, 95 % CI 1.021-1.994; p = 0.037) and Asians (OR 1.264; 95 % CI 1.014-1.576; p = 0.037). A significant association was found between the MICA-TM A9 allele and PsA (OR 2.227; 95 % CI 1.462-3.393; p = 1.9 × 10-5) and Europeans (OR 2.039; 95 % CI 1.285-3.235; p = 0.002). This meta-analysis showed that the MICA-TM A9 allele is associated with psoriasis susceptibility in Asian populations and that the MICA-TM A9 allele is associated with a PsA risk in Europeans.

KW - Meta-analysis

KW - MICA

KW - Polymorphism

KW - Psoriasis

UR - http://www.scopus.com/inward/record.url?scp=84892592544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892592544&partnerID=8YFLogxK

U2 - 10.1007/s00296-013-2849-2

DO - 10.1007/s00296-013-2849-2

M3 - Article

VL - 34

SP - 117

EP - 123

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 1

ER -