TY - JOUR
T1 - Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Bae, Sang Cheol
AU - Choi, Sung Jae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
N1 - Funding Information:
Acknowledgments This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/6
Y1 - 2012/6
N2 - Objective: The aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations. Methods: The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and RA susceptibility. Result: A total of ten comparative studies were included in this meta-analysis, which showed an association between the two allele of rs6920220 and RA in all study subjects [odds ratio (OR) 1.216, 95% confidence interval (CI) 1.166-1.269, p<1.0 × 10 -9]. The two allele of rs6920220 was also significantly associated with RA in Europeans only (OR 1.227, 95% CI 1.175-1.282, p<1.0 × 10 -9). Meta-analysis revealed no association between the two allele of the rs10499194 polymorphism and RA in Europeans, but a significant association was found in Asians (OR 1.254, 95% CI 1.101-1.429, p = 6.7 × 10 -4). Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214-2.331, p = 1.9 × 10 -6). Conclusions: Thismeta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
AB - Objective: The aim of this study was to determine whether tumor necrosis factor alpha inducible protein 3 (TNFAIP3) polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations. Methods: The authors conducted meta-analyses on associations between the TNFAIP3 polymorphisms and RA susceptibility. Result: A total of ten comparative studies were included in this meta-analysis, which showed an association between the two allele of rs6920220 and RA in all study subjects [odds ratio (OR) 1.216, 95% confidence interval (CI) 1.166-1.269, p<1.0 × 10 -9]. The two allele of rs6920220 was also significantly associated with RA in Europeans only (OR 1.227, 95% CI 1.175-1.282, p<1.0 × 10 -9). Meta-analysis revealed no association between the two allele of the rs10499194 polymorphism and RA in Europeans, but a significant association was found in Asians (OR 1.254, 95% CI 1.101-1.429, p = 6.7 × 10 -4). Furthermore, an association was found between the two allele of rs2230926 and RA in all study subjects (OR 1.390, 95% CI 1.214-2.331, p = 1.9 × 10 -6). Conclusions: Thismeta-analysis confirms that the TNFAIP3 polymorphisms are associated with RA susceptibility in different ethnic groups, namely, in Europeans for rs6920220 and in Asians for rs10499194.
KW - Meta-analysis
KW - Polymorphism
KW - Rheumatoid arthritis
KW - Tumor necrosis factor alpha inducible protein 3
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U2 - 10.1007/s00011-012-0455-5
DO - 10.1007/s00011-012-0455-5
M3 - Article
C2 - 22402800
AN - SCOPUS:84865137693
VL - 61
SP - 635
EP - 641
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
IS - 6
ER -