TY - JOUR
T1 - Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Song, Gwan Gyu
N1 - Funding Information:
This study was supported by a Grant from the Korean University Medical Center.
PY - 2012/10
Y1 - 2012/10
N2 - Objective: The aim of this study was to determine whether tumor necrosis factor superfamily 4 (TNFSF4) and TNF receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: The authors conducted meta-analyses on associations between polymorphisms of the TNFSF4 (rs2205960, rs1234315, rs10489265) and TRAF1-C5 (rs10818488, rs3761847) genes and SLE susceptibility, using fixed and random effects models. Results: A total of 21 comparative studies were included in this meta-analysis; meta-analysis showed an association between the minor allele of rs2205960 of TNFSF4 and SLE in all study subjects (odds ratio [OR]=1.356, 95% confidence interval [CI]=1.275-1.442, p<1.0×10-9). Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10-9; OR=1.463, 95% CI=1.208-1.771, p=9.7×10-5). The minor allele of rs10818488 of TRAF1-C5 was found to be significantly associated with SLE in Europeans (OR=1.210, 95% CI=1.115-1.313, p=5.0×10-6). The association p-values remained significant after multiple corrections. Conclusions: This meta-analysis confirms that TNFSF4 polymorphisms are associated with susceptibility to SLE in Asians and Europeans. An association was found between the rs10818488 polymorphism of TRAF1-C5 and susceptibility to SLE in Europeans.
AB - Objective: The aim of this study was to determine whether tumor necrosis factor superfamily 4 (TNFSF4) and TNF receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE). Methods: The authors conducted meta-analyses on associations between polymorphisms of the TNFSF4 (rs2205960, rs1234315, rs10489265) and TRAF1-C5 (rs10818488, rs3761847) genes and SLE susceptibility, using fixed and random effects models. Results: A total of 21 comparative studies were included in this meta-analysis; meta-analysis showed an association between the minor allele of rs2205960 of TNFSF4 and SLE in all study subjects (odds ratio [OR]=1.356, 95% confidence interval [CI]=1.275-1.442, p<1.0×10-9). Meta-analysis revealed an association between the minor alleles of rs1234315 and rs10489265 of TNFSF4 and SLE in Asians (OR=1.366, 95% CI=1.295-1.440, p<1.0×10-9; OR=1.463, 95% CI=1.208-1.771, p=9.7×10-5). The minor allele of rs10818488 of TRAF1-C5 was found to be significantly associated with SLE in Europeans (OR=1.210, 95% CI=1.115-1.313, p=5.0×10-6). The association p-values remained significant after multiple corrections. Conclusions: This meta-analysis confirms that TNFSF4 polymorphisms are associated with susceptibility to SLE in Asians and Europeans. An association was found between the rs10818488 polymorphism of TRAF1-C5 and susceptibility to SLE in Europeans.
UR - http://www.scopus.com/inward/record.url?scp=84866356404&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2012.07.044
DO - 10.1016/j.humimm.2012.07.044
M3 - Article
C2 - 22820624
AN - SCOPUS:84866356404
SN - 0198-8859
VL - 73
SP - 1050
EP - 1054
JO - Human Immunology
JF - Human Immunology
IS - 10
ER -