TY - JOUR
T1 - Associations between TRAF1-C5 gene polymorphisms and rheumatoid arthritis
T2 - A meta-analysis
AU - Song, Gwan Gyu
AU - Bae, Sang Cheol
AU - Kim, Jae Hoon
AU - Lee, Young Ho
N1 - Funding Information:
This study was supported by a grant from the Korean Healthcare Technology R&D Project, Korean Ministry of Health and Welfare (A102065).
PY - 2014
Y1 - 2014
N2 - Objective: The aim of this study is to determine whether tumor necrosis factor receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in different populations. Methods: We conducted a meta-analysis of associations between the TRAF1-C5 polymorphisms and RA susceptibility. Results: A total of 24 comparative studies were included in this meta-analysis, including 22,682 patients with RA and 23,493 controls. The meta-analysis showed an association between the second allele of rs10818488 and RA in Europeans, but not in Asians (OR 1.229, 95% CI 1.094-1.381, p = 0.001; OR 1.060, 95% CI 0.930-1.335, p = 0.092). The meta-analysis also indicated an association between the second allele of rs3761847 and RA in Europeans, but not in Asians (OR 1.156, 95% CI 1.006-1.327, p = 0.041; OR 1.049, 95% CI 0.952-1.156, p = 0.333). The meta-analysis revealed an association between the second allele of the rs2900180 and rs10760130 polymorphisms and RA risk in Europeans (OR 1.224, 95% CI 1.065-1.405, p = 0.004; OR 1.072, 95% CI 1.002-1.147, p = 0.042). Conclusions: This meta-analysis confirms that the TRAF1-C5 rs10818488, rs3761847, rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans.
AB - Objective: The aim of this study is to determine whether tumor necrosis factor receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in different populations. Methods: We conducted a meta-analysis of associations between the TRAF1-C5 polymorphisms and RA susceptibility. Results: A total of 24 comparative studies were included in this meta-analysis, including 22,682 patients with RA and 23,493 controls. The meta-analysis showed an association between the second allele of rs10818488 and RA in Europeans, but not in Asians (OR 1.229, 95% CI 1.094-1.381, p = 0.001; OR 1.060, 95% CI 0.930-1.335, p = 0.092). The meta-analysis also indicated an association between the second allele of rs3761847 and RA in Europeans, but not in Asians (OR 1.156, 95% CI 1.006-1.327, p = 0.041; OR 1.049, 95% CI 0.952-1.156, p = 0.333). The meta-analysis revealed an association between the second allele of the rs2900180 and rs10760130 polymorphisms and RA risk in Europeans (OR 1.224, 95% CI 1.065-1.405, p = 0.004; OR 1.072, 95% CI 1.002-1.147, p = 0.042). Conclusions: This meta-analysis confirms that the TRAF1-C5 rs10818488, rs3761847, rs2900180 and rs10760130 polymorphisms are associated with RA susceptibility in Europeans.
KW - Meta-analysis
KW - Polymorphism
KW - Rheumatoid arthritis
KW - TRAF1-C5
UR - http://www.scopus.com/inward/record.url?scp=84893423258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893423258&partnerID=8YFLogxK
U2 - 10.3109/08820139.2013.837917
DO - 10.3109/08820139.2013.837917
M3 - Article
C2 - 24144456
AN - SCOPUS:84893423258
VL - 43
SP - 97
EP - 112
JO - Immunological Investigations
JF - Immunological Investigations
SN - 0882-0139
IS - 2
ER -