Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: Meta-analysis

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Abstract

The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls. A meta-analysis was conducted on the associations of the TNF-α -308A/G, -238A/G, and -857T/C polymorphisms with PTB susceptibility. A total of 13 studies met the inclusion criteria, including 12, 6, and 4 studies on TNF-α-308A/G, -238A/G, and -857T/C polymorphisms, respectively. Meta-analysis showed no association between the TNF-α -308A allele and PTB susceptibility in all study subjects (odds ratio, OR = 1.182, 95%CI = 0.989-1.411, P = 0.066). After stratification by ethnicity, TNF-α -308A was not found to be associated with PTB in the European, Asian, or Middle East populations. No association was identified between PTB susceptibility and the TNF-α -238A allele in all study subjects (OR = 1.031, 95%CI = 0.741-1.436, P = 0.855), or in the European and Asian populations. However, TNF-α -857T was significantly associated with PTB susceptibility specifically in Asians (OR = 0.682, 95%CI = 0.550-0.846, P = 4.8 x 10-5). Meta-analysis using the dominant model, recessive model, or homozygote contrast showed the same pattern of results as for the TNF-α -857T allele. Overall, no correlation was noted between the TNF-α -308A/G and -238A/G polymorphisms and PTB susceptibility. However, the TNF-α -857T/C polymorphism was found to be associated with PTB susceptibility in the Asian population.

Original languageEnglish
Pages (from-to)8602-8612
Number of pages11
JournalGenetics and Molecular Research
Volume14
Issue number3
DOIs
Publication statusPublished - 2015 Jul 31

Fingerprint

Pulmonary Tuberculosis
Meta-Analysis
Tumor Necrosis Factor-alpha
Alleles
Population
Lymphotoxin-beta
Middle East
Homozygote
MEDLINE
Odds Ratio
Databases

Keywords

  • Meta-analysis
  • Polymorphism
  • Pulmonary tuberculosis
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

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title = "Associations between tumor necrosis factor-α polymorphisms and susceptibility to pulmonary tuberculosis: Meta-analysis",
abstract = "The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls. A meta-analysis was conducted on the associations of the TNF-α -308A/G, -238A/G, and -857T/C polymorphisms with PTB susceptibility. A total of 13 studies met the inclusion criteria, including 12, 6, and 4 studies on TNF-α-308A/G, -238A/G, and -857T/C polymorphisms, respectively. Meta-analysis showed no association between the TNF-α -308A allele and PTB susceptibility in all study subjects (odds ratio, OR = 1.182, 95{\%}CI = 0.989-1.411, P = 0.066). After stratification by ethnicity, TNF-α -308A was not found to be associated with PTB in the European, Asian, or Middle East populations. No association was identified between PTB susceptibility and the TNF-α -238A allele in all study subjects (OR = 1.031, 95{\%}CI = 0.741-1.436, P = 0.855), or in the European and Asian populations. However, TNF-α -857T was significantly associated with PTB susceptibility specifically in Asians (OR = 0.682, 95{\%}CI = 0.550-0.846, P = 4.8 x 10-5). Meta-analysis using the dominant model, recessive model, or homozygote contrast showed the same pattern of results as for the TNF-α -857T allele. Overall, no correlation was noted between the TNF-α -308A/G and -238A/G polymorphisms and PTB susceptibility. However, the TNF-α -857T/C polymorphism was found to be associated with PTB susceptibility in the Asian population.",
keywords = "Meta-analysis, Polymorphism, Pulmonary tuberculosis, Tumor necrosis factor",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2015",
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AU - Lee, Young Ho

AU - Song, Gwan Gyu

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N2 - The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls. A meta-analysis was conducted on the associations of the TNF-α -308A/G, -238A/G, and -857T/C polymorphisms with PTB susceptibility. A total of 13 studies met the inclusion criteria, including 12, 6, and 4 studies on TNF-α-308A/G, -238A/G, and -857T/C polymorphisms, respectively. Meta-analysis showed no association between the TNF-α -308A allele and PTB susceptibility in all study subjects (odds ratio, OR = 1.182, 95%CI = 0.989-1.411, P = 0.066). After stratification by ethnicity, TNF-α -308A was not found to be associated with PTB in the European, Asian, or Middle East populations. No association was identified between PTB susceptibility and the TNF-α -238A allele in all study subjects (OR = 1.031, 95%CI = 0.741-1.436, P = 0.855), or in the European and Asian populations. However, TNF-α -857T was significantly associated with PTB susceptibility specifically in Asians (OR = 0.682, 95%CI = 0.550-0.846, P = 4.8 x 10-5). Meta-analysis using the dominant model, recessive model, or homozygote contrast showed the same pattern of results as for the TNF-α -857T allele. Overall, no correlation was noted between the TNF-α -308A/G and -238A/G polymorphisms and PTB susceptibility. However, the TNF-α -857T/C polymorphism was found to be associated with PTB susceptibility in the Asian population.

AB - The aim of this study was to determine whether tumor necrosis factor-α (TNF-α) polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB) in different ethnic populations. MEDLINE and Embase databases and manual searches were employed to identify articles in which TNF-α polymorphisms were determined in patients with PTB and controls. A meta-analysis was conducted on the associations of the TNF-α -308A/G, -238A/G, and -857T/C polymorphisms with PTB susceptibility. A total of 13 studies met the inclusion criteria, including 12, 6, and 4 studies on TNF-α-308A/G, -238A/G, and -857T/C polymorphisms, respectively. Meta-analysis showed no association between the TNF-α -308A allele and PTB susceptibility in all study subjects (odds ratio, OR = 1.182, 95%CI = 0.989-1.411, P = 0.066). After stratification by ethnicity, TNF-α -308A was not found to be associated with PTB in the European, Asian, or Middle East populations. No association was identified between PTB susceptibility and the TNF-α -238A allele in all study subjects (OR = 1.031, 95%CI = 0.741-1.436, P = 0.855), or in the European and Asian populations. However, TNF-α -857T was significantly associated with PTB susceptibility specifically in Asians (OR = 0.682, 95%CI = 0.550-0.846, P = 4.8 x 10-5). Meta-analysis using the dominant model, recessive model, or homozygote contrast showed the same pattern of results as for the TNF-α -857T allele. Overall, no correlation was noted between the TNF-α -308A/G and -238A/G polymorphisms and PTB susceptibility. However, the TNF-α -857T/C polymorphism was found to be associated with PTB susceptibility in the Asian population.

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