Associations of obesity with lipoprotein subfractions in Japanese American, African American, and Korean men

Nobutaka Hirooka, Chol Shin, Kamal H. Masaki, Daniel Edmundowicz, Jina Choo, Emma J M Barinas-Mitchell, Bradley J. Willcox, Kim Sutton-Tyrrell, Aiman El-Saed, Iva Miljkovic-Gacic, Takayoshi Ohkubo, Katsuyuki Miura, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups. Objective This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions. Methods A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity - that is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index - and for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein. Conclusions VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R2 values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalGlobal Heart
Volume8
Issue number3
DOIs
Publication statusPublished - 2013 Jan 1

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Asian Americans
Ethnic Groups
African Americans
Lipoproteins
Obesity
HDL Lipoproteins
LDL Lipoproteins
Waist Circumference
Body Mass Index
Intra-Abdominal Fat
Subcutaneous Fat
Coronary Disease
Magnetic Resonance Spectroscopy
Regression Analysis
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Epidemiology
  • Community and Home Care

Cite this

Associations of obesity with lipoprotein subfractions in Japanese American, African American, and Korean men. / Hirooka, Nobutaka; Shin, Chol; Masaki, Kamal H.; Edmundowicz, Daniel; Choo, Jina; Barinas-Mitchell, Emma J M; Willcox, Bradley J.; Sutton-Tyrrell, Kim; El-Saed, Aiman; Miljkovic-Gacic, Iva; Ohkubo, Takayoshi; Miura, Katsuyuki; Ueshima, Hirotsugu; Kuller, Lewis H.; Sekikawa, Akira.

In: Global Heart, Vol. 8, No. 3, 01.01.2013, p. 273-280.

Research output: Contribution to journalArticle

Hirooka, N, Shin, C, Masaki, KH, Edmundowicz, D, Choo, J, Barinas-Mitchell, EJM, Willcox, BJ, Sutton-Tyrrell, K, El-Saed, A, Miljkovic-Gacic, I, Ohkubo, T, Miura, K, Ueshima, H, Kuller, LH & Sekikawa, A 2013, 'Associations of obesity with lipoprotein subfractions in Japanese American, African American, and Korean men', Global Heart, vol. 8, no. 3, pp. 273-280. https://doi.org/10.1016/j.gheart.2013.07.001
Hirooka, Nobutaka ; Shin, Chol ; Masaki, Kamal H. ; Edmundowicz, Daniel ; Choo, Jina ; Barinas-Mitchell, Emma J M ; Willcox, Bradley J. ; Sutton-Tyrrell, Kim ; El-Saed, Aiman ; Miljkovic-Gacic, Iva ; Ohkubo, Takayoshi ; Miura, Katsuyuki ; Ueshima, Hirotsugu ; Kuller, Lewis H. ; Sekikawa, Akira. / Associations of obesity with lipoprotein subfractions in Japanese American, African American, and Korean men. In: Global Heart. 2013 ; Vol. 8, No. 3. pp. 273-280.
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abstract = "Background Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups. Objective This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions. Methods A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity - that is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index - and for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein. Conclusions VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R2 values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.",
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T1 - Associations of obesity with lipoprotein subfractions in Japanese American, African American, and Korean men

AU - Hirooka, Nobutaka

AU - Shin, Chol

AU - Masaki, Kamal H.

AU - Edmundowicz, Daniel

AU - Choo, Jina

AU - Barinas-Mitchell, Emma J M

AU - Willcox, Bradley J.

AU - Sutton-Tyrrell, Kim

AU - El-Saed, Aiman

AU - Miljkovic-Gacic, Iva

AU - Ohkubo, Takayoshi

AU - Miura, Katsuyuki

AU - Ueshima, Hirotsugu

AU - Kuller, Lewis H.

AU - Sekikawa, Akira

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups. Objective This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions. Methods A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity - that is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index - and for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein. Conclusions VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R2 values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.

AB - Background Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups. Objective This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions. Methods A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity - that is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index - and for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein. Conclusions VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R2 values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.

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