Astaxanthin inhibits proliferation of human gastric cancer cell lines by interrupting cell cycle progression

Jung Ha Kim, Jong Jae Park, Beom Jae Lee, Moon Kyung Joo, Hoon Jai Chun, Sang Woo Lee, Young Tae Bak

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    Background/Aims: Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. Methods: The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45, and SNU-1 were treated with various concentrations of astaxanthin. A cell viability test, cell cycle analysis, and immunoblotting were performed. Results: The viability of each cancer cell line was suppressed by astaxanthin in a dose-dependent manner with significantly decreased proliferation in KATO-III and SNU-1 cells. Astaxanthin increased the number of cells in the G0/G1 phase but reduced the proportion of S phase KATO-III and SNU-1 cells. Phosphorylated extracellular signal-regulated kinase (ERK) was decreased in an inverse dose-dependent correlation with astaxanthin concentration, and the expression of p27kip-1 increased the KATO-III and SNU-1 cell lines in an astaxanthin dose-dependent manner. Conclusions: Astaxanthin inhibits proliferation by interrupting cell cycle progression in KATO-III and SNU-1 gastric cancer cells. This may be caused by the inhibition of the phosphorylation of ERK and the enhanced expression of p27kip-1.

    Original languageEnglish
    Pages (from-to)369-374
    Number of pages6
    JournalGut and liver
    Volume10
    Issue number3
    DOIs
    Publication statusPublished - 2016

    Keywords

    • Astaxanthin
    • Extracellular signal-regulated kinase
    • Human gastric adenocarcinoma
    • P27
    • Proliferation

    ASJC Scopus subject areas

    • Hepatology
    • Gastroenterology

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