Asthma control test reflects not only lung function but also airway inflammation in children with stable asthma

Woo Yeon Lee, Dong In Suh, Dae-Jin Song, Hey Sung Baek, Meeyong Shin, Young Yoo, Ji Won Kwon, Gwang Cheon Jang, Hyeon Jong Yang, Eun Lee, Ju Hee Seo, Sung Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon, Sungsu Jung, Minkyu Han, Eunjin Eom, Jinho Yu & 6 others Woo Kyung Kim, Dae Hyun Lim, Jin Tack Kim, Woo Sung Chang, Jeom Kyu Lee, Hwan Soo Kim

Research output: Contribution to journalArticle

Abstract

Objective: Various numerical asthma control tools have been developed to distinguish different levels of symptom control. We aimed to examine whether the asthma control test (ACT) is reflective of objective findings such as lung function, fractional exhaled nitric oxide (FeNO) and laboratory data in patients with stable asthma. Methods: We included patients who were enrolled in the Korean Childhood Asthma Study. ACT, spirometry, blood tests and FeNO were performed in patients after stabilization of their asthma. We examined differences among spirometry parameters, blood tests and FeNO according to control status as determined by ACT and investigated for any significant correlations. Results: The study population consisted of 441 subjects. Spirometry showed that forced expiratory volume in one second (FEV 1 ), forced expiratory flow between 25% and 75% of forced vital capacity and FEV 1 /forced vital capacity were all significantly higher in the controlled asthma group. Likewise, FeNO and percent-change in FEV 1 were both significantly lower in the controlled asthma group. In blood tests, the eosinophil fraction was significantly lower in the controlled asthma group while white blood cell count was significantly higher in the controlled asthma group. Lastly, among the various factors analyzed, only provocative concentration of methacholine causing a 20% fall in FEV 1 significantly correlated with ACT score. Conclusion: ACT is useful as part of the routine evaluation of asthmatic children and should be used as a complement to existing tools such as spirometry and FeNO measurement.

Original languageEnglish
JournalJournal of Asthma
DOIs
Publication statusPublished - 2019 Jan 1

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Asthma
Inflammation
Lung
Spirometry
Nitric Oxide
Hematologic Tests
Vital Capacity
Methacholine Chloride
Forced Expiratory Volume
Leukocyte Count
Eosinophils

Keywords

  • Asthma control test
  • bronchial hyperreactivity
  • bronchodilator response
  • children
  • fractional exhaled nitric oxide
  • spirometry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Asthma control test reflects not only lung function but also airway inflammation in children with stable asthma. / Lee, Woo Yeon; Suh, Dong In; Song, Dae-Jin; Baek, Hey Sung; Shin, Meeyong; Yoo, Young; Kwon, Ji Won; Jang, Gwang Cheon; Yang, Hyeon Jong; Lee, Eun; Seo, Ju Hee; Woo, Sung Il; Kim, Hyung Young; Shin, Youn Ho; Lee, Ju Suk; Yoon, Jisun; Jung, Sungsu; Han, Minkyu; Eom, Eunjin; Yu, Jinho; Kim, Woo Kyung; Lim, Dae Hyun; Kim, Jin Tack; Chang, Woo Sung; Lee, Jeom Kyu; Kim, Hwan Soo.

In: Journal of Asthma, 01.01.2019.

Research output: Contribution to journalArticle

Lee, WY, Suh, DI, Song, D-J, Baek, HS, Shin, M, Yoo, Y, Kwon, JW, Jang, GC, Yang, HJ, Lee, E, Seo, JH, Woo, SI, Kim, HY, Shin, YH, Lee, JS, Yoon, J, Jung, S, Han, M, Eom, E, Yu, J, Kim, WK, Lim, DH, Kim, JT, Chang, WS, Lee, JK & Kim, HS 2019, 'Asthma control test reflects not only lung function but also airway inflammation in children with stable asthma', Journal of Asthma. https://doi.org/10.1080/02770903.2019.1599386
Lee, Woo Yeon ; Suh, Dong In ; Song, Dae-Jin ; Baek, Hey Sung ; Shin, Meeyong ; Yoo, Young ; Kwon, Ji Won ; Jang, Gwang Cheon ; Yang, Hyeon Jong ; Lee, Eun ; Seo, Ju Hee ; Woo, Sung Il ; Kim, Hyung Young ; Shin, Youn Ho ; Lee, Ju Suk ; Yoon, Jisun ; Jung, Sungsu ; Han, Minkyu ; Eom, Eunjin ; Yu, Jinho ; Kim, Woo Kyung ; Lim, Dae Hyun ; Kim, Jin Tack ; Chang, Woo Sung ; Lee, Jeom Kyu ; Kim, Hwan Soo. / Asthma control test reflects not only lung function but also airway inflammation in children with stable asthma. In: Journal of Asthma. 2019.
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abstract = "Objective: Various numerical asthma control tools have been developed to distinguish different levels of symptom control. We aimed to examine whether the asthma control test (ACT) is reflective of objective findings such as lung function, fractional exhaled nitric oxide (FeNO) and laboratory data in patients with stable asthma. Methods: We included patients who were enrolled in the Korean Childhood Asthma Study. ACT, spirometry, blood tests and FeNO were performed in patients after stabilization of their asthma. We examined differences among spirometry parameters, blood tests and FeNO according to control status as determined by ACT and investigated for any significant correlations. Results: The study population consisted of 441 subjects. Spirometry showed that forced expiratory volume in one second (FEV 1 ), forced expiratory flow between 25{\%} and 75{\%} of forced vital capacity and FEV 1 /forced vital capacity were all significantly higher in the controlled asthma group. Likewise, FeNO and percent-change in FEV 1 were both significantly lower in the controlled asthma group. In blood tests, the eosinophil fraction was significantly lower in the controlled asthma group while white blood cell count was significantly higher in the controlled asthma group. Lastly, among the various factors analyzed, only provocative concentration of methacholine causing a 20{\%} fall in FEV 1 significantly correlated with ACT score. Conclusion: ACT is useful as part of the routine evaluation of asthmatic children and should be used as a complement to existing tools such as spirometry and FeNO measurement.",
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AU - Lee, Woo Yeon

AU - Suh, Dong In

AU - Song, Dae-Jin

AU - Baek, Hey Sung

AU - Shin, Meeyong

AU - Yoo, Young

AU - Kwon, Ji Won

AU - Jang, Gwang Cheon

AU - Yang, Hyeon Jong

AU - Lee, Eun

AU - Seo, Ju Hee

AU - Woo, Sung Il

AU - Kim, Hyung Young

AU - Shin, Youn Ho

AU - Lee, Ju Suk

AU - Yoon, Jisun

AU - Jung, Sungsu

AU - Han, Minkyu

AU - Eom, Eunjin

AU - Yu, Jinho

AU - Kim, Woo Kyung

AU - Lim, Dae Hyun

AU - Kim, Jin Tack

AU - Chang, Woo Sung

AU - Lee, Jeom Kyu

AU - Kim, Hwan Soo

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: Various numerical asthma control tools have been developed to distinguish different levels of symptom control. We aimed to examine whether the asthma control test (ACT) is reflective of objective findings such as lung function, fractional exhaled nitric oxide (FeNO) and laboratory data in patients with stable asthma. Methods: We included patients who were enrolled in the Korean Childhood Asthma Study. ACT, spirometry, blood tests and FeNO were performed in patients after stabilization of their asthma. We examined differences among spirometry parameters, blood tests and FeNO according to control status as determined by ACT and investigated for any significant correlations. Results: The study population consisted of 441 subjects. Spirometry showed that forced expiratory volume in one second (FEV 1 ), forced expiratory flow between 25% and 75% of forced vital capacity and FEV 1 /forced vital capacity were all significantly higher in the controlled asthma group. Likewise, FeNO and percent-change in FEV 1 were both significantly lower in the controlled asthma group. In blood tests, the eosinophil fraction was significantly lower in the controlled asthma group while white blood cell count was significantly higher in the controlled asthma group. Lastly, among the various factors analyzed, only provocative concentration of methacholine causing a 20% fall in FEV 1 significantly correlated with ACT score. Conclusion: ACT is useful as part of the routine evaluation of asthmatic children and should be used as a complement to existing tools such as spirometry and FeNO measurement.

AB - Objective: Various numerical asthma control tools have been developed to distinguish different levels of symptom control. We aimed to examine whether the asthma control test (ACT) is reflective of objective findings such as lung function, fractional exhaled nitric oxide (FeNO) and laboratory data in patients with stable asthma. Methods: We included patients who were enrolled in the Korean Childhood Asthma Study. ACT, spirometry, blood tests and FeNO were performed in patients after stabilization of their asthma. We examined differences among spirometry parameters, blood tests and FeNO according to control status as determined by ACT and investigated for any significant correlations. Results: The study population consisted of 441 subjects. Spirometry showed that forced expiratory volume in one second (FEV 1 ), forced expiratory flow between 25% and 75% of forced vital capacity and FEV 1 /forced vital capacity were all significantly higher in the controlled asthma group. Likewise, FeNO and percent-change in FEV 1 were both significantly lower in the controlled asthma group. In blood tests, the eosinophil fraction was significantly lower in the controlled asthma group while white blood cell count was significantly higher in the controlled asthma group. Lastly, among the various factors analyzed, only provocative concentration of methacholine causing a 20% fall in FEV 1 significantly correlated with ACT score. Conclusion: ACT is useful as part of the routine evaluation of asthmatic children and should be used as a complement to existing tools such as spirometry and FeNO measurement.

KW - Asthma control test

KW - bronchial hyperreactivity

KW - bronchodilator response

KW - children

KW - fractional exhaled nitric oxide

KW - spirometry

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