Astrocytes as GABA-ergic and GABA-ceptive cells

Bo Eun Yoon, Junsung Woo, C. Justin Lee

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

GABA (gamma-aminobutyric acid) is considered to be the major inhibitory neurotransmitter that is synthesized in and released from GABA-ergic neurons in the brain. However, recent studies have shown that not only neurons but astrocytes contain a considerable amount of GABA, which can be released and activate the receptors responsive to GABA. In addition, astrocytes are themselves responsive to GABA by expressing GABA receptors. These exciting new findings raise more questions about the origin of GABA, whether it is synthesized or taken up, and about the role of astrocytic GABA and GABA receptors. In this review, we propose several potential pathways for astrocytes to accumulate GABA and discuss the evidence for functional expression of GABA receptors in astrocytes.

Original languageEnglish
Pages (from-to)2474-2479
Number of pages6
JournalNeurochemical Research
Volume37
Issue number11
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • Astrocyte
  • Glial GABA
  • Tonic inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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