A dual neutral-cationic rhodium(I)-catalyzed Pauson-Khand-type reaction using formaldehyde as a carbonyl source is described. The simultaneous use of neutral rhodium(I) and cationic rhodium(I) complexes is required for efficient cooperative catalysis, which involves the neutral rhodium(I)-catalyzed decarbonylation of formaldehyde and the cationic rhodium(I)-catalyzed cyclocarbonylation of 1,6-enynes using the resulting carbonyl moiety.
- Asymmetric Pauson-Khand reaction
- Dual catalysis
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery