Atlas-based multichannel monitoring of functional MRI signals in real-time

Automated approach

Jong-Hwan Lee, Heather M. O'Leary, Hyunwook Park, Ferenc A. Jolesz, Seung Schik Yoo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We report an automated method to simultaneously monitor blood-oxygenation-level-dependent (BOLD) MR signals from multiple cortical areas in real-time. Individual brain anatomy was normalized and registered to a pre-segmented atlas in standardized anatomical space. Subsequently, using real-time fMRI (rtfMRI) data acquisition, localized BOLD signals were measured and displayed from user-selected areas labeled with anatomical and Brodmann's Area (BA) nomenclature. The method was tested on healthy volunteers during the performance of hand motor and internal speech generation tasks employing a trial-based design. Our data normalization and registration algorithm, along with image reconstruction, movement correction and a data display routine were executed with enough processing and communication bandwidth necessary for real-time operation. Task-specific BOLD signals were observed from the hand motor and language areas. One of the study participants was allowed to freely engage in hand clenching tasks, and associated brain activities were detected from the motor-related neural substrates without prior knowledge of the task onset time. The proposed method may be applied to various applications such as neurofeedback, brain-computer-interface, and functional mapping for surgical planning where real-time monitoring of region-specific brain activity is needed.

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalHuman Brain Mapping
Volume29
Issue number2
DOIs
Publication statusPublished - 2008 Feb 1
Externally publishedYes

Fingerprint

Atlases
Magnetic Resonance Imaging
Hand
Brain
Neurofeedback
Data Display
Brain-Computer Interfaces
Computer-Assisted Image Processing
Motor Cortex
Terminology
Anatomy
Healthy Volunteers
Language
Communication

Keywords

  • Brain-computer-interface
  • EEG
  • Evoked-potential
  • fMRI
  • Neurofeedback
  • Surgical planning

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Atlas-based multichannel monitoring of functional MRI signals in real-time : Automated approach. / Lee, Jong-Hwan; O'Leary, Heather M.; Park, Hyunwook; Jolesz, Ferenc A.; Yoo, Seung Schik.

In: Human Brain Mapping, Vol. 29, No. 2, 01.02.2008, p. 157-166.

Research output: Contribution to journalArticle

Lee, Jong-Hwan ; O'Leary, Heather M. ; Park, Hyunwook ; Jolesz, Ferenc A. ; Yoo, Seung Schik. / Atlas-based multichannel monitoring of functional MRI signals in real-time : Automated approach. In: Human Brain Mapping. 2008 ; Vol. 29, No. 2. pp. 157-166.
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