Atrophic gastritis

A related factor for osteoporosis in elderly women

Hye Won Kim, Yang-Hyun Kim, Kyungdo Han, Ga Eun Nam, Gwang Seon Kim, Byoung Duck Han, Anna Lee, Ji Yong Ahn, Byung Joon Ko

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. Subjects and Methods: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. Results: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15-3.11). Conclusions: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.

Original languageEnglish
Article numbere101852
JournalPloS one
Volume9
Issue number7
DOIs
Publication statusPublished - 2014 Jul 8

Fingerprint

Atrophic Gastritis
gastritis
osteoporosis
Regression analysis
HDL Cholesterol
Osteoporosis
Minerals
Logistics
Bone
Triglycerides
Aging of materials
Alcohols
X rays
Acids
osteopenia
gastric acid
lumbar spine
Postmenopausal Osteoporosis
dual-energy X-ray absorptiometry
densitometry

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, H. W., Kim, Y-H., Han, K., Nam, G. E., Kim, G. S., Han, B. D., ... Ko, B. J. (2014). Atrophic gastritis: A related factor for osteoporosis in elderly women. PloS one, 9(7), [e101852]. https://doi.org/10.1371/journal.pone.0101852

Atrophic gastritis : A related factor for osteoporosis in elderly women. / Kim, Hye Won; Kim, Yang-Hyun; Han, Kyungdo; Nam, Ga Eun; Kim, Gwang Seon; Han, Byoung Duck; Lee, Anna; Ahn, Ji Yong; Ko, Byung Joon.

In: PloS one, Vol. 9, No. 7, e101852, 08.07.2014.

Research output: Contribution to journalArticle

Kim, HW, Kim, Y-H, Han, K, Nam, GE, Kim, GS, Han, BD, Lee, A, Ahn, JY & Ko, BJ 2014, 'Atrophic gastritis: A related factor for osteoporosis in elderly women', PloS one, vol. 9, no. 7, e101852. https://doi.org/10.1371/journal.pone.0101852
Kim, Hye Won ; Kim, Yang-Hyun ; Han, Kyungdo ; Nam, Ga Eun ; Kim, Gwang Seon ; Han, Byoung Duck ; Lee, Anna ; Ahn, Ji Yong ; Ko, Byung Joon. / Atrophic gastritis : A related factor for osteoporosis in elderly women. In: PloS one. 2014 ; Vol. 9, No. 7.
@article{f95a02b774d44816ab061749512214e2,
title = "Atrophic gastritis: A related factor for osteoporosis in elderly women",
abstract = "Purpose: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. Subjects and Methods: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. Results: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95{\%} confidence interval 1.15-3.11). Conclusions: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.",
author = "Kim, {Hye Won} and Yang-Hyun Kim and Kyungdo Han and Nam, {Ga Eun} and Kim, {Gwang Seon} and Han, {Byoung Duck} and Anna Lee and Ahn, {Ji Yong} and Ko, {Byung Joon}",
year = "2014",
month = "7",
day = "8",
doi = "10.1371/journal.pone.0101852",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

TY - JOUR

T1 - Atrophic gastritis

T2 - A related factor for osteoporosis in elderly women

AU - Kim, Hye Won

AU - Kim, Yang-Hyun

AU - Han, Kyungdo

AU - Nam, Ga Eun

AU - Kim, Gwang Seon

AU - Han, Byoung Duck

AU - Lee, Anna

AU - Ahn, Ji Yong

AU - Ko, Byung Joon

PY - 2014/7/8

Y1 - 2014/7/8

N2 - Purpose: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. Subjects and Methods: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. Results: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15-3.11). Conclusions: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.

AB - Purpose: Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. Subjects and Methods: A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. Results: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15-3.11). Conclusions: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.

UR - http://www.scopus.com/inward/record.url?scp=84903904583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903904583&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0101852

DO - 10.1371/journal.pone.0101852

M3 - Article

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 7

M1 - e101852

ER -