Attenuated neuropathic pain in CaV3.1 null mice

Heung Sik Na, Soonwook Choi, Junesun Kim, Joonoh Park, Hee Sup Shin

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Abstract

To assess the role of αIG T-type Ca2- channels in neuropathic pain After L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Cav3.1 (αIG --), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw with drawal in response to mechanical stimulation were observed in these mice. The αIG -- mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of neuropathic pain, Ca2- channels in the development of neuropathic pain, and suggest that selective modulation of αIG subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

Original languageEnglish
Pages (from-to)242-246
Number of pages5
JournalMolecules and Cells
Volume25
Issue number2
Publication statusPublished - 2008 Apr 30

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Keywords

  • Allodynia
  • Central sensitization
  • Hyperalgesia
  • Spinal nerve ligation (SNL)
  • T-type calcium channel

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Na, H. S., Choi, S., Kim, J., Park, J., & Shin, H. S. (2008). Attenuated neuropathic pain in CaV3.1 null mice. Molecules and Cells, 25(2), 242-246.