Augmentation of glans penis using injectable hyaluronic acid gel

D. G. Moon, T. I. Kwak, H. Y. Cho, J. H. Bael, H. S. Park, J. J. Kim

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Recently, injectable hyaluronic acid gel has been widely used in soft-tissue augmentation. We performed this study to identify the feasibility of hyaluronic acid gel for the augmentation of the glans penis. In experiment I, 0.2 cm3 of hyaluronic acid gel (HA) was injected into the dermis of the glans penis of 25 New Zealand white rabbits via a 30 G needle. At 3, 7, 14, 30, and 90 days after injection, histological changes of glans were studied, respectively. In experiment II, 0.5 cm3 of HA was injected into the dermis of the glans penis of 14 Beagle dogs via a 27 G needle. At 6 months after injection, histological changes of the glans penis were also evaluated. At the time of autopsy, the lung, liver, and spleen were studied for systemic adverse reaction in each separate experiment. In experiment I, various sized cavities filled with amorphous basophilic materials were noted in the lamina propria and corpus spongiosum of the glans penis. All implants were positively stained on alcian blue. The intensity decreased in a time-dependent manner. Until 14 days, minimal inflammatory reactions were noted, but no signs of inflammation were identified at 90 days. With the gradual decrease of inflammation, fibrosis and deposition of collagen were noted. In experiment II, implants were well maintained at 6 months after injection in the lamina propria. Grade 1 of the inflammatory reaction was noted in one case. In both the experiments, all the specimens were free from any foreign body reaction and systemic adverse reactions. In conclusion, these results suggest that hyaluronic acid gel can be easily injected into the lamina propria of the glans penis and reside until 6 months. Injectable hyaluronic acid gel has a potential as a new bioimplant for the augmentation of the glans penis.

    Original languageEnglish
    Pages (from-to)456-460
    Number of pages5
    JournalInternational Journal of Impotence Research
    Volume15
    Issue number6
    DOIs
    Publication statusPublished - 2003 Nov

    Keywords

    • Augmentation
    • Glans penis
    • Hyaluronic acid

    ASJC Scopus subject areas

    • Urology

    Fingerprint

    Dive into the research topics of 'Augmentation of glans penis using injectable hyaluronic acid gel'. Together they form a unique fingerprint.

    Cite this