Augmented death in immunostimulated astrocytes deprived of glucose: Inhibition by an iron porphyrin FeTMPyP

In Young Choi, Sun Jung Lee, Wonwoo Nam, Jong Sun Park, Kwang Ho Ko, Hyoung Chun Kim, Chan Young Shin, Jang Hyun Chung, Seo Kyu Noh, Chang Rak Choi, Dong Hoon Shin, Won Ki Kim

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16 Citations (Scopus)

Abstract

The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H2TMPyP, prevented the death in glucose-deprived immunostimulated astrocytes. Consistently, FeTMPyP, not ZnTMPyP and H2TMPyP, completely blocked the elevation of nitrotyrosine immunoreactivity (a marker of peroxynitrite) and the depolarization of the mitochondrial transmembrane potential in glucose-deprived immunostimulated astrocytes. The present data suggest that peroxynitrite may be associated with glial cell death during metabolic deterioration in the cerebral ischemic penumbra. (C) 2001 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Neuroimmunology
Volume112
Issue number1-2
DOIs
Publication statusPublished - 2001 Jan 1

Keywords

  • Astrocyte
  • FeTMPyP
  • Glucose deprivation
  • Mitochondria transmembrane potential
  • Peroxynitrite

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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    Choi, I. Y., Lee, S. J., Nam, W., Park, J. S., Ko, K. H., Kim, H. C., Shin, C. Y., Chung, J. H., Noh, S. K., Choi, C. R., Shin, D. H., & Kim, W. K. (2001). Augmented death in immunostimulated astrocytes deprived of glucose: Inhibition by an iron porphyrin FeTMPyP. Journal of Neuroimmunology, 112(1-2), 55-62. https://doi.org/10.1016/S0165-5728(00)00382-9