Augmented death in immunostimulated astrocytes deprived of glucose: Inhibition by an iron porphyrin FeTMPyP

In Young Choi, Sun Jung Lee, Wonwoo Nam, Jong Sun Park, Kwang Ho Ko, Hyoung Chun Kim, Chan Young Shin, Jang Hyun Chung, Seo Kyu Noh, Chang Rak Choi, Dong Hoon Shin, Won-Ki Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The present study shows that under glucose-deprived conditions immunostimulated astrocytes rapidly undergo death due to their increased susceptibility to endogenously produced peroxynitrite. Fe(III)tetrakis(N-methyl-4'-pyridyl)porphyrin (FeTMPyP), but not the structurally related compounds ZnTMPyP and H2TMPyP, prevented the death in glucose-deprived immunostimulated astrocytes. Consistently, FeTMPyP, not ZnTMPyP and H2TMPyP, completely blocked the elevation of nitrotyrosine immunoreactivity (a marker of peroxynitrite) and the depolarization of the mitochondrial transmembrane potential in glucose-deprived immunostimulated astrocytes. The present data suggest that peroxynitrite may be associated with glial cell death during metabolic deterioration in the cerebral ischemic penumbra. (C) 2001 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Neuroimmunology
Volume112
Issue number1-2
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

Fingerprint

Peroxynitrous Acid
Porphyrins
Astrocytes
Iron
Glucose
Neuroglia
Membrane Potentials
Cell Death

Keywords

  • Astrocyte
  • FeTMPyP
  • Glucose deprivation
  • Mitochondria transmembrane potential
  • Peroxynitrite

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Augmented death in immunostimulated astrocytes deprived of glucose : Inhibition by an iron porphyrin FeTMPyP. / Choi, In Young; Lee, Sun Jung; Nam, Wonwoo; Park, Jong Sun; Ko, Kwang Ho; Kim, Hyoung Chun; Shin, Chan Young; Chung, Jang Hyun; Noh, Seo Kyu; Choi, Chang Rak; Shin, Dong Hoon; Kim, Won-Ki.

In: Journal of Neuroimmunology, Vol. 112, No. 1-2, 01.01.2001, p. 55-62.

Research output: Contribution to journalArticle

Choi, IY, Lee, SJ, Nam, W, Park, JS, Ko, KH, Kim, HC, Shin, CY, Chung, JH, Noh, SK, Choi, CR, Shin, DH & Kim, W-K 2001, 'Augmented death in immunostimulated astrocytes deprived of glucose: Inhibition by an iron porphyrin FeTMPyP', Journal of Neuroimmunology, vol. 112, no. 1-2, pp. 55-62. https://doi.org/10.1016/S0165-5728(00)00382-9
Choi, In Young ; Lee, Sun Jung ; Nam, Wonwoo ; Park, Jong Sun ; Ko, Kwang Ho ; Kim, Hyoung Chun ; Shin, Chan Young ; Chung, Jang Hyun ; Noh, Seo Kyu ; Choi, Chang Rak ; Shin, Dong Hoon ; Kim, Won-Ki. / Augmented death in immunostimulated astrocytes deprived of glucose : Inhibition by an iron porphyrin FeTMPyP. In: Journal of Neuroimmunology. 2001 ; Vol. 112, No. 1-2. pp. 55-62.
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