Aurora kinase A promotes hepatitis B virus replication and expression

Gi Uk Jeong, Byung-Yoon Ahn

Research output: Contribution to journalArticle

Abstract

Cellular protein kinases play critical roles in various steps of the hepatitis B virus life cycle. We found that viral replication in infected or transfected hepatoma cell was markedly inhibited by treatment with A-443654, a specific inhibitor of Akt. The antiviral mechanism of the drug mainly depended on the downregulation of Aurora A, a protein kinase that plays an essential role in mitosis but has not been implicated in the viral life cycle. Our data indicated that Aurora kinase A enhances viral replication and expression independently of its kinase activity required for mitotic function. Our findings suggest that mitotic kinases, considered to be an attractive target of antitumor agents, also provide a novel target for the development of antiviral therapy.

Original languageEnglish
Article number104572
JournalAntiviral Research
Volume170
DOIs
Publication statusPublished - 2019 Oct 1

Fingerprint

Aurora Kinase A
Virus Replication
Life Cycle Stages
Hepatitis B virus
Protein Kinases
Antiviral Agents
Phosphotransferases
Mitosis
Antineoplastic Agents
Hepatocellular Carcinoma
Down-Regulation
Therapeutics

Keywords

  • A-443654
  • Akt
  • Antiviral
  • Aurora kinase
  • Hepatitis B virus

ASJC Scopus subject areas

  • Pharmacology
  • Virology

Cite this

Aurora kinase A promotes hepatitis B virus replication and expression. / Jeong, Gi Uk; Ahn, Byung-Yoon.

In: Antiviral Research, Vol. 170, 104572, 01.10.2019.

Research output: Contribution to journalArticle

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