Autoimmunity in microbiome-mediated diseases and novel therapeutic approaches

Cheolmin Shin, Yong Ku Kim

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The microbiome mediates constant bidirectional communication with the host immune system in a delicate balance of inducing pathogenic infection or residing in the human body in a commensal state. Dysbiosis is a hallmark of several autoimmune and immune-mediated inflammatory diseases. Various pathways involved in microbiome-induced autoimmunity are activated when a genetic defect or microbial trigger is found in the inflammasome, neutrophil extracellular trap, or receptors for microbial sensitization in the innate immune system or when similar defects are present in T or B lymphocytes of the adaptive immune system. Regulating autoimmunity through microbiome modulation may be highly effective as a therapeutic intervention.

Original languageEnglish
Pages (from-to)34-42
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume49
DOIs
Publication statusPublished - 2019 Dec 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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