Autoimmunity in microbiome-mediated diseases and novel therapeutic approaches

Cheolmin Shin, Yong Ku Kim

    Research output: Contribution to journalReview articlepeer-review

    9 Citations (Scopus)


    The microbiome mediates constant bidirectional communication with the host immune system in a delicate balance of inducing pathogenic infection or residing in the human body in a commensal state. Dysbiosis is a hallmark of several autoimmune and immune-mediated inflammatory diseases. Various pathways involved in microbiome-induced autoimmunity are activated when a genetic defect or microbial trigger is found in the inflammasome, neutrophil extracellular trap, or receptors for microbial sensitization in the innate immune system or when similar defects are present in T or B lymphocytes of the adaptive immune system. Regulating autoimmunity through microbiome modulation may be highly effective as a therapeutic intervention.

    Original languageEnglish
    Pages (from-to)34-42
    Number of pages9
    JournalCurrent Opinion in Pharmacology
    Publication statusPublished - 2019 Dec

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery


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