Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study

the Korean Multiple Myeloma Working Party (KMMWP)

Research output: Contribution to journalArticle

Abstract

Autologous stem cell transplantation (ASCT) is not frequently performed for elderly patients multiple myeloma (MM) in Korea, despite its being a standardized approach for young patients. Medical records of 150 patients from 15 Korean institutions who received ASCT at age ≥ 64 years were analyzed retrospectively. Patients included had symptomatic MM, and had received their first ASCT at age ≥ 64 following induction chemotherapy. The main outcome was the response after ASCT. Overall survival (OS) and progression-free survival (PFS) were also analyzed. Median time to ASCT was 6.3 months. Complete response plus stringent complete response rate increased from 36 (24.0%) to 105 (70.0%) after ASCT, and high-quality response (≥ very good partial response) increased from 96 (64.0%) to 125 (83.3%). With a median follow-up of 32.6 months after ASCT, 5-year OS and PFS were 59.7% and 22.8%, respectively. Febrile neutropenia occurred in 43.5%, and nausea (21.3%) and stomatitis (13.2%) were common grade 3–4 non-hematologic adverse events. Of 44 deaths, disease progression (n = 23) was the most common cause of mortality, followed by infection (n = 13). Treatment-related death occurred in four cases (2.7%). ASCT is an effective and safe option for elderly MM patients and is associated with superior clinical outcomes.

Original languageEnglish
Pages (from-to)84-95
Number of pages12
JournalInternational Journal of Hematology
Volume112
Issue number1
DOIs
Publication statusPublished - 2020 Jul 1

Keywords

  • Autologous
  • Elderly
  • Multiple myeloma
  • Stem cell
  • Transplantation

ASJC Scopus subject areas

  • Hematology

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