Autolysis: A plausible finding suggestive of long ESD procedure time

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Autolysis is the enzymatic digestion of cells by the action of its own enzymes, and it mostly occurs in dying or dead cells. It has previously been suggested that prolonged procedure time could lead to autolytic changes from the periphery of the endoscopic submucosal dissection specimens. Recently, the authors have experienced a case of autolysis; due to the presence of ulcer, fibrosis, and frequent bleeding from the cut surface, it took 6 hours to complete the resection. More than halfway through the resection; bluish purple discoloration of the part of the dissected flap where the dissection was initiated was noticed. Histologic examination of this site showed diffuse distortion of epithelial lining and cellular architectures along with loss of cell components, compatible with autolysis. Because autolysis could theoretically pose a potential problem regarding the evaluation of resection margin, endoscopists and pathologists should communicate with each other for a reliable pathologic decision.

Original languageEnglish
JournalSurgical Laparoscopy, Endoscopy and Percutaneous Techniques
Volume22
Issue number2
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Autolysis
Cellular Structures
Ulcer
Dissection
Digestion
Fibrosis
Hemorrhage
Enzymes

Keywords

  • autolysis
  • endoscopic submucosal dissection
  • expanded indication

ASJC Scopus subject areas

  • Surgery

Cite this

@article{114f80f8906244bdad716ca860290d60,
title = "Autolysis: A plausible finding suggestive of long ESD procedure time",
abstract = "Autolysis is the enzymatic digestion of cells by the action of its own enzymes, and it mostly occurs in dying or dead cells. It has previously been suggested that prolonged procedure time could lead to autolytic changes from the periphery of the endoscopic submucosal dissection specimens. Recently, the authors have experienced a case of autolysis; due to the presence of ulcer, fibrosis, and frequent bleeding from the cut surface, it took 6 hours to complete the resection. More than halfway through the resection; bluish purple discoloration of the part of the dissected flap where the dissection was initiated was noticed. Histologic examination of this site showed diffuse distortion of epithelial lining and cellular architectures along with loss of cell components, compatible with autolysis. Because autolysis could theoretically pose a potential problem regarding the evaluation of resection margin, endoscopists and pathologists should communicate with each other for a reliable pathologic decision.",
keywords = "autolysis, endoscopic submucosal dissection, expanded indication",
author = "Hyun, {Jong Jin} and Hoon-Jai Chun and Bora Keum and Seo, {Yeon Seok} and Kim, {Yong Sik} and Jeen, {Yoon Tae} and Lee, {Hong Sik} and Soon-Ho Um and Kim, {Chang Duck} and Ryu, {Ho Sang} and Chae, {Yang Seok}",
year = "2012",
month = "4",
day = "1",
doi = "10.1097/SLE.0b013e318247c347",
language = "English",
volume = "22",
journal = "Surgical Laparoscopy, Endoscopy and Percutaneous Techniques",
issn = "1530-4515",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Autolysis

T2 - A plausible finding suggestive of long ESD procedure time

AU - Hyun, Jong Jin

AU - Chun, Hoon-Jai

AU - Keum, Bora

AU - Seo, Yeon Seok

AU - Kim, Yong Sik

AU - Jeen, Yoon Tae

AU - Lee, Hong Sik

AU - Um, Soon-Ho

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

AU - Chae, Yang Seok

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Autolysis is the enzymatic digestion of cells by the action of its own enzymes, and it mostly occurs in dying or dead cells. It has previously been suggested that prolonged procedure time could lead to autolytic changes from the periphery of the endoscopic submucosal dissection specimens. Recently, the authors have experienced a case of autolysis; due to the presence of ulcer, fibrosis, and frequent bleeding from the cut surface, it took 6 hours to complete the resection. More than halfway through the resection; bluish purple discoloration of the part of the dissected flap where the dissection was initiated was noticed. Histologic examination of this site showed diffuse distortion of epithelial lining and cellular architectures along with loss of cell components, compatible with autolysis. Because autolysis could theoretically pose a potential problem regarding the evaluation of resection margin, endoscopists and pathologists should communicate with each other for a reliable pathologic decision.

AB - Autolysis is the enzymatic digestion of cells by the action of its own enzymes, and it mostly occurs in dying or dead cells. It has previously been suggested that prolonged procedure time could lead to autolytic changes from the periphery of the endoscopic submucosal dissection specimens. Recently, the authors have experienced a case of autolysis; due to the presence of ulcer, fibrosis, and frequent bleeding from the cut surface, it took 6 hours to complete the resection. More than halfway through the resection; bluish purple discoloration of the part of the dissected flap where the dissection was initiated was noticed. Histologic examination of this site showed diffuse distortion of epithelial lining and cellular architectures along with loss of cell components, compatible with autolysis. Because autolysis could theoretically pose a potential problem regarding the evaluation of resection margin, endoscopists and pathologists should communicate with each other for a reliable pathologic decision.

KW - autolysis

KW - endoscopic submucosal dissection

KW - expanded indication

UR - http://www.scopus.com/inward/record.url?scp=84859648927&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859648927&partnerID=8YFLogxK

U2 - 10.1097/SLE.0b013e318247c347

DO - 10.1097/SLE.0b013e318247c347

M3 - Article

C2 - 22487637

AN - SCOPUS:84859648927

VL - 22

JO - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques

JF - Surgical Laparoscopy, Endoscopy and Percutaneous Techniques

SN - 1530-4515

IS - 2

ER -