Automated morphometric study of brain variation in XXY males

Dinggang Shen, Dengfeng Liu, Hong Liu, Liv Clasen, Jay Giedd, Christos Davatzikos

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


This paper studies brain morphometry variation associated with XXY males (Klinefelter's syndrome) by using an automated whole-brain volumetric analysis method. The application to 34 XXY males and 62 normal male controls reveals pronounced volume reduction in the brains of XXY males, relative to the brains of normal controls, localized at the insula, temporal gyri, amygdala, hippocampus, cingulate, and occipital gyri. Most of these statistically significant regions are in the gray matter structures, with the exception of one cluster of atrophy involved in white matter structure, i.e., right parietal lobe white matter. Compared to previous findings documented in the literature, our findings provide a better spatial localization of the affected regions. In addition to the reduction of local volume, overall enlargement of ventricles and overall volume reduction of both white matter and gray matter are also found in XXY males.

Original languageEnglish
Pages (from-to)648-653
Number of pages6
Issue number2
Publication statusPublished - 2004 Oct
Externally publishedYes


  • 47,XXY brain
  • Klinefelter's syndrome
  • Morphometric study
  • Sex chromosome aneuploidy
  • Volumetric analysis
  • XXY brain

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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