Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson's Disease

Jin Woo Park, Chan Nyoung Lee, Youngbo Sim, Hyung Kyu Ham, Woo Suk Tae, Byung Jo Kim

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Abstract

Several studies used automated segmentation of hippocampal subfield (ASHS) for detailed measurements of anatomic subregions of the hippocampus, especially in the field of neurodegenerative disorders. In this study, we investigated the hippocampal subfield volume of patients with early-stage nondementia PD compared with normal healthy subjects using the ASHS method. A total of 32 subjects were enrolled in this study (sixteen patients with drug naive nondementia PD and sixteen healthy controls). All subjects were scanned with a 1.5 tesla MRI. The volumes of the seven subfields were calculated separately, and then, the whole hippocampal volume was calculated by the summing of CA1, CA2-3, CA4-DG, subiculum, presubiculum, and fimbria, excluding the hippocampal fissure. There were significant diagnosis-by-hemisphere interactive effects on the total hippocampal volume (F = 5.197; p=0.031) and the subfield volume of CA2-3 (F = 7.586; p=0.010) and CA4-DG (F = 7.403; p=0.011). The volumes of CA2-3 (F = 19.911; p<0.001), CA4-DG (F = 20.273; p<0.001), and total hippocampus (F = 10.573; p=0.005) in the left hemisphere were reduced compared to the right hemisphere. We suggest that the hippocampal volume asymmetry, especially in CA4-DG and CA2-3, could be observed in drug-naïve PD patients even in the early stage of the disease.

Original languageEnglish
Article number8254263
JournalParkinson's Disease
Volume2019
DOIs
Publication statusPublished - 2019 Jan 1

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Parkinson Disease
Hippocampus
Pharmaceutical Preparations
Parahippocampal Gyrus
Neurodegenerative Diseases
Healthy Volunteers

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson's Disease. / Park, Jin Woo; Lee, Chan Nyoung; Sim, Youngbo; Ham, Hyung Kyu; Tae, Woo Suk; Kim, Byung Jo.

In: Parkinson's Disease, Vol. 2019, 8254263, 01.01.2019.

Research output: Contribution to journalArticle

Park, Jin Woo ; Lee, Chan Nyoung ; Sim, Youngbo ; Ham, Hyung Kyu ; Tae, Woo Suk ; Kim, Byung Jo. / Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson's Disease. In: Parkinson's Disease. 2019 ; Vol. 2019.
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