Abstract
Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.
Original language | English |
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Pages (from-to) | 329-336 |
Number of pages | 8 |
Journal | Seminars in Cancer Biology |
Volume | 23 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2013 Oct |
Externally published | Yes |
Keywords
- Autophagy
- Cell death
- Entosis
- Immune
- Macrophage
- Phagocytosis
- Tumor
ASJC Scopus subject areas
- Cancer Research