Autophagy proteins regulate cell engulfment mechanisms that participate in cancer

Sung Eun Kim, Michael Overholtzer

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalSeminars in Cancer Biology
Volume23
Issue number5
DOIs
Publication statusPublished - 2013 Oct
Externally publishedYes

Keywords

  • Autophagy
  • Cell death
  • Entosis
  • Immune
  • Macrophage
  • Phagocytosis
  • Tumor

ASJC Scopus subject areas

  • Cancer Research

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