Avian biomodels for use as pharmaceutical bioreactors and for studying human diseases

Gwonhwa Song, Jae Yong Han

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Animal-based biotechnologies involve the use of domestic animals for the production of pharmaceuticals and various proteins in milk and eggs, as disease models, as tools for stem cell research and animal cloning, and as sources of organs for xenotransplantation into humans. Avian species offer several advantages over mammalian models, and they have been used historically to advance the fields of embryology, immunology, oncology, virology, and vaccine development. In addition, avian species can be used for studying the etiology of human ovarian cancer and other human diseases such as disorders based on the abnormal metabolism of lipids and as unique mechanisms for the biosynthesis and transport of cholesterol. This review integrates recent progress and insight into the molecular and physiologic mechanisms associated with transgenic birds and gives an overview of the use of avian models as pharmaceutical bioreactors and as tools for studying human diseases.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalAnnals of the New York Academy of Sciences
Issue number1
Publication statusPublished - 2011 Jul
Externally publishedYes


  • Avian
  • Biomodel
  • Bioreactor
  • Germ cells
  • Transgenesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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